Structure-Based Design, Synthesis, and Biological Evaluation of Novel Pyrrolyl Aryl Sulfones:  HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors Active at Nanomolar Concentrations

Marino Artico; Romano Silvestri; Eugenia Pagnozzi; Biancamaria Bruno; Ettore Novellino; Giovanni Greco; Silvio Massa; Alessandro Ettorre; Anna Giulia Loi; Franca Scintu; Paolo La Colla

doi:10.1021/jm9901125

Structure-Based Design, Synthesis, and Biological Evaluation of Novel Pyrrolyl Aryl Sulfones: HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors Active at Nanomolar Concentrations

Journal of Medicinal Chemistry ◽

10.1021/jm9901125 ◽

2000 ◽

Vol 43 (9) ◽

pp. 1886-1891 ◽

Cited By ~ 80

Author(s):

Marino Artico ◽

Romano Silvestri ◽

Eugenia Pagnozzi ◽

Biancamaria Bruno ◽

Ettore Novellino ◽

...

Keyword(s):

Reverse Transcriptase ◽

Biological Evaluation ◽

Reverse Transcriptase Inhibitors ◽

Nucleoside Reverse Transcriptase Inhibitors ◽

Design Synthesis ◽

Synthesis And Biological Evaluation ◽

Hiv 1

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Design, synthesis, and biological evaluation of novel 5-Alkyl-6-Adamantylmethylpyrimidin-4(3H)-ones as HIV-1 non-nucleoside reverse-transcriptase inhibitors

Chemical Biology & Drug Design ◽

10.1111/cbdd.12765 ◽

2016 ◽

Vol 88 (3) ◽

pp. 380-385 ◽

Cited By ~ 2

Author(s):

Wenxin Li ◽

Boshi Huang ◽

Dongwei Kang ◽

Erik De Clercq ◽

Dirk Daelemans ◽

...

Keyword(s):

Reverse Transcriptase ◽

Biological Evaluation ◽

Reverse Transcriptase Inhibitors ◽

Nucleoside Reverse Transcriptase Inhibitors ◽

Design Synthesis ◽

Synthesis And Biological Evaluation ◽

Hiv 1

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Design, Synthesis, and Biological Evaluation of 1-[(2-Benzyloxyl/alkoxyl)methyl]-5-halo-6-aryluracils as Potent HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors with an Improved Drug Resistance Profile

Journal of Medicinal Chemistry ◽

10.1021/jm201506e ◽

2012 ◽

Vol 55 (5) ◽

pp. 2242-2250 ◽

Cited By ~ 26

Author(s):

Xiaowei Wang ◽

Jianfang Zhang ◽

Yang Huang ◽

Ruiping Wang ◽

Liang Zhang ◽

...

Keyword(s):

Drug Resistance ◽

Reverse Transcriptase ◽

Biological Evaluation ◽

Reverse Transcriptase Inhibitors ◽

Nucleoside Reverse Transcriptase Inhibitors ◽

Design Synthesis ◽

Resistance Profile ◽

Drug Resistance Profile ◽

Synthesis And Biological Evaluation ◽

Hiv 1

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ChemInform Abstract: Structure-Based Design, Synthesis, and Biological Evaluation of Novel Pyrrolyl Aryl Sulfones (I): HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors Active at Nanomolar Concentrations.

ChemInform ◽

10.1002/chin.200030099 ◽

2010 ◽

Vol 31 (30) ◽

pp. no-no

Author(s):

Marino Artico ◽

et al. et al.

Keyword(s):

Reverse Transcriptase ◽

Biological Evaluation ◽

Reverse Transcriptase Inhibitors ◽

Nucleoside Reverse Transcriptase Inhibitors ◽

Design Synthesis ◽

Abstract Structure ◽

Synthesis And Biological Evaluation ◽

Hiv 1

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Arylazolylthioacetanilide. Part 11: Design, Synthesis and Biological Evaluation of 1,2,4-triazole Thioacetanilide Derivatives as Novel Non-nucleoside HIV-1 Reverse Transcriptase Inhibitors

Medicinal Chemistry ◽

10.2174/1573406411309070010 ◽

2013 ◽

Vol 9 (7) ◽

pp. 968-973 ◽

Cited By ~ 9

Author(s):

Zhenyu Li ◽

Yuan Cao ◽

Peng Zhan ◽

Christophe Pannecouque ◽

Jan Balzarini ◽

...

Keyword(s):

Reverse Transcriptase ◽

Biological Evaluation ◽

Reverse Transcriptase Inhibitors ◽

Design Synthesis ◽

Synthesis And Biological Evaluation ◽

Hiv 1

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Design, Synthesis, and Biological Evaluation of Novel 2H-Pyran-2-one Derivatives as Potential HIV-1 Reverse Transcriptase Inhibitors

Archiv der Pharmazie ◽

10.1002/ardp.201400235 ◽

2014 ◽

Vol 348 (1) ◽

pp. 23-33 ◽

Cited By ~ 11

Author(s):

Andrea Defant ◽

Ines Mancini ◽

Rossella Tomazzolli ◽

Jan Balzarini

Keyword(s):

Reverse Transcriptase ◽

Biological Evaluation ◽

Reverse Transcriptase Inhibitors ◽

Design Synthesis ◽

Synthesis And Biological Evaluation ◽

Hiv 1

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Synthesis and Biological Evaluation of Alkenyldiarylmethane HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors That Possess Increased Hydrolytic Stability

Journal of Medicinal Chemistry ◽

10.1021/jm070382k ◽

2007 ◽

Vol 50 (20) ◽

pp. 4854-4867 ◽

Cited By ~ 17

Author(s):

Matthew D. Cullen ◽

Bo-Liang Deng ◽

Tracy L. Hartman ◽

Karen M. Watson ◽

Robert W. Buckheit, ◽

...

Keyword(s):

Reverse Transcriptase ◽

Hydrolytic Stability ◽

Biological Evaluation ◽

Reverse Transcriptase Inhibitors ◽

Nucleoside Reverse Transcriptase Inhibitors ◽

Synthesis And Biological Evaluation ◽

Hiv 1

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Design, discovery, modelling, synthesis, and biological evaluation of novel and small, low toxicity s-triazine derivatives as HIV-1 non-nucleoside reverse transcriptase inhibitors

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2016.04.018 ◽

2016 ◽

Vol 24 (11) ◽

pp. 2519-2529 ◽

Cited By ~ 13

Author(s):

Birgit Viira ◽

Anastasia Selyutina ◽

Alfonso T. García-Sosa ◽

Maarit Karonen ◽

Jari Sinkkonen ◽

...

Keyword(s):

Reverse Transcriptase ◽

Biological Evaluation ◽

Reverse Transcriptase Inhibitors ◽

Nucleoside Reverse Transcriptase Inhibitors ◽

Triazine Derivatives ◽

Low Toxicity ◽

Synthesis And Biological Evaluation ◽

Hiv 1

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Newer aminopyrimidinimino isatin analogues as non-nucleoside HIV-1 reverse transcriptase inhibitors for HIV and other opportunistic infections of AIDS: design, synthesis and biological evaluation

Il Farmaco ◽

10.1016/j.farmac.2005.03.005 ◽

2005 ◽

Vol 60 (5) ◽

pp. 377-384 ◽

Cited By ~ 27

Author(s):

D. Sriram ◽

T.R. Bal ◽

P. Yogeeswari

Keyword(s):

Reverse Transcriptase ◽

Opportunistic Infections ◽

Biological Evaluation ◽

Reverse Transcriptase Inhibitors ◽

Design Synthesis ◽

Synthesis And Biological Evaluation ◽

Hiv 1

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Synthesis and biological evaluation of novel 1-aryl-5-iodo-6-benzyluracils as potent HIV-1 non-nucleoside reverse transcriptase inhibitors

Journal of Chinese Pharmaceutical Sciences ◽

10.5246/jcps.2010.04.044 ◽

2010 ◽

Vol 19 (4) ◽

Author(s):

Wei Wang ◽

Jun-Yi Liu

Keyword(s):

Reverse Transcriptase ◽

Biological Evaluation ◽

Reverse Transcriptase Inhibitors ◽

Nucleoside Reverse Transcriptase Inhibitors ◽

Synthesis And Biological Evaluation ◽

Hiv 1

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ChemInform Abstract: Synthesis and Biological Evaluation of Certain Alkenyldiarylmethanes as Anti-HIV-1 Agents Which Act as Non-Nucleoside Reverse Transcriptase Inhibitors.

ChemInform ◽

10.1002/chin.199648103 ◽

2010 ◽

Vol 27 (48) ◽

pp. no-no

Author(s):

M. CUSHMAN ◽

W. M. GOLEBIEWSKI ◽

L. GRAHAM ◽

J. A. TURPIN ◽

W. G. RICE ◽

...

Keyword(s):

Reverse Transcriptase ◽

Biological Evaluation ◽

Reverse Transcriptase Inhibitors ◽

Nucleoside Reverse Transcriptase Inhibitors ◽

Synthesis And Biological Evaluation ◽

Anti Hiv ◽

Hiv 1

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