Effect of Steroids on DNA Synthesis in an in Vitro Replication System: Initial Quantitative Structure−Activity Relationship Studies and Construction of a Non-Estrogen Receptor Pharmacophore

1998 ◽  
Vol 41 (9) ◽  
pp. 1392-1398 ◽  
Author(s):  
Kamal Azzaoui ◽  
Maria J. Diaz-Perez ◽  
Maria Zannis-Hadjoupoulos ◽  
Gerry B. Price ◽  
Irving W. Wainer
Keyword(s):  
Estrogen Receptor ◽  
Dna Synthesis ◽  
Quantitative Structure Activity Relationship ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Quantitative Structure ◽  
Replication System ◽  
Structure Activity ◽  
In Vitro Replication

scholarly journals Quantitative structure-activity relationship of some 1-benzylbenzimidazole derivatives as antifungal agents

2007 ◽  
pp. 139-147 ◽  
Author(s):  
Sanja Podunavac-Kuzmanovic ◽  
Dijana Barna ◽  
Dragoljub Cvetkovic
Keyword(s):  
Antifungal Activity ◽  
Quantitative Structure Activity Relationship ◽  
Structure Activity Relationship ◽  
Biologically Active ◽  
Activity Relationship ◽  
Quantitative Structure ◽  
Yeast Saccharomyces Cerevisiae ◽  
Structure Activity ◽  
Lipophilicity Parameter

In the present study, the antifungal activity of some 1-benzylbenzimidazole derivatives against yeast Saccharomyces cerevisiae was investigated. The tested benzimidazoles displayed in vitro antifungal activity and minimum inhibitory concentration (MIC) was determined for all the compounds. Quantitative structure-activity relationship (QSAR) has been used to study the relationships between the antifungal activity and lipophilicity parameter, logP, calculated by using CS Chem-Office Software version 7.0. The results are discussed on the basis of statistical data. The best QSAR model for prediction of antifungal activity of the investigated series of benzimidazoles was developed. High agreement between experimental and predicted inhibitory values was obtained. The results of this study indicate that the lipophilicity parameter has a significant effect on antifungal activity of this class of compounds, which simplify design of new biologically active molecules.

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