Oxazolopiperidin-2-ones as Type II‘ β-Turn Mimetics:  Synthesis and Conformational Analysis

2000 ◽  
Vol 65 (21) ◽  
pp. 6992-6999 ◽  
Author(s):  
M. Angels Estiarte ◽  
Mario Rubiralta ◽  
Anna Diez ◽  
Michael Thormann ◽  
Ernest Giralt
Keyword(s):  
Conformational Analysis ◽  
Type Ii

A Bioactive Somatostatin Analog without a Type II? ?-Turn: Synthesis and Conformational Analysis in Solution

2001 ◽  
Vol 7 (10) ◽  
pp. 521-528 ◽  
Author(s):  
Shaokai Jiang ◽  
Sharon Gazal ◽  
Gary Gelerman ◽  
Ofer Ziv ◽  
Olga Karpov ◽  
...  
Keyword(s):  
Conformational Analysis ◽  
Somatostatin Analog ◽  
Type Ii

NMR conformational analysis on cyclic decapeptide template molecule

1999 ◽  
Vol 77 (8) ◽  
pp. 1394-1404 ◽  
Author(s):  
Zhenghong Peng
Keyword(s):  
Conformational Analysis ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Solid Phase Peptide Synthesis ◽  
Template Molecule ◽  
Type Ii ◽  
Proton Nmr Spectroscopy ◽  
Phase Synthesis ◽  
Synthetic Proteins ◽  
Β Sheet

We report the synthesis and conformational analysis of a series of cyclic and bicyclic decapeptide templates for combinatorial chemistry. The peptides were synthesized via solid phase synthesis and followed by solution cyclization. The conformation of the peptides was studied by proton NMR spectroscopy in DMSO and in TFE-water. The structure of the peptide template was calculated with the program DIANA and followed by SA from the NMR experimental constraints. The peptide adopts a fold comprising two β-strands and two type II β-turns. The design of such a restained cyclic decapeptide template will be discussed along with Template Assembled Synthetic Proteins (TASP).Key words: solid phase peptide synthesis, cyclic decapeptide, NMR, conformational analysis, β-sheet.

Preferred Conformations of C-Glycosides. 14. Synthesis and Conformational Analysis of Carbon Analogs of the Blood Group Determinant H-Type II

1995 ◽  
Vol 60 (7) ◽  
pp. 2160-2169 ◽  
Author(s):  
Alexander Wei ◽  
Arnaud Haudrechy ◽  
Catharine Audin ◽  
Hyuk-Sang Jun ◽  
Nathalie Haudrechy-Bretel ◽  
...  
Keyword(s):  
Conformational Analysis ◽  
Blood Group ◽  
Type Ii

scholarly journals Conformational Analysis of the DFG-Out Kinase Motif and Biochemical Profiling of Structurally Validated Type II Inhibitors

2014 ◽  
Vol 58 (1) ◽  
pp. 466-479 ◽  
Author(s):  
R. S. K. Vijayan ◽  
Peng He ◽  
Vivek Modi ◽  
Krisna C. Duong-Ly ◽  
Haiching Ma ◽  
...  
Keyword(s):  
Conformational Analysis ◽  
Type Ii

ChemInform Abstract: Oxazolopiperidin-2-ones as Type II′ β-Turn Mimetics: Synthesis and Conformational Analysis.

ChemInform ◽  
2001 ◽  
Vol 32 (10) ◽  
pp. no-no
Author(s):  
M. Angels Estiarte ◽  
Mario Rubiralta ◽  
Anna Diez ◽  
Michael Thormann ◽  
Ernest Giralt
Keyword(s):  
Conformational Analysis ◽  
Type Ii
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