Tipranavir (PNU-140690):  A Potent, Orally Bioavailable Nonpeptidic HIV Protease Inhibitor of the 5,6-Dihydro-4-hydroxy-2-pyrone Sulfonamide Class∇

1998 ◽  
Vol 41 (18) ◽  
pp. 3467-3476 ◽  
Author(s):  
Steve R. Turner ◽  
Joseph W. Strohbach ◽  
Ruben A. Tommasi ◽  
Paul A. Aristoff ◽  
Paul D. Johnson ◽  
...  
Keyword(s):  
Protease Inhibitor ◽  
Hiv Protease ◽  
Hiv Protease Inhibitor ◽  
Orally Bioavailable

L-735,524: The Design of a Potent and Orally Bioavailable HIV Protease Inhibitor

1994 ◽  
Vol 37 (21) ◽  
pp. 3443-3451 ◽  
Author(s):  
Bruce D. Dorsey ◽  
Rhonda B. Levin ◽  
Stacy L. McDaniel ◽  
Joseph P. Vacca ◽  
James P. Guare ◽  
...  
Keyword(s):  
Protease Inhibitor ◽  
Hiv Protease ◽  
Hiv Protease Inhibitor ◽  
Orally Bioavailable

Altered Myocellular and Abdominal Fat Partitioning Predict Disturbance in Insulin Action in HIV Protease Inhibitor-Related Lipodystrophy

Diabetes ◽  
2002 ◽  
Vol 51 (11) ◽  
pp. 3163-3169 ◽  
Author(s):  
S. K. Gan ◽  
K. Samaras ◽  
C. H. Thompson ◽  
E. W. Kraegen ◽  
A. Carr ◽  
...  
Keyword(s):  
Protease Inhibitor ◽  
Insulin Action ◽  
Abdominal Fat ◽  
Hiv Protease ◽  
Hiv Protease Inhibitor

Identification of the Differentially Expressed Genes Involved in the Synergistic Neurotoxicity of an HIV Protease Inhibitor and Methamphetamine

2019 ◽  
Vol 17 (4) ◽  
pp. 290-303
Author(s):  
Sangsang Li ◽  
Yanfei Li ◽  
Bingpeng Deng ◽  
Jie Yan ◽  
Yong Wang
Keyword(s):  
Protease Inhibitor ◽  
Growth Inhibition ◽  
Quantitative Polymerase Chain Reaction ◽  
Differentially Expressed Gene ◽  
Antiretroviral Drugs ◽  
Differentially Expressed ◽  
Hiv Protease ◽  
Hiv Protease Inhibitor ◽  
Dopaminergic Cells ◽  
Immunodeficiency Syndrome

Background: The abuse of psychostimulants such as methamphetamine (METH) is common in human immunodeficiency virus (HIV)-infected individuals. Acquired immunodeficiency syndrome (AIDS) patients taking METH and antiretroviral drugs could suffer severe neurologic damage and cognitive impairment. Objective: To reveal the underlying neuropathologic mechanisms of an HIV protease inhibitor (PI) combined with METH, growth-inhibition tests of dopaminergic cells and RNA sequencing were performed. Methods: A combination of METH and PI caused more growth inhibition of dopaminergic cells than METH alone or a PI alone. Furthermore, we identified differentially expressed gene (DEG) patterns in the METH vs. untreated cells (1161 genes), PI vs. untreated cells (16 genes), METH-PI vs. PI (3959 genes), and METH-PI vs. METH groups (14 genes). Results: The DEGs in the METH-PI co-treatment group were verified in the brains of a mouse model using quantitative polymerase chain reaction and were involved mostly in the regulatory functions of cell proliferation and inflammation. Conclusion: Such identification of key regulatory genes could facilitate the study of their neuroprotective potential in the users of METH and PIs.

A Practical Synthesis of (1S,2R)-1-Amino-2-indanol, a Key Component of an HIV Protease Inhibitor, Indinavir

1999 ◽  
Vol 72 (5) ◽  
pp. 1093-1100 ◽  
Author(s):  
Hiroshi Kajiro ◽  
Shuichi Mitamura ◽  
Atsunori Mori ◽  
Tamejiro Hiyama
Keyword(s):  
Protease Inhibitor ◽  
Hiv Protease ◽  
Hiv Protease Inhibitor ◽  
Practical Synthesis

scholarly journals HIV protease inhibitor-induced cardiac dysfunction and fibrosis is mediated by platelet-derived TGF-β1 and can be suppressed by exogenous carbon monoxide

PLoS ONE ◽  
2017 ◽  
Vol 12 (10) ◽  
pp. e0187185 ◽  
Author(s):  
Jeffrey Laurence ◽  
Sonia Elhadad ◽  
Tyler Robison ◽  
Hunter Terry ◽  
Rohan Varshney ◽  
...  
Keyword(s):  
Carbon Monoxide ◽  
Protease Inhibitor ◽  
Cardiac Dysfunction ◽  
Hiv Protease ◽  
Hiv Protease Inhibitor ◽  
Tgf Β1

Vanadium(II)- and Niobium(III)-Induced, Diastereoselective Pinacol Coupling of Peptide Aldehydes to Give aC2-Symmetrical HIV Protease Inhibitor

1996 ◽  
Vol 2 (3) ◽  
pp. 307-315 ◽  
Author(s):  
Bernhard Kammermeier ◽  
Gerhard Beck ◽  
Wolfgang Holla ◽  
Detlev Jacobi ◽  
Bernd Napierski ◽  
...  
Keyword(s):  
Protease Inhibitor ◽  
Hiv Protease ◽  
Hiv Protease Inhibitor ◽  
Pinacol Coupling ◽  
Peptide Aldehydes
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