Synthesis and Characterization of Fluorescent Ligands for the Norepinephrine Transporter:  Potential Neuroblastoma Imaging Agents

1999 ◽  
Vol 42 (16) ◽  
pp. 3101-3108 ◽  
Author(s):  
Dirk Hadrich ◽  
Frank Berthold ◽  
Eberhard Steckhan ◽  
Heinz Bönisch
Keyword(s):  
Norepinephrine Transporter ◽  
Synthesis And Characterization ◽  
Imaging Agents ◽  
Fluorescent Ligands

Synthesis and characterization of neutral oxotechnetium(V) bisaminoethanethiol complexes: potential brain imaging agents

Polyhedron ◽  
1992 ◽  
Vol 11 (10) ◽  
pp. 1145-1155 ◽  
Author(s):  
Christy S. John ◽  
Lynn C. Francesconi ◽  
Hank F. Kung ◽  
Suzanne Wehrli ◽  
Grazyna Graczyk ◽  
...  
Keyword(s):  
Brain Imaging ◽  
Synthesis And Characterization ◽  
Imaging Agents

Synthesis and Characterization of Selective Fluorescent Ligands for the neurokinin NK2 Receptor

1994 ◽  
Vol 37 (13) ◽  
pp. 1991-1995 ◽  
Author(s):  
Charles G. Bradshaw ◽  
Karin Ceszkowski ◽  
Gerardo Turcatti ◽  
Isabel J. M. Beresford ◽  
Andre Chollet
Keyword(s):  
Synthesis And Characterization ◽  
Fluorescent Ligands ◽  
Nk2 Receptor

scholarly journals Synthesis and Characterization of High-Affinity 4,4-Difluoro-4-bora-3a,4a-diaza-s-indacene-Labeled Fluorescent Ligands for Human β-Adrenoceptors

2011 ◽  
Vol 54 (19) ◽  
pp. 6874-6887 ◽  
Author(s):  
Jillian G. Baker ◽  
Luke A. Adams ◽  
Karolina Salchow ◽  
Shailesh N. Mistry ◽  
Richard J. Middleton ◽  
...  
Keyword(s):  
Synthesis And Characterization ◽  
High Affinity ◽  
Fluorescent Ligands

Synthesis and Characterization of Technetium-99m-Labeled Tropanes as Dopamine Transporter-Imaging Agents

1997 ◽  
Vol 40 (1) ◽  
pp. 9-17 ◽  
Author(s):  
Sanath K. Meegalla ◽  
Karl Plössl ◽  
Mei-Ping Kung ◽  
Sumalee Chumpradit ◽  
D. Andrew Stevenson ◽  
...  
Keyword(s):  
Dopamine Transporter ◽  
Synthesis And Characterization ◽  
Imaging Agents ◽  
Dopamine Transporter Imaging ◽  
Technetium 99M

Synthesis and characterization of iodobenzamide analogs: potential D-2 dopamine receptor imaging agents

1990 ◽  
Vol 33 (1) ◽  
pp. 171-178 ◽  
Author(s):  
Raymond A. Murphy ◽  
Hank F. Kung ◽  
Mei Ping Kung ◽  
Jeffrey Billings
Keyword(s):  
Dopamine Receptor ◽  
Synthesis And Characterization ◽  
Imaging Agents ◽  
Receptor Imaging

scholarly journals Environment-Sensitive Fluorescence of 7-Nitrobenz-2-oxa-1,3-Diazol-4-yl (NBD)-Labeled Ligands for Serotonin Receptors

Molecules ◽  
2021 ◽  
Vol 26 (13) ◽  
pp. 3848
Author(s):  
Parijat Sarkar ◽  
Kaleeckal G. Harikumar ◽  
Satinder S. Rawat ◽  
Sanjib Das ◽  
Tushar K. Chakraborty ◽  
...  
Keyword(s):  
Cell Surface ◽  
Serotonin Receptors ◽  
Multiple Roles ◽  
Synthesis And Characterization ◽  
Future Studies ◽  
Serotonin1a Receptor ◽  
Red Edge ◽  
Red Edge Excitation Shift ◽  
Fluorescent Ligands

Serotonin is a neurotransmitter that plays a crucial role in the regulation of several behavioral and cognitive functions by binding to a number of different serotonin receptors present on the cell surface. We report here the synthesis and characterization of several novel fluorescent analogs of serotonin in which the fluorescent NBD (7-nitrobenz-2-oxa-1,3-diazol-4-yl) group is covalently attached to serotonin. The fluorescent ligands compete with the serotonin1A receptor specific radiolabeled agonist for binding to the receptor. Interestingly, these fluorescent ligands display a high environmental sensitivity of their fluorescence. Importantly, the human serotonin1A receptor stably expressed in CHO-K1 cells could be specifically labeled with one of the fluorescent ligands with minimal nonspecific labeling. Interestingly, we show by spectral imaging that the NBD-labeled ligand exhibits a red edge excitation shift (REES) of 29 nm when bound to the receptor, implying that it is localized in a restricted microenvironment. Taken together, our results show that NBD-labeled serotonin analogs offer an attractive fluorescent approach for elucidating the molecular environment of the serotonin binding site in serotonin receptors. In view of the multiple roles played by the serotonergic systems in the central and peripheral nervous systems, these fluorescent ligands would be useful in future studies involving serotonin receptors.

Novel β-galactosidase-specific O2-glycosylated diazeniumdiolate probes

2010 ◽  
Vol 88 (9) ◽  
pp. 969-980 ◽  
Author(s):  
Barry J. Bedell ◽  
D. Scott Bohle ◽  
Zhijie Chua ◽  
Alexander Czerniewski ◽  
Alan C. Evans ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Cell Membranes ◽  
Synthesis And Characterization ◽  
Imaging Agents ◽  
Mri Imaging ◽  
No Donors ◽  
Molecular Mri ◽  
Nitric Oxide Releasing

Three β-galactosidase-specific nitric-oxide-releasing diazeniumdiolate conjugated probes were prepared as a prelude to studies of new potential molecular MRI imaging agents. A glycosylated derivative, 2e, designed to be trafficked across cell membranes, was also prepared. We report, in detail, the synthesis and characterization of these probes. In addition, the release of diazeniumdiolate from the probes by β-galactosidase-catalyzed hydrolysis was used to estimate their efficacy as serum-stable, specific NO donors.

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