Synthesis and Biological Properties of Novel Pyridinioalkanoyl Thiolesters (PATE) as Anti-HIV-1 Agents That Target the Viral Nucleocapsid Protein Zinc Fingers

1999 ◽  
Vol 42 (1) ◽  
pp. 67-86 ◽  
Author(s):  
Jim A. Turpin ◽  
Yongsheng Song ◽  
John K. Inman ◽  
Mingjun Huang ◽  
Anders Wallqvist ◽  
...  
Keyword(s):  
Nucleocapsid Protein ◽  
Zinc Fingers ◽  
Biological Properties ◽  
Anti Hiv ◽  
Viral Nucleocapsid ◽  
Hiv 1

Targeting the Viral Nucleocapsid Protein in Anti-HIV-1 Therapy

2008 ◽  
Vol 8 (1) ◽  
pp. 24-35 ◽  
Author(s):  
Yves Mely ◽  
Hugues Rocquigny ◽  
Volodymyr Shvadchak ◽  
Sergiy Avilov ◽  
Chang Dong ◽  
...  
Keyword(s):  
Nucleocapsid Protein ◽  
Anti Hiv ◽  
Viral Nucleocapsid ◽  
Hiv 1

Identification of HIV-1 nucleocapsid protein: nucleic acid antagonists with cellular anti-HIV activity

2002 ◽  
Vol 296 (5) ◽  
pp. 1228-1237 ◽  
Author(s):  
Andrew G Stephen ◽  
Karen M Worthy ◽  
Eric Towler ◽  
Judy A Mikovits ◽  
Shizuko Sei ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Nucleocapsid Protein ◽  
Protein Nucleic Acid ◽  
Anti Hiv ◽  
Hiv 1

ChemInform Abstract: EM2487, a Novel Anti-HIV-1 Antibiotic, Produced by Streptomyces sp. Mer-2487: Taxonomy, Fermentation, Biological Properties, Isolation and Structure Elucidation.

ChemInform ◽  
2010 ◽  
Vol 31 (14) ◽  
pp. no-no
Author(s):  
Hitoshi Takeuchi ◽  
Naoki Asai ◽  
Kazunori Tanabe ◽  
Teruya Kozaki ◽  
Masanori Fujita ◽  
...  
Keyword(s):  
Structure Elucidation ◽  
Biological Properties ◽  
Streptomyces Sp ◽  
Anti Hiv ◽  
Hiv 1

scholarly journals EM2487, a Novel Anti-HIV-1 Antibiotic, Produced by Streptomyces sp. Mer-2487. Taxonomy, Fermentation, Biological Properties, Isolation and Structure Elucidation.

1999 ◽  
Vol 52 (11) ◽  
pp. 971-982 ◽  
Author(s):  
HITOSHI TAKEUCHI ◽  
NAOKI ASAI ◽  
KAZUNORI TANABE ◽  
TERUYA KOZAKI ◽  
MASANORI FUJITA ◽  
...  
Keyword(s):  
Structure Elucidation ◽  
Biological Properties ◽  
Streptomyces Sp ◽  
Anti Hiv ◽  
Hiv 1

scholarly journals 2-Aminothiazolones as Anti-HIV Agents That Act as gp120-CD4 Inhibitors

2014 ◽  
Vol 58 (6) ◽  
pp. 3043-3052 ◽  
Author(s):  
Marika Tiberi ◽  
Cristina Tintori ◽  
Elisa Rita Ceresola ◽  
Roberta Fazi ◽  
Claudio Zamperini ◽  
...  
Keyword(s):  
Early Stage ◽  
Biological Properties ◽  
Docking Simulations ◽  
Protein Protein Interaction ◽  
Entry Inhibitors ◽  
Antiviral Activities ◽  
Hiv Entry ◽  
Anti Hiv Agents ◽  
Anti Hiv ◽  
Hiv 1

ABSTRACTWe report here the synthesis of 2-aminothiazolones along with their biological properties as novel anti-HIV agents. Such compounds have proven to act through the inhibition of the gp120-CD4 protein-protein interaction that occurs at the very early stage of the HIV-1 entry process. No cytotoxicity was found for these compounds, and broad antiviral activities against laboratory strains and pseudotyped viruses were documented. Docking simulations have also been applied to predict the mechanism, at the molecular level, by which the inhibitors were able to interact within the Phe43 cavity of HIV-1 gp120. Furthermore, a preliminary absorption, distribution, metabolism, and excretion (ADME) evaluation was performed. Overall, this study led the basis for the development of more potent HIV entry inhibitors.

The nucleocapsid protein isolated from HIV-1 particles binds zinc and forms retroviral-type zinc fingers

Biochemistry ◽  
1990 ◽  
Vol 29 (34) ◽  
pp. 7786-7789 ◽  
Author(s):  
Terri L. South ◽  
Paul R. Blake ◽  
Raymond C. Sowder ◽  
Larry O. Arthur ◽  
Louis E. Henderson ◽  
...  
Keyword(s):  
Nucleocapsid Protein ◽  
Zinc Fingers ◽  
Hiv 1

scholarly journals Dynamics of Linker Residues Modulate the Nucleic Acid Binding Properties of the HIV-1 Nucleocapsid Protein Zinc Fingers

PLoS ONE ◽  
2014 ◽  
Vol 9 (7) ◽  
pp. e102150 ◽  
Author(s):  
Loussiné Zargarian ◽  
Carine Tisné ◽  
Pierre Barraud ◽  
Xiaoqian Xu ◽  
Nelly Morellet ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Nucleocapsid Protein ◽  
Zinc Fingers ◽  
Nucleic Acid Binding ◽  
Binding Properties ◽  
Hiv 1

scholarly journals Nucleocapsid zinc fingers detected in retroviruses: EXAFS studies of intact viruses and the solution-state structure of the nucleocapsid protein from HIV-1

1992 ◽  
Vol 1 (5) ◽  
pp. 563-574 ◽  
Author(s):  
Michael F. Summers ◽  
Louis E. Henderson ◽  
Mark R. Chance ◽  
Terri L. South ◽  
Paul R. Blake ◽  
...  
Keyword(s):  
Nucleocapsid Protein ◽  
Zinc Fingers ◽  
State Structure ◽  
Solution State ◽  
Hiv 1

scholarly journals Zinc Finger Structures in the Human Immunodeficiency Virus Type 1 Nucleocapsid Protein Facilitate Efficient Minus- and Plus-Strand Transfer

2000 ◽  
Vol 74 (19) ◽  
pp. 8980-8988 ◽  
Author(s):  
Jianhui Guo ◽  
Tiyun Wu ◽  
Jada Anderson ◽  
Bradley F. Kane ◽  
Donald G. Johnson ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Zinc Finger ◽  
Nucleocapsid Protein ◽  
Zinc Fingers ◽  
Strand Transfer ◽  
Minus Strand ◽  
Wild Type ◽  
Immunodeficiency Virus ◽  
Hiv 1

ABSTRACT The nucleocapsid protein (NC) of human immunodeficiency virus type 1 (HIV-1) has two zinc fingers, each containing the invariant metal ion binding residues CCHC. Recent reports indicate that mutations in the CCHC motifs are deleterious for reverse transcription in vivo. To identify reverse transcriptase (RT) reactions affected by such changes, we have probed zinc finger functions in NC-dependent RT-catalyzed HIV-1 minus- and plus-strand transfer model systems. Our approach was to examine the activities of wild-type NC and a mutant in which all six cysteine residues were replaced by serine (SSHS NC); this mutation severely disrupts zinc coordination. We find that the zinc fingers contribute to the role of NC in complete tRNA primer removal from minus-strand DNA during plus-strand transfer. Annealing of the primer binding site sequences in plus-strand strong-stop DNA [(+) SSDNA] to its complement in minus-strand acceptor DNA is not dependent on NC zinc fingers. In contrast, the rate of annealing of the complementary R regions in (−) SSDNA and 3′ viral RNA during minus-strand transfer is approximately eightfold lower when SSHS NC is used in place of wild-type NC. Moreover, unlike wild-type NC, SSHS NC has only a small stimulatory effect on minus-strand transfer and is essentially unable to block TAR-induced self-priming from (−) SSDNA. Our results strongly suggest that NC zinc finger structures are needed to unfold highly structured RNA and DNA strand transfer intermediates. Thus, it appears that in these cases, zinc finger interactions are important components of NC nucleic acid chaperone activity.

scholarly journals Synthesis, Biological Properties and Anti-HIV-1 Activity of New Pyrimidine P1,P2-Dinucleotides

2010 ◽  
Vol 29 (4-6) ◽  
pp. 438-444 ◽  
Author(s):  
A. Miazga ◽  
P. Ziemkowski ◽  
M. A. Siwecka ◽  
A. Lipniacki ◽  
A. Piasek ◽  
...  
Keyword(s):  
Biological Properties ◽  
Anti Hiv ◽  
Hiv 1
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