2‘,6‘-Dimethylphenoxyacetyl:  A New Achiral High Affinity P3-P2Ligand for Peptidomimetic-Based HIV Protease Inhibitors

Pierre L. Beaulieu; Paul C. Anderson; Dale R. Cameron; Gilbert Croteau; Vida Gorys; Chantal Grand-Maître; Daniel Lamarre; Francine Liard; William Paris; Louis Plamondon; François Soucy; Diane Thibeault; Dominik Wernic; Christiane Yoakim; Susan Pav; Liang Tong

doi:10.1021/jm990336n

2‘,6‘-Dimethylphenoxyacetyl: A New Achiral High Affinity P3-P2Ligand for Peptidomimetic-Based HIV Protease Inhibitors

Journal of Medicinal Chemistry ◽

10.1021/jm990336n ◽

2000 ◽

Vol 43 (6) ◽

pp. 1094-1108 ◽

Cited By ~ 22

Author(s):

Pierre L. Beaulieu ◽

Paul C. Anderson ◽

Dale R. Cameron ◽

Gilbert Croteau ◽

Vida Gorys ◽

...

Keyword(s):

Protease Inhibitors ◽

Hiv Protease ◽

Hiv Protease Inhibitors ◽

High Affinity

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Chiral Auxiliary Mediated Conjugate Reduction and Asymmetric Protonation: Synthesis of High Affinity Ligands for HIV Protease Inhibitors

The Journal of Organic Chemistry ◽

10.1021/jo00124a042 ◽

1995 ◽

Vol 60 (19) ◽

pp. 6198-6201 ◽

Cited By ~ 10

Author(s):

Arun K. Ghosh ◽

Wenming Liu

Keyword(s):

Protease Inhibitors ◽

Chiral Auxiliary ◽

Hiv Protease ◽

Hiv Protease Inhibitors ◽

Affinity Ligands ◽

High Affinity ◽

Conjugate Reduction

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ChemInform Abstract: 2′,6′-Dimethylphenoxyacetyl: A New Achiral High Affinity P3-P2 Ligand for Peptidomimetic-Based HIV Protease Inhibitors.

ChemInform ◽

10.1002/chin.200030180 ◽

2010 ◽

Vol 31 (30) ◽

pp. no-no

Author(s):

Pierre L. Beaulieu ◽

et al. et al.

Keyword(s):

Protease Inhibitors ◽

Hiv Protease ◽

Hiv Protease Inhibitors ◽

High Affinity

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HIV Protease Inhibitors Possessing a Novel, High-Affinity, and Achiral P1'/P2' Ligand with a Unique Pattern of in Vitro Resistance. Importance of a Conformationally-Restricted Template in the Design of Enzyme Inhibitors

Journal of the American Chemical Society ◽

10.1021/ja00150a005 ◽

1995 ◽

Vol 117 (45) ◽

pp. 11070-11074 ◽

Cited By ~ 26

Author(s):

J. V. N. Vara Prasad ◽

Elizabeth A. Lunney ◽

Donna Ferguson ◽

Peter J. Tummino ◽

J. Ronald Rubin ◽

...

Keyword(s):

Protease Inhibitors ◽

Enzyme Inhibitors ◽

Hiv Protease ◽

Hiv Protease Inhibitors ◽

Unique Pattern ◽

Conformationally Restricted ◽

High Affinity

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Potent HIV protease inhibitors incorporating high-affinity P2-ligands and (R)-(hydroxyethylamino)sulfonamide isostere

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/s0960-894x(98)00098-5 ◽

1998 ◽

Vol 8 (6) ◽

pp. 687-690 ◽

Cited By ~ 109

Author(s):

Arun K Ghosh ◽

John F Kincaid ◽

Wonhwa Cho ◽

D.Eric Walters ◽

K Krishnan ◽

...

Keyword(s):

Protease Inhibitors ◽

Hiv Protease ◽

Hiv Protease Inhibitors ◽

High Affinity

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ChemInform Abstract: Chiral Auxiliary Mediated Conjugate Reduction and Asymmetric Protonation: Synthesis of High Affinity Ligands for HIV Protease Inhibitors.

ChemInform ◽

10.1002/chin.199606164 ◽

2010 ◽

Vol 27 (6) ◽

pp. no-no

Author(s):

A. K. GHOSH ◽

W. LIU

Keyword(s):

Protease Inhibitors ◽

Chiral Auxiliary ◽

Hiv Protease ◽

Hiv Protease Inhibitors ◽

Affinity Ligands ◽

High Affinity ◽

Conjugate Reduction

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ChemInform Abstract: Potent HIV Protease Inhibitors Incorporating High-Affinity P2-Ligands and (R)-(Hydroxyethylamino)sulfonamide Isostere.

ChemInform ◽

10.1002/chin.199827122 ◽

2010 ◽

Vol 29 (27) ◽

pp. no-no

Author(s):

A. K. GHOSH ◽

ET AL. ET AL.

Keyword(s):

Protease Inhibitors ◽

Hiv Protease ◽

Hiv Protease Inhibitors ◽

High Affinity

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Determining and Overcoming Resistance to HIV Protease Inhibitors

Current Drug Targets - Infectious Disorders ◽

10.2174/1568005043340984 ◽

2004 ◽

Vol 4 (2) ◽

pp. 137-152 ◽

Cited By ~ 17

Author(s):

Jana Prejdova ◽

Milan Soucek ◽

Jan Konvalinka

Keyword(s):

Protease Inhibitors ◽

Hiv Protease ◽

Hiv Protease Inhibitors

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A QSAR Study of HIV Protease Inhibitors Using Theoretical Descriptors

Current Computer - Aided Drug Design ◽

10.2174/1573409911006040269 ◽

2010 ◽

Vol 6 (4) ◽

pp. 269-282 ◽

Cited By ~ 4

Author(s):

Subhash C. Basak ◽

Denise Mills ◽

Rajni Garg ◽

Barun Bhhatarai

Keyword(s):

Protease Inhibitors ◽

Hiv Protease ◽

Hiv Protease Inhibitors ◽

Qsar Study

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Simultaneous determination of the HIV protease inhibitors indinavir, amprenavir, saquinavir, ritonavir and nelfinavir in human plasma by high-performance liquid chromatography

Journal of Chromatography B Biomedical Sciences and Applications ◽

10.1016/s0378-4347(00)00617-4 ◽

2001 ◽

Vol 755 (1-2) ◽

pp. 85-89 ◽

Cited By ~ 32

Author(s):

Harumi Yamada ◽

Hajime Kotaki ◽

Tetsuya Nakamura ◽

Aikichi Iwamoto

Keyword(s):

High Performance Liquid Chromatography ◽

Liquid Chromatography ◽

Simultaneous Determination ◽

Human Plasma ◽

Protease Inhibitors ◽

High Performance ◽

Hiv Protease ◽

Hiv Protease Inhibitors

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1351 SYNERGISTIC EFFECTS OF ALCOHOL AND HIV PROTEASE INHIBITORS ON CALCIUM HOMEOSTASIS, STRESS RESPONSE AND INJURY IN MOUSE AND HUMAN HEPATOCYTES

Journal of Hepatology ◽

10.1016/s0168-8278(12)61362-2 ◽

2012 ◽

Vol 56 ◽

pp. S531

Author(s):

C. Ji

Keyword(s):

Stress Response ◽

Protease Inhibitors ◽

Calcium Homeostasis ◽

Synergistic Effects ◽

Human Hepatocytes ◽

Hiv Protease ◽

Hiv Protease Inhibitors

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