Silica gel-catalyzed Knoevenagel condensation of peptidyl cyanomethyl ketones with aromatic aldehydes and ketones. A novel Michael acceptor functionality for C-modified peptides: the benzylidene and alkylidene cyanomethyl ketone function

1992 ◽  
Vol 57 (6) ◽  
pp. 1838-1842 ◽  
Author(s):  
Denis Brillon ◽  
Gilles Sauve
Keyword(s):  
Silica Gel ◽  
Knoevenagel Condensation ◽  
Aromatic Aldehydes ◽  
Michael Acceptor ◽  
Aldehydes And Ketones ◽  
Modified Peptides

scholarly journals Environmental-friendly one-pot cascade synthesis of 3-cyanopiperidin-2,6-diones

2019 ◽  
Vol 18 (1) ◽  
pp. 165-170 ◽  
Author(s):  
Daniel Paprocki ◽  
Stanisław Berłożecki ◽  
Ryszard Ostaszewski
Keyword(s):  
Natural Products ◽  
Silica Gel ◽  
Knoevenagel Condensation ◽  
Environmentally Friendly ◽  
Aromatic Aldehydes ◽  
Cyanoacetic Acid ◽  
One Pot ◽  
One Pot Synthesis ◽  
Environmental Friendly ◽  
Wide Range

Abstract 3-Cyanopiperidin-2,6-diones are key intermediates in the synthesis of several drugs and natural products. We developed  one-pot synthesis of 3-cyanopiperidin-2,6-diones by Knoevenagel condensation of cyanoacetic acid and aldehydes, followed by addition of cyanoacetic acid, Achmatowicz reaction and decarboxylation. We tested a wide range of aliphatic and aromatic aldehydes. Products were obtained under simple, environmentally friendly conditions and in yields up to 99%. Substrates were stirred in toluene at reflux, and filtered through short pad of silica gel, and the product was purified by recrystallization.

scholarly journals Reductase for Aromatic Aldehydes and Ketones

1968 ◽  
Vol 243 (4) ◽  
pp. 848-852
Author(s):  
H W Culp ◽  
R E McMahon
Keyword(s):  
Aromatic Aldehydes ◽  
Aldehydes And Ketones

Hydrosilylation of Aromatic Aldehydes and Ketones Catalyzed by Mono- and Tri-Nuclear Platinum(0) Complexes

2018 ◽  
Vol 91 (5) ◽  
pp. 858-864 ◽  
Author(s):  
Yoshitaka Tsuchido ◽  
Ryota Abe ◽  
Megumi Kamono ◽  
Kimiya Tanaka ◽  
Makoto Tanabe ◽  
...  
Keyword(s):  
Aromatic Aldehydes ◽  
Aldehydes And Ketones

Magnesium-Induced Pinacol Coupling of Aromatic Aldehydes and Ketones in Water under Ultrasound.

ChemInform ◽  
2004 ◽  
Vol 35 (17) ◽  
Author(s):  
Ji-Tai Li ◽  
Yan-Jiang Bian ◽  
Shu-Ming Liu ◽  
Tong-Shuang Li
Keyword(s):  
Aromatic Aldehydes ◽  
Pinacol Coupling ◽  
Aldehydes And Ketones

ChemInform Abstract: L-Proline-Catalyzed the Synthesis of Aromatic Aldehydes and Ketones and Their Acridione Derivatives at Room Temperature.

ChemInform ◽  
2016 ◽  
Vol 47 (6) ◽  
pp. no-no
Author(s):  
Fang-Ming Wang ◽  
Dan Bao ◽  
Bing-Xiang Hu ◽  
Ze-Yu Zhou ◽  
Deng-Deng Huang ◽  
...  
Keyword(s):  
Room Temperature ◽  
Aromatic Aldehydes ◽  
Aldehydes And Ketones
Sign in / Sign up

Export Citation Format

Share Document