Benzodiazepine Receptor Ligands. 4. Synthesis and Pharmacological Evaluation of 3-Heteroaryl-8-chloropyrazolo[5,1-c][1,2,4]benzotriazine 5-Oxides

Annarella Costanzo; Gabriella Guerrini; Giovanna Ciciani; Fabrizio Bruni; Silvia Selleri; Barbara Costa; Claudia Martini; Antonio Lucacchini; Petra Malmberg Aiello; Alessandra Ipponi

doi:10.1021/jm981126y

Benzodiazepine Receptor Ligands. 4. Synthesis and Pharmacological Evaluation of 3-Heteroaryl-8-chloropyrazolo[5,1-c][1,2,4]benzotriazine 5-Oxides

Journal of Medicinal Chemistry ◽

10.1021/jm981126y ◽

1999 ◽

Vol 42 (12) ◽

pp. 2218-2226 ◽

Cited By ~ 27

Author(s):

Annarella Costanzo ◽

Gabriella Guerrini ◽

Giovanna Ciciani ◽

Fabrizio Bruni ◽

Silvia Selleri ◽

...

Keyword(s):

Benzodiazepine Receptor ◽

Receptor Ligands ◽

Benzodiazepine Receptor Ligands ◽

Pharmacological Evaluation

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Benzodiazepine receptor ligands. 8: Synthesis and pharmacological evaluation of new pyrazolo[5,1-c] [1,2,4]benzotriazine 5-oxide 3- and 8-disubstituted: High affinity ligands endowed with inverse-agonist pharmacological efficacy

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2005.08.058 ◽

2006 ◽

Vol 14 (3) ◽

pp. 758-775 ◽

Cited By ~ 24

Author(s):

Gabriella Guerrini ◽

Annarella Costanzo ◽

Giovanna Ciciani ◽

Fabrizio Bruni ◽

Silvia Selleri ◽

...

Keyword(s):

Benzodiazepine Receptor ◽

Inverse Agonist ◽

Receptor Ligands ◽

Affinity Ligands ◽

Benzodiazepine Receptor Ligands ◽

High Affinity ◽

Pharmacological Evaluation

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ChemInform Abstract: Benzodiazepine Receptor Ligands. Synthesis and Preliminary Pharmacological Evaluation of Some 3,7-Disubstituted-4H-(1,2,4)Triazino(3,4-a)phthalazines and 3,7-Disubstituted-4H-(1,2,4)Triazino(3,4-a)phthalazin-4-ones.

ChemInform ◽

10.1002/chin.198938259 ◽

1989 ◽

Vol 20 (38) ◽

Author(s):

E. OCCELLI ◽

G. TARZIA ◽

D. BARONE

Keyword(s):

Benzodiazepine Receptor ◽

Receptor Ligands ◽

Benzodiazepine Receptor Ligands ◽

Pharmacological Evaluation

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Benzodiazepine receptor ligands. Synthesis and pharmacological evaluation of 3-, 7- and 8-substituted [5,1-c][1,2,4]benzotriazines and 5-oxide derivatives. Part I

European Journal of Medicinal Chemistry ◽

10.1016/0223-5234(96)80363-1 ◽

1996 ◽

Vol 31 (4) ◽

pp. 259-272 ◽

Cited By ~ 14

Author(s):

G Guerrini ◽

A Costanzo ◽

F Bruni ◽

S Selleri ◽

L Casilli ◽

...

Keyword(s):

Benzodiazepine Receptor ◽

Receptor Ligands ◽

Benzodiazepine Receptor Ligands ◽

Pharmacological Evaluation

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Benzodiazepine Receptor Ligands. 7. Synthesis and Pharmacological Evaluation of New 3-Esters of the 8-Chloropyrazolo[5,1-c][1,2,4]benzotriazine 5-oxide. 3-(2-Thienylmethoxycarbonyl) Derivative: An Anxioselective Agent in Rodents

Journal of Medicinal Chemistry ◽

10.1021/jm020944u ◽

2002 ◽

Vol 45 (26) ◽

pp. 5710-5720 ◽

Cited By ~ 16

Author(s):

Annarella Costanzo ◽

Gabriella Guerrini ◽

Giovanna Ciciani ◽

Fabrizio Bruni ◽

Camilla Costagli ◽

...

Keyword(s):

Benzodiazepine Receptor ◽

Receptor Ligands ◽

Benzodiazepine Receptor Ligands ◽

Pharmacological Evaluation

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ChemInform Abstract: Benzodiazepine Receptor Ligands. Synthesis and Pharmacological Evaluation of 6-Aryl-3,8-disubstituted-1,2,4-triazolo(3,4-a)phthalazines.

ChemInform ◽

10.1002/chin.198923193 ◽

1989 ◽

Vol 20 (23) ◽

Author(s):

G. TARZIA ◽

E. OCCELLI ◽

D. BARONE

Keyword(s):

Benzodiazepine Receptor ◽

Receptor Ligands ◽

Benzodiazepine Receptor Ligands ◽

Pharmacological Evaluation

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ChemInform Abstract: Benzodiazepine Receptor Ligands. Synthesis and Preliminary Pharmacological Evaluation of 2-Aminoalkyl-8-chloro- and 2-Aryl-1,2,4-triazolo-(3,4-a)phthalazin-3(2H)-ones.

ChemInform ◽

10.1002/chin.198938248 ◽

1989 ◽

Vol 20 (38) ◽

Author(s):

G. TARZIA ◽

E. OCCELLI ◽

N. CORSICO ◽

L. GALLICO ◽

F. LUZZANI ◽

...

Keyword(s):

Benzodiazepine Receptor ◽

Receptor Ligands ◽

Benzodiazepine Receptor Ligands ◽

Pharmacological Evaluation

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Peripheral benzodiazepine receptor ligands induce apoptosis and cell cycle arrest in human hepatocellular carcinoma cells and enhance chemosensitivity to paclitaxel, docetaxel, doxorubicin and the Bcl–2 inhibitor HA14–1

Zeitschrift für Gastroenterologie ◽

10.1055/s-2004-831695 ◽

2004 ◽

Vol 42 (08) ◽

Author(s):

A Sutter ◽

K Maaser ◽

P Grabowski ◽

M Höpfner ◽

A Krahn ◽

...

Keyword(s):

Hepatocellular Carcinoma ◽

Cell Cycle ◽

Cell Cycle Arrest ◽

Benzodiazepine Receptor ◽

Carcinoma Cells ◽

Peripheral Benzodiazepine Receptor ◽

Receptor Ligands ◽

Benzodiazepine Receptor Ligands ◽

Cycle Arrest ◽

Human Hepatocellular Carcinoma Cells

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Benzodiazepine Receptor Ligands, Memory and Information Processing

10.1007/978-3-642-73288-1 ◽

1988 ◽

Cited By ~ 5

Keyword(s):

Information Processing ◽

Benzodiazepine Receptor ◽

Receptor Ligands ◽

Benzodiazepine Receptor Ligands

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Benzodiazepine receptor ligands and sexual behavior in the male rat: The role of GABAergic mechanisms

Pharmacology Biochemistry and Behavior ◽

10.1016/0091-3057(91)90242-t ◽

1991 ◽

Vol 38 (4) ◽

pp. 781-788 ◽

Cited By ~ 10

Author(s):

Anders Ågmo ◽

Hilda Fernández

Keyword(s):

Sexual Behavior ◽

Benzodiazepine Receptor ◽

Male Rat ◽

Receptor Ligands ◽

Benzodiazepine Receptor Ligands

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Specific high-affinity binding of peripheral benzodiazepine receptor ligands to brain tumors in rat and man

Cancer ◽

10.1002/1097-0142(19900101)65:1<93::aid-cncr2820650120>3.0.co;2-1 ◽

1990 ◽

Vol 65 (1) ◽

pp. 93-97 ◽

Cited By ~ 45

Author(s):

Keith L. Black ◽

Kiyonobu Ikezaki ◽

Emily Santori ◽

Donald P. Becker ◽

Harry V. Vinters

Keyword(s):

Brain Tumors ◽

Benzodiazepine Receptor ◽

Affinity Binding ◽

Peripheral Benzodiazepine Receptor ◽

Receptor Ligands ◽

High Affinity Binding ◽

Benzodiazepine Receptor Ligands ◽

High Affinity

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