Nonsymmetric P2/P2‘ Cyclic Urea HIV Protease Inhibitors. Structure−Activity Relationship, Bioavailability, and Resistance Profile of Monoindazole-Substituted P2 Analogues

George V. De Lucca; Ui T. Kim; Jing Liang; Beverly Cordova; Ronald M. Klabe; Sena Garber; Lee T. Bacheler; Gilbert N. Lam; Matthew R. Wright; Kelly A. Logue; Susan Erickson-Viitanen; Soo S. Ko; George L. Trainor

doi:10.1021/jm980103g

Nonsymmetric P2/P2‘ Cyclic Urea HIV Protease Inhibitors. Structure−Activity Relationship, Bioavailability, and Resistance Profile of Monoindazole-Substituted P2 Analogues

Journal of Medicinal Chemistry ◽

10.1021/jm980103g ◽

1998 ◽

Vol 41 (13) ◽

pp. 2411-2423 ◽

Cited By ~ 33

Author(s):

George V. De Lucca ◽

Ui T. Kim ◽

Jing Liang ◽

Beverly Cordova ◽

Ronald M. Klabe ◽

...

Keyword(s):

Protease Inhibitors ◽

Structure Activity Relationship ◽

Hiv Protease ◽

Activity Relationship ◽

Hiv Protease Inhibitors ◽

Resistance Profile ◽

Structure Activity

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Quantitative Structure-Activity Relationship Studies on Cyclic Urea-Based HIV Protease Inhibitors

Journal of Enzyme Inhibition ◽

10.3109/14756369809020545 ◽

1998 ◽

Vol 13 (6) ◽

pp. 399-407 ◽

Cited By ~ 12

Author(s):

S. P. Gupta ◽

M. S. Babu ◽

Rajni Garg ◽

S. Sowmya

Keyword(s):

Protease Inhibitors ◽

Quantitative Structure Activity Relationship ◽

Structure Activity Relationship ◽

Hiv Protease ◽

Activity Relationship ◽

Hiv Protease Inhibitors ◽

Quantitative Structure ◽

Structure Activity

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ChemInform Abstract: Stereospecific Synthesis, Structure-Activity Relationship, and Oral Bioavailability of Tetrahydropyrimidin-2-one HIV Protease Inhibitors.

ChemInform ◽

10.1002/chin.199921156 ◽

2010 ◽

Vol 30 (21) ◽

pp. no-no

Author(s):

George V. De Lucca ◽

Jing Liang ◽

Indawati De Lucca

Keyword(s):

Protease Inhibitors ◽

Oral Bioavailability ◽

Structure Activity Relationship ◽

Hiv Protease ◽

Stereospecific Synthesis ◽

Activity Relationship ◽

Hiv Protease Inhibitors ◽

Structure Activity

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Cyclic HIV Protease Inhibitors: Synthesis, Conformational Analysis, P2/P2‘ Structure−Activity Relationship, and Molecular Recognition of Cyclic Ureas

Journal of Medicinal Chemistry ◽

10.1021/jm9602571 ◽

1996 ◽

Vol 39 (18) ◽

pp. 3514-3525 ◽

Cited By ~ 135

Author(s):

Patrick Y. S. Lam ◽

Yu Ru ◽

Prabhakar K. Jadhav ◽

Paul E. Aldrich ◽

George V. DeLucca ◽

...

Keyword(s):

Molecular Recognition ◽

Conformational Analysis ◽

Protease Inhibitors ◽

Structure Activity Relationship ◽

Hiv Protease ◽

Activity Relationship ◽

Hiv Protease Inhibitors ◽

Structure Activity

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Structure-Activity Relationship of Orally Potent Tripeptide-Based HIV Protease Inhibitors Containing Hydroxymethylcarbonyl Isostere.

Chemical and Pharmaceutical Bulletin ◽

10.1248/cpb.48.1310 ◽

2000 ◽

Vol 48 (9) ◽

pp. 1310-1326 ◽

Cited By ~ 28

Author(s):

Tsutomu MIMOTO ◽

Naoko HATTORI ◽

Haruo TAKAKU ◽

Sumitsugu KISANUKI ◽

Tominaga FUKAZAWA ◽

...

Keyword(s):

Protease Inhibitors ◽

Structure Activity Relationship ◽

Hiv Protease ◽

Activity Relationship ◽

Hiv Protease Inhibitors ◽

Structure Activity ◽

Relationship Of

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Structure−Activity Relationship of Small-Sized HIV Protease Inhibitors Containing Allophenylnorstatine

Journal of Medicinal Chemistry ◽

10.1021/jm980637h ◽

1999 ◽

Vol 42 (10) ◽

pp. 1789-1802 ◽

Cited By ~ 53

Author(s):

Tsutomu Mimoto ◽

Ryohei Kato ◽

Haruo Takaku ◽

Satoshi Nojima ◽

Keisuke Terashima ◽

...

Keyword(s):

Protease Inhibitors ◽

Structure Activity Relationship ◽

Hiv Protease ◽

Activity Relationship ◽

Hiv Protease Inhibitors ◽

Structure Activity ◽

Relationship Of

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Lysine derivatives as potent HIV protease inhibitors. Discovery, synthesis and structure–activity relationship studies

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2004.12.068 ◽

2005 ◽

Vol 15 (5) ◽

pp. 1509-1513 ◽

Cited By ~ 2

Author(s):

Abderrahim Bouzide ◽

Gilles Sauvé ◽

Jocelyn Yelle

Keyword(s):

Protease Inhibitors ◽

Structure Activity Relationship ◽

Hiv Protease ◽

Activity Relationship ◽

Hiv Protease Inhibitors ◽

Structure Activity

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Stereospecific Synthesis, Structure−Activity Relationship, and Oral Bioavailability of Tetrahydropyrimidin-2-one HIV Protease Inhibitors

Journal of Medicinal Chemistry ◽

10.1021/jm9803626 ◽

1999 ◽

Vol 42 (1) ◽

pp. 135-152 ◽

Cited By ~ 37

Author(s):

George V. De Lucca ◽

Jing Liang ◽

Indawati De Lucca

Keyword(s):

Protease Inhibitors ◽

Oral Bioavailability ◽

Structure Activity Relationship ◽

Hiv Protease ◽

Stereospecific Synthesis ◽

Activity Relationship ◽

Hiv Protease Inhibitors ◽

Structure Activity

Download Full-text

ChemInform Abstract: Aminodiol HIV Protease Inhibitors. Synthesis and Structure-Activity Relationships of P1/P1′ Compounds: Correlation Between Lipophilicity and Cytotoxicity.

ChemInform ◽

10.1002/chin.199635200 ◽

2010 ◽

Vol 27 (35) ◽

pp. no-no

Author(s):

P. CHEN ◽

P. T. W. CHENG ◽

M. ALAM ◽

B. D. BEYER ◽

G. S. BISACCHI ◽

...

Keyword(s):

Protease Inhibitors ◽

Hiv Protease ◽

Hiv Protease Inhibitors ◽

Structure Activity Relationships ◽

Structure Activity

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ChemInform Abstract: HIV Protease Inhibitory Bis-benzamide Cyclic Ureas: A Quantitative Structure-Activity Relationship Analysis.

ChemInform ◽

10.1002/chin.199705186 ◽

2010 ◽

Vol 28 (5) ◽

pp. no-no

Author(s):

W. W. WILKERSON ◽

E. AKAMIKE ◽

W. W. CHEATHAM ◽

A. Y. HOLLIS ◽

R. D. COLLINS ◽

...

Keyword(s):

Quantitative Structure Activity Relationship ◽

Structure Activity Relationship ◽

Hiv Protease ◽

Activity Relationship ◽

Quantitative Structure ◽

Relationship Analysis ◽

Structure Activity

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Quantitative Structure-Activity Relationship of some HIV-1 Protease Inhibitors: A Fujita-Ban Type Analysis

Journal of Enzyme Inhibition ◽

10.1080/14756360109162368 ◽

2001 ◽

Vol 16 (3) ◽

pp. 185-197 ◽

Cited By ~ 1

Author(s):

S. B. Mekapati ◽

R. Sivakumar ◽

S. P. Gupta

Keyword(s):

Protease Inhibitors ◽

Quantitative Structure Activity Relationship ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Quantitative Structure ◽

Type Analysis ◽

Structure Activity ◽

Relationship Of ◽

Hiv 1

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