Substituted Isoquinolines and Quinazolines as Potential Antiinflammatory Agents. Synthesis and Biological Evaluation of Inhibitors of Tumor Necrosis Factor α

Qi Chao; Lynn Deng; Hsiencheng Shih; Lorenzo M. Leoni; Davide Genini; Dennis A. Carson; Howard B. Cottam

doi:10.1021/jm9805900

Substituted Isoquinolines and Quinazolines as Potential Antiinflammatory Agents. Synthesis and Biological Evaluation of Inhibitors of Tumor Necrosis Factor α

Journal of Medicinal Chemistry ◽

10.1021/jm9805900 ◽

1999 ◽

Vol 42 (19) ◽

pp. 3860-3873 ◽

Cited By ~ 115

Author(s):

Qi Chao ◽

Lynn Deng ◽

Hsiencheng Shih ◽

Lorenzo M. Leoni ◽

Davide Genini ◽

...

Keyword(s):

Tumor Necrosis Factor ◽

Tumor Necrosis ◽

Tumor Necrosis Factor Α ◽

Biological Evaluation ◽

Antiinflammatory Agents ◽

Factor Α ◽

Synthesis And Biological Evaluation ◽

Necrosis Factor

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Substituted Xanthines, Pteridinediones, and Related Compounds as Potential Antiinflammatory Agents. Synthesis and Biological Evaluation of Inhibitors of Tumor Necrosis Factor α

Journal of Medicinal Chemistry ◽

10.1021/jm940845j ◽

1996 ◽

Vol 39 (1) ◽

pp. 2-9 ◽

Cited By ~ 30

Author(s):

Howard B. Cottam ◽

Hsiencheng Shih ◽

Lida R. Tehrani ◽

D. Bruce Wasson ◽

Dennis A. Carson

Keyword(s):

Tumor Necrosis Factor ◽

Tumor Necrosis ◽

Tumor Necrosis Factor Α ◽

Biological Evaluation ◽

Antiinflammatory Agents ◽

Factor Α ◽

Synthesis And Biological Evaluation ◽

Related Compounds ◽

Necrosis Factor

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ChemInform Abstract: Substituted Xanthines, Pteridinediones, and Related Compounds as Potential Antiinflammatory Agents. Synthesis and Biological Evaluation of Inhibitors of Tumor Necrosis Factor α.

ChemInform ◽

10.1002/chin.199618152 ◽

2010 ◽

Vol 27 (18) ◽

pp. no-no

Author(s):

H. B. COTTAM ◽

H. SHIH ◽

L. R. TEHRANI ◽

D. B. WASSON ◽

D. A. CARSON

Keyword(s):

Tumor Necrosis Factor ◽

Tumor Necrosis ◽

Tumor Necrosis Factor Α ◽

Biological Evaluation ◽

Antiinflammatory Agents ◽

Factor Α ◽

Synthesis And Biological Evaluation ◽

Related Compounds ◽

Necrosis Factor

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Tumor necrosis factor α (TNFα) potentialtes the ion secretion in mouse distal colon

Gastroenterology ◽

10.1016/s0016-5085(01)82636-6 ◽

2001 ◽

Vol 120 (5) ◽

pp. A531-A531

Author(s):

J OPRINS ◽

C BURG ◽

J GROOT

Keyword(s):

Tumor Necrosis Factor ◽

Tumor Necrosis ◽

Tumor Necrosis Factor Α ◽

Distal Colon ◽

Ion Secretion ◽

Factor Α ◽

Necrosis Factor

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Abstract #800: Effects of Atorvastatin and Candesartan on Inflammatory Cytokines Interferon-γ, Tumor Necrosis Factor-α, Interleukin-6, and C-Reactive Protein in Diabetic Patients with Hypertension, Hyperlipidemia, and Cardiac Hypertrophy

Endocrine Practice ◽

10.1016/s1530-891x(20)43653-5 ◽

2005 ◽

Vol 11 ◽

pp. 17-18

Author(s):

Stanley Andrew Tan ◽

Linda Giles Tan

Keyword(s):

Tumor Necrosis Factor ◽

Inflammatory Cytokines ◽

Tumor Necrosis ◽

Tumor Necrosis Factor Α ◽

Interferon Γ ◽

Diabetic Patients ◽

C Reactive Protein ◽

Reactive Protein ◽

Factor Α ◽

Necrosis Factor

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Evidence of a Role of Tumor Necrosis Factor α in Refractory Asthma

Yearbook of Pediatrics ◽

10.1016/s0084-3954(08)70014-9 ◽

2007 ◽

Vol 2007 ◽

pp. 21-23

Author(s):

J.A. Stockman

Keyword(s):

Tumor Necrosis Factor ◽

Tumor Necrosis ◽

Tumor Necrosis Factor Α ◽

Factor Α ◽

Refractory Asthma ◽

Necrosis Factor

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Inhibitory effect of Tumor Necrosis Factor α, Interleukin 2, and Interferon γ on CTGF expression in cultured rat hepatocytes

Zeitschrift für Gastroenterologie ◽

10.1055/s-0029-1191794 ◽

2009 ◽

Vol 47 (01) ◽

Author(s):

I Peredniene ◽

OA Gressner ◽

B Lahme ◽

K Rehbein ◽

AM Gressner

Keyword(s):

Tumor Necrosis Factor ◽

Tumor Necrosis ◽

Tumor Necrosis Factor Α ◽

Interleukin 2 ◽

Rat Hepatocytes ◽

Inhibitory Effect ◽

Interferon Γ ◽

Cultured Rat Hepatocytes ◽

Factor Α ◽

Necrosis Factor

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Study on effect of the tumor necrosis factor–α on onset and progression of obesity in patients with diabetes mellitus

Endocrine Abstracts ◽

10.1530/endoabs.70.ep227 ◽

2020 ◽

Author(s):

Sanobarkhon Irgasheva ◽

Zafar Ibragimov ◽

Elvira Ibragimova ◽

Timur Alimov ◽

Nasiba Alimova ◽

...

Keyword(s):

Diabetes Mellitus ◽

Tumor Necrosis Factor ◽

Tumor Necrosis ◽

Tumor Necrosis Factor Α ◽

Patients With Diabetes ◽

Factor Α ◽

Necrosis Factor

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Induction of Tumor Necrosis Factor–α by UVB: A Role for Reactive Oxygen Intermediates and Eicosanoids¶

Photochemistry and Photobiology ◽

10.1562/0031-8655(2003)078<0068:iotnfb>2.0.co;2 ◽

2003 ◽

Vol 78 (1) ◽

pp. 68 ◽

Cited By ~ 21

Author(s):

Annemie Pupe ◽

Hugo Degreef ◽

Marjan Garmyn

Keyword(s):

Tumor Necrosis Factor ◽

Tumor Necrosis ◽

Tumor Necrosis Factor Α ◽

Reactive Oxygen ◽

Reactive Oxygen Intermediates ◽

Oxygen Intermediates ◽

Factor Α ◽

Necrosis Factor

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Effect of the Biological Drug Etanercept on Tumor necrosis factor-α Levels in Psoriatic Patients

Iraqi Journal of Science ◽

10.24996/ijs.2018.59.2c.2 ◽

2018 ◽

Vol 59 (2C) ◽

Keyword(s):

Tumor Necrosis Factor ◽

Tumor Necrosis ◽

Tumor Necrosis Factor Α ◽

Biological Drug ◽

Factor Α ◽

Necrosis Factor

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Effect of brain-derived neurotrophic factor treatment on behavior and brain serotonin system in tumor necrosis factor-α knockout mice

10.26226/morressier.5971be81d462b80290b52a52 ◽

2017 ◽

Author(s):

Darya Bazovkina

Keyword(s):

Tumor Necrosis Factor ◽

Knockout Mice ◽

Neurotrophic Factor ◽

Tumor Necrosis ◽

Tumor Necrosis Factor Α ◽

Brain Derived Neurotrophic Factor ◽

Brain Serotonin ◽

Serotonin System ◽

Factor Α ◽

Necrosis Factor

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