Exploring the Structure−Activity Relationships of [1-(4-tert-Butyl-3‘-hydroxy)benzhydryl-4-benzylpiperazine] (SL-3111), A High-Affinity and Selective δ-Opioid Receptor Nonpeptide Agonist Ligand†

Josue Alfaro-Lopez; Toru Okayama; Keiko Hosohata; Peg Davis; Frank Porreca; Henry I. Yamamura; Victor J. Hruby

doi:10.1021/jm990337f

Exploring the Structure−Activity Relationships of [1-(4-tert-Butyl-3‘-hydroxy)benzhydryl-4-benzylpiperazine] (SL-3111), A High-Affinity and Selective δ-Opioid Receptor Nonpeptide Agonist Ligand†

Journal of Medicinal Chemistry ◽

10.1021/jm990337f ◽

1999 ◽

Vol 42 (26) ◽

pp. 5359-5368 ◽

Cited By ~ 19

Author(s):

Josue Alfaro-Lopez ◽

Toru Okayama ◽

Keiko Hosohata ◽

Peg Davis ◽

Frank Porreca ◽

...

Keyword(s):

Opioid Receptor ◽

Tert Butyl ◽

Structure Activity Relationships ◽

High Affinity ◽

Structure Activity ◽

Δ Opioid Receptor

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3D Quantitative and Qualitative Structure-Activity Relationships of the δ -Opioid Receptor Antagonists

Bulletin of the Korean Chemical Society ◽

10.5012/bkcs.2008.29.3.656 ◽

2008 ◽

Vol 29 (3) ◽

pp. 656-662 ◽

Cited By ~ 2

Keyword(s):

Opioid Receptor ◽

Receptor Antagonists ◽

Structure Activity Relationships ◽

Structure Activity ◽

Opioid Receptor Antagonists ◽

Qualitative Structure ◽

Δ Opioid Receptor

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Structure-activity relationships for insect growth regulators derived from substituted di-tert-butyl phenols

Pesticide Biochemistry and Physiology ◽

10.1016/0048-3575(79)90090-7 ◽

1979 ◽

Vol 12 (1) ◽

pp. 23-30 ◽

Cited By ~ 7

Author(s):

Barbara T. Walton ◽

James R. Sanborn ◽

Robert L. Metcalf

Keyword(s):

Growth Regulators ◽

Insect Growth Regulators ◽

Insect Growth ◽

Tert Butyl ◽

Structure Activity Relationships ◽

Structure Activity

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The fine tuning of high affinity and selective non-peptide agonists of the δ-opioid receptor via solution and solid-phase

Peptides for the New Millennium - American Peptide Symposia ◽

10.1007/0-306-46881-6_12 ◽

2006 ◽

pp. 38-39

Author(s):

Josue Alfaro-Lopez ◽

Toru Okayama ◽

Keiko Hosohata ◽

Peg Davis ◽

Frank Porreca ◽

...

Keyword(s):

Opioid Receptor ◽

Solid Phase ◽

Fine Tuning ◽

High Affinity ◽

Δ Opioid Receptor

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Synthesis and Structure–Activity Relationships of 5′-Aryl-14-alkoxypyridomorphinans: Identification of a μ Opioid Receptor Agonist/δ Opioid Receptor Antagonist Ligand with Systemic Antinociceptive Activity and Diminished Opioid Side Effects

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.0c00503 ◽

2020 ◽

Vol 63 (14) ◽

pp. 7663-7694 ◽

Cited By ~ 2

Author(s):

Rakesh H. Vekariya ◽

Wei Lei ◽

Abhisek Ray ◽

Surendra K. Saini ◽

Sixue Zhang ◽

...

Keyword(s):

Side Effects ◽

Receptor Antagonist ◽

Opioid Receptor ◽

Receptor Agonist ◽

Antinociceptive Activity ◽

Opioid Receptor Antagonist ◽

Structure Activity ◽

Opioid Receptor Agonist ◽

Μ Opioid Receptor ◽

Δ Opioid Receptor

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Redefining the structure–activity relationships of 2,6-methano-3-benzazocines. Part 6: Opioid receptor binding properties of cyclic variants of 8-carboxamidocyclazocine

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2008.03.066 ◽

2008 ◽

Vol 16 (10) ◽

pp. 5653-5664 ◽

Cited By ~ 5

Author(s):

Mark P. Wentland ◽

Xufeng Sun ◽

Dana J. Cohen ◽

Jean M. Bidlack

Keyword(s):

Opioid Receptor ◽

Receptor Binding ◽

Binding Properties ◽

Structure Activity Relationships ◽

Structure Activity ◽

Opioid Receptor Binding Properties ◽

Opioid Receptor Binding

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Structure-Activity Relationships of Nociceptin Receptor (NOP) Ligands and the Design of Bifunctional NOP/Mu Opioid Receptor-Targeted Ligands

ACS Symposium Series - Research and Development of Opioid-Related Ligands ◽

10.1021/bk-2013-1131.ch008 ◽

2013 ◽

pp. 145-160 ◽

Cited By ~ 4

Author(s):

Nurulain T. Zaveri ◽

Dennis Yasuda ◽

Blair V. Journigan ◽

Pankaj R. Daga ◽

Faming Jiang ◽

...

Keyword(s):

Opioid Receptor ◽

Mu Opioid Receptor ◽

Mu Opioid ◽

Structure Activity Relationships ◽

Structure Activity ◽

Nociceptin Receptor

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Redefining the structure–activity relationships of 2,6-methano-3-benzazocines. 5. Opioid receptor binding properties of N-((4′-phenyl)-phenethyl) analogues of 8-CAC

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2007.09.082 ◽

2007 ◽

Vol 17 (23) ◽

pp. 6516-6520 ◽

Cited By ~ 9

Author(s):

Melissa A. VanAlstine ◽

Mark P. Wentland ◽

Dana J. Cohen ◽

Jean M. Bidlack

Keyword(s):

Opioid Receptor ◽

Receptor Binding ◽

Binding Properties ◽

Structure Activity Relationships ◽

Structure Activity ◽

Opioid Receptor Binding Properties ◽

Opioid Receptor Binding

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2-Aryl-5-tert-butyl-1,3-dithianes and their S-oxidation products: structure-activity relationships of potent insecticides acting at the GABA-gated chloride channel

Journal of Agricultural and Food Chemistry ◽

10.1021/jf00015a028 ◽

1992 ◽

Vol 40 (3) ◽

pp. 497-505 ◽

Cited By ~ 22

Author(s):

Vincent J. Wacher ◽

Robert F. Toia ◽

John E. Casida

Keyword(s):

Chloride Channel ◽

Oxidation Products ◽

Tert Butyl ◽

Structure Activity Relationships ◽

Structure Activity ◽

S Oxidation

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AR-A000002, a high affinity 5-HT1B receptor antagonist: Synthesis and structure-activity relationships

European Neuropsychopharmacology ◽

10.1016/s0924-977x(01)80198-x ◽

2001 ◽

Vol 11 ◽

pp. S213-S214

Author(s):

S. Berg ◽

S. Hellberg ◽

M. Linderberg ◽

M. Nylöf ◽

G. Nordvall

Keyword(s):

Receptor Antagonist ◽

Structure Activity Relationships ◽

High Affinity ◽

Structure Activity

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ChemInform Abstract: De Novo Design, Synthesis, and Biological Activities of High-Affinity and Selective Non-Peptide Agonists of the δ-Opioid Receptor.

ChemInform ◽

10.1002/chin.199913184 ◽

2010 ◽

Vol 30 (13) ◽

pp. no-no

Author(s):

Victor J. Hruby ◽

ET AL. ET AL.

Keyword(s):

Opioid Receptor ◽

De Novo ◽

Biological Activities ◽

De Novo Design ◽

Design Synthesis ◽

High Affinity ◽

Δ Opioid Receptor

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