scholarly journals Novel Derivatives of 2-Pyridinemethylamine as Selective, Potent, and Orally Active Agonists at 5-HT1AReceptors

1999 ◽  
Vol 42 (9) ◽  
pp. 1648-1660 ◽  
Author(s):  
Bernard Vacher ◽  
Bernard Bonnaud ◽  
Philippe Funes ◽  
Nathalie Jubault ◽  
Wouter Koek ◽  
...  
Keyword(s):  
Orally Active ◽  
Derivatives Of

New Orally Active Derivatives of α-Pyrone possessing Anti-capillary Fragility Activity--III

1961 ◽  
Vol 3 (2) ◽  
pp. 231-240 ◽  
Author(s):  
E. Massarani ◽  
D. Nardi ◽  
P. Mantegazza ◽  
M. Riva ◽  
G. Cavallini
Keyword(s):  
Orally Active ◽  
Derivatives Of

Synthesis and Biological Activity of Various Derivatives of a Novel Class of Potent, Selective, and Orally Active Prostaglandin D2Receptor Antagonists. 1. Bicyclo[2.2.1]heptane Derivatives

2003 ◽  
Vol 46 (12) ◽  
pp. 2436-2445 ◽  
Author(s):  
Susumu Mitsumori ◽  
Tatsuo Tsuri ◽  
Tsunetoshi Honma ◽  
Yoshiharu Hiramatsu ◽  
Toshihiko Okada ◽  
...  
Keyword(s):  
Biological Activity ◽  
Orally Active ◽  
Derivatives Of

Novel, Potent, and Orally Active Substance P Antagonists: Synthesis and Antagonist Activity of N-Benzylcarboxamide Derivatives of Pyrido[3,4-b]pyridine

1995 ◽  
Vol 38 (16) ◽  
pp. 3106-3120 ◽  
Author(s):  
Hideaki Natsugari ◽  
Yoshinori Ikeura ◽  
Yutaka Kiyota ◽  
Yuji Ishichi ◽  
Takenori Ishimaru ◽  
...  
Keyword(s):  
Substance P ◽  
Active Substance ◽  
Antagonist Activity ◽  
Substance P Antagonists ◽  
Orally Active ◽  
Derivatives Of

Nucleic acids. 16. Orally active derivatives of ara-cytidine

1976 ◽  
Vol 19 (8) ◽  
pp. 1013-1017 ◽  
Author(s):  
W. J. Wechter ◽  
D. T. Gish ◽  
M. E. Greig ◽  
G. D. Gray ◽  
T. E. Moxley ◽  
...  
Keyword(s):  
Nucleic Acids ◽  
Orally Active ◽  
Derivatives Of

scholarly journals Gene expression and effects of orally active derivatives of fluoropyrimidine on gastric and colorectal cancer

2010 ◽  
Vol 1 (2) ◽  
pp. 331-336
Author(s):  
SATOSHI ARAKAWA ◽  
SOJI OZAWA ◽  
JIN KAWASE ◽  
HISANORI OSHIMA ◽  
HIDETOSHI NAGATA ◽  
...  
Keyword(s):  
Gene Expression ◽  
Colorectal Cancer ◽  
Orally Active ◽  
Derivatives Of

scholarly journals Antimalarial properties of orally active iron chelators

Blood ◽  
1988 ◽  
Vol 72 (1) ◽  
pp. 358-361
Author(s):  
DG Heppner ◽  
PE Hallaway ◽  
GJ Kontoghiorghes ◽  
JW Eaton
Keyword(s):  
Serum Iron ◽  
Multiple Drug Resistance ◽  
Iron Chelators ◽  
Total Serum ◽  
Multiple Drug ◽  
New Class ◽  
Active Iron ◽  
Iron Pool ◽  
Orally Active ◽  
Derivatives Of

The appearance of widespread multiple drug resistance in human malaria has intensified the search for new antimalarial compounds. Metal chelators, especially those with high affinity for iron, represent one presently unexploited class of antimalarials. Unfortunately the use of previously identified chelators as antimalarials has been precluded by their toxicity and, in the case of desferrioxamine, the necessity for parenteral administration. The investigators now report that a new class of orally active iron chelators, namely the derivatives of alpha- ketohydroxypyridines (KHPs), are potent antimalarials against cultured Plasmodium falciparum. The KHPs evidently exert this effect by sequestering iron because a preformed chelator:iron complex has no antimalarial action. The pool(s) of iron being sequestered by the chelators have not been identified but may not include serum transferrin. Preincubation of human serum with KHPs followed by removal of the drug results in the removal of greater than 97% of total serum iron. Nonetheless, this serum effectively supports the growth of P falciparum cultures. Therefore the KHPs may exert antimalarial effect through chelation of erythrocytic rather than serum iron pool(s). The investigators conclude that these powerful, orally active iron chelators may form the basis of a new class of antimalarial drugs.

ChemInform Abstract: NUCLEIC ACIDS. 16. ORALLY ACTIVE DERIVATIVES OF ARA-CYTIDINE

1976 ◽  
Vol 7 (49) ◽  
pp. no-no
Author(s):  
W. J. WECHTER ◽  
D. T. GISH ◽  
M. E. GREIG ◽  
G. D. GRAY ◽  
T. E. MOXLEY ◽  
...  
Keyword(s):  
Nucleic Acids ◽  
Orally Active ◽  
Derivatives Of

Derivatives of 5-[[1-4(4-carboxybenzyl)imidazolyl]methylidene]hydantoins as orally active angiotensin II receptor antagonists

1995 ◽  
Vol 38 (19) ◽  
pp. 3759-3771 ◽  
Author(s):  
Jeremy J. Edmunds ◽  
Sylvester Klutchko ◽  
James M. Hamby ◽  
Amy M. Bunker ◽  
Cleo J. C. Connolly ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Angiotensin Ii Receptor ◽  
Angiotensin Ii Receptor Antagonists ◽  
Receptor Antagonists ◽  
Orally Active ◽  
Derivatives Of
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