Excitatory Amino Acid Receptor Ligands:  Resolution, Absolute Stereochemistry, and Enantiopharmacology of 2-Amino-3-(4-butyl-3-hydroxyisoxazol-5-yl)propionic Acid

Tommy N. Johansen; Bjarke Ebert; Hans Bräuner-Osborne; Michael Didriksen; Inge T. Christensen; Karina K. Søby; Ulf Madsen; Povl Krogsgaard-Larsen; Lotte Brehm

doi:10.1021/jm9706731

Excitatory Amino Acid Receptor Ligands: Resolution, Absolute Stereochemistry, and Enantiopharmacology of 2-Amino-3-(4-butyl-3-hydroxyisoxazol-5-yl)propionic Acid

Journal of Medicinal Chemistry ◽

10.1021/jm9706731 ◽

1998 ◽

Vol 41 (6) ◽

pp. 930-939 ◽

Cited By ~ 18

Author(s):

Tommy N. Johansen ◽

Bjarke Ebert ◽

Hans Bräuner-Osborne ◽

Michael Didriksen ◽

Inge T. Christensen ◽

...

Keyword(s):

Amino Acid ◽

Propionic Acid ◽

Excitatory Amino Acid ◽

Receptor Ligands ◽

Excitatory Amino Acid Receptor ◽

Acid Receptor ◽

Absolute Stereochemistry

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Excitatory amino acid receptor ligands: Asymmetric synthesis, absolute stereochemistry and pharmacology of (R)- and (S)-homoibotenic acid

Bioorganic & Medicinal Chemistry ◽

10.1016/0968-0896(95)00044-h ◽

1995 ◽

Vol 3 (5) ◽

pp. 553-558 ◽

Cited By ~ 12

Author(s):

F. Bischoff ◽

T.N. Johansen ◽

B. Ebert ◽

P. Krogsgaard-Larsen ◽

U. Madsen

Keyword(s):

Amino Acid ◽

Asymmetric Synthesis ◽

Excitatory Amino Acid ◽

Receptor Ligands ◽

Excitatory Amino Acid Receptor ◽

Acid Receptor ◽

Absolute Stereochemistry

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ChemInform Abstract: Excitatory Amino-Acid Receptor Agonists. Synthesis and Pharmacology of Analogues of 2-Amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic Acid.

ChemInform ◽

10.1002/chin.199739149 ◽

2010 ◽

Vol 28 (39) ◽

pp. no-no

Author(s):

F. A. SLOEK ◽

B. EBERT ◽

Y. LANG ◽

P. KROGSGAARD-LARSEN ◽

S. M. LENZ ◽

...

Keyword(s):

Amino Acid ◽

Propionic Acid ◽

Excitatory Amino Acid ◽

Excitatory Amino Acid Receptor ◽

Acid Receptor ◽

Receptor Agonists

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ChemInform Abstract: Ionotropic Excitatory Amino Acid Receptor Ligands. Synthesis and Pharmacology of a New Amino Acid AMPA Antagonist.

ChemInform ◽

10.1002/chin.200025135 ◽

2010 ◽

Vol 31 (25) ◽

pp. no-no

Author(s):

Ulf Madsen ◽

Frank A. Sloek ◽

Tine B. Stensboel ◽

Hans Braeuner-Osborne ◽

Hans-Christian H. Luetzhoeft ◽

...

Keyword(s):

Amino Acid ◽

Excitatory Amino Acid ◽

Receptor Ligands ◽

Excitatory Amino Acid Receptor ◽

Acid Receptor ◽

Ampa Antagonist

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Excitatory amino acid receptor antagonists: Resolution, absolute stereochemistry, and pharmacology of (S)- and (R)-2-amino-2-(5-tert-butyl-3-hydroxyisoxazol-4-yl)acetic acid (ATAA)

Chirality ◽

10.1002/(sici)1520-636x(1997)9:5/6<529::aid-chir20>3.0.co;2-p ◽

1997 ◽

Vol 9 (5-6) ◽

pp. 529-536 ◽

Cited By ~ 6

Author(s):

Tommy N. Johansen ◽

Karla Frydenvang ◽

Bjarke Ebert ◽

Ulf Madsen ◽

Povl Krogsgaard-Larsen

Keyword(s):

Acetic Acid ◽

Amino Acid ◽

Excitatory Amino Acid ◽

Receptor Antagonists ◽

Excitatory Amino Acid Receptor ◽

Acid Receptor ◽

Tert Butyl ◽

Absolute Stereochemistry

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1,4-Dihydro-2,3-quinoxalinediones as potential flavin metabolites and excitatory amino acid receptor ligands. Part 1: Synthesis and pharmacological evaluation of the benzylic oxidation series of 1,4-dihydro-6,7-dimethyl-2,3-quinoxalinedione

Bioorganic & Medicinal Chemistry ◽

10.1016/s0968-0896(97)10032-3 ◽

1998 ◽

Vol 6 (3) ◽

pp. 271-282 ◽

Cited By ~ 9

Author(s):

Ajita Bhat ◽

Hui-Min Chang ◽

Lane J Wallace ◽

David M Weinstein ◽

Gamal Shams ◽

...

Keyword(s):

Amino Acid ◽

Excitatory Amino Acid ◽

Receptor Ligands ◽

Excitatory Amino Acid Receptor ◽

Acid Receptor ◽

Pharmacological Evaluation ◽

Benzylic Oxidation

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Excitatory amino acid receptor ligands. Synthesis and biological activity of 3-isoxazolol amino acids structurally related to homoibotenic acid

Journal of Medicinal Chemistry ◽

10.1021/jm00097a008 ◽

1992 ◽

Vol 35 (19) ◽

pp. 3512-3519 ◽

Cited By ~ 20

Author(s):

Inge T. Christensen ◽

Bjarke Ebert ◽

Ulf Madsen ◽

Birgitte Nielsen ◽

Lotte Brehm ◽

...

Keyword(s):

Amino Acids ◽

Biological Activity ◽

Amino Acid ◽

Excitatory Amino Acid ◽

Receptor Ligands ◽

Excitatory Amino Acid Receptor ◽

Acid Receptor

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Magnesium prevents seizure-induced reduction in excitatory amino acid receptor (kainate and α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid) binding in pregnant rat brain

American Journal of Obstetrics and Gynecology ◽

10.1067/mob.2000.109491 ◽

2000 ◽

Vol 183 (4) ◽

pp. 793-798 ◽

Cited By ~ 6

Author(s):

Mordechai Hallak ◽

John W. Hotra ◽

Don Custodio ◽

Michael L. Kruger

Keyword(s):

Amino Acid ◽

Rat Brain ◽

Propionic Acid ◽

Excitatory Amino Acid ◽

Pregnant Rat ◽

Excitatory Amino Acid Receptor ◽

Acid Receptor

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Ionotropic excitatory amino acid receptor ligands. Synthesis and pharmacology of a new amino acid AMPA antagonist

European Journal of Medicinal Chemistry ◽

10.1016/s0223-5234(00)00104-5 ◽

2000 ◽

Vol 35 (1) ◽

pp. 69-76 ◽

Cited By ~ 12

Author(s):

U Madsen

Keyword(s):

Amino Acid ◽

Excitatory Amino Acid ◽

Receptor Ligands ◽

Excitatory Amino Acid Receptor ◽

Acid Receptor ◽

Ampa Antagonist

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Excitatory amino-acid receptor agonists. Synthesis and pharmacology of analogues of 2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid

European Journal of Medicinal Chemistry ◽

10.1016/s0223-5234(97)89085-x ◽

1997 ◽

Vol 32 (4) ◽

pp. 329-338 ◽

Cited By ~ 23

Author(s):

F.A. Sløk ◽

B Ebert ◽

Y Lang ◽

P Krogsgaard-Larsen ◽

S.M. Lenz ◽

...

Keyword(s):

Amino Acid ◽

Propionic Acid ◽

Excitatory Amino Acid ◽

Excitatory Amino Acid Receptor ◽

Acid Receptor ◽

Receptor Agonists

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Displacement of excitatory amino acid receptor ligands by acidic oligopeptides

Neurochemical Research ◽

10.1007/bf00965513 ◽

1989 ◽

Vol 14 (12) ◽

pp. 1223-1227 ◽

Cited By ~ 29

Author(s):

V. Varga ◽

R. Janáky ◽

K. -M. Marnela ◽

J. Gulyás ◽

P. Kontro ◽

...

Keyword(s):

Amino Acid ◽

Excitatory Amino Acid ◽

Receptor Ligands ◽

Excitatory Amino Acid Receptor ◽

Acid Receptor

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