Fuscosides A-D: anti-inflammatory diterpenoid glycosides of new structural classes from the caribbean gorgonian Eunicea fusca

1991 ◽  
Vol 56 (9) ◽  
pp. 3153-3158 ◽  
Author(s):  
Jongheon Shin ◽  
William Fenical
2011 ◽  
Vol 21 (19) ◽  
pp. 5888-5891 ◽  
Author(s):  
Eduardo Reina ◽  
Carlos Puentes ◽  
Juan Rojas ◽  
Josué García ◽  
Freddy A. Ramos ◽  
...  

2010 ◽  
Vol 63 (6) ◽  
pp. 901 ◽  
Author(s):  
Maysoon B. Saleh ◽  
Russell G. Kerr

Fuscol and the related fuscosides are diterpenes isolated from the Caribbean gorgonian Eunicea fusca, which exhibit potent anti-inflammatory activity with a selective action against leukotriene production in murine models. This report describes the isolation and characterization of the diterpene cyclase product leading to these natural products. The cyclase product has been assigned the trivial name eunicene A and was identified through a radioactivity-guided isolation. Additional biosynthetic experiments conducted by incubating a cell-free extract of E. fusca with 3H-labelled metabolites confirmed the involvement of this unsaturated hydrocarbon in the production of fuscol and fuscosides.


Medicines ◽  
2020 ◽  
Vol 7 (10) ◽  
pp. 59
Author(s):  
Max Samuel Mérida-Reyes ◽  
Manuel Alejandro Muñoz-Wug ◽  
Bessie Evelyn Oliva-Hernández ◽  
Isabel Cristina Gaitán-Fernández ◽  
Daniel Luiz Reis Simas ◽  
...  

Background:Pimenta dioica is a native tree of Central America, Southern Mexico, and the Caribbean used in traditional medicine. It grows in wet forests in the Guatemalan departments of Petén and Izabal. Since the plant is not being economically exploited in Guatemala, this study was aimed at determining the composition of the essential oil of P. dioica leaves and fruits and the antibacterial activity of the leaves in order to evaluate its possible use in health products. The essential oils of fruits and leaves are used as rubefacient, anti-inflammatory, carminative, antioxidant, and antiflatulent in different countries. Methods: Fruits and leaves of P. dioica from Izabal Department were collected in April 2014 and extracted by hydrodistillation method. The oils were analyzed by gas chromatography coupled with mass spectrometry (GC/MS). Results: Yields of 1.02 ± 0.11% for dried leaves and 1.51 ± 0.26% for fruits were obtained. Eugenol was the main component (65.9–71.4%). The leaf oil showed growth inhibition against two Gram-positive and two Gram-negative bacteria. Conclusions: The authors consider that the tree’s leaves can be evaluated as a source of ingredients for antiseptic products, and that it is important to evaluate other types of properties such as anti-inflammatory activity.


2009 ◽  
Vol 17 (21) ◽  
pp. 7542-7547 ◽  
Author(s):  
Valeria Costantino ◽  
Ernesto Fattorusso ◽  
Alfonso Mangoni ◽  
Cristina Perinu ◽  
Giuseppe Cirino ◽  
...  

2012 ◽  
Vol 75 (7) ◽  
pp. 1289-1293 ◽  
Author(s):  
Douglas H. Marchbank ◽  
Fabrice Berrue ◽  
Russell G. Kerr

2000 ◽  
Vol 71 (3) ◽  
pp. 395-400 ◽  
Author(s):  
M.D Garcı́a ◽  
A.M Quı́lez ◽  
M.T Sáenz ◽  
M.E Martı́nez-Domı́nguez ◽  
R de la Puerta

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