Identification and Initial Structure−Activity Relationships of (R)-5-(2-Azetidinylmethoxy)-2-chloropyridine (ABT-594), a Potent, Orally Active, Non-Opiate Analgesic Agent Acting via Neuronal Nicotinic Acetylcholine Receptors

1998 ◽  
Vol 41 (4) ◽  
pp. 407-412 ◽  
Author(s):  
Mark W. Holladay ◽  
James T. Wasicak ◽  
Nan-Horng Lin ◽  
Yun He ◽  
Keith B. Ryther ◽  
...  
Keyword(s):  
Nicotinic Acetylcholine Receptors ◽  
Acetylcholine Receptors ◽  
Initial Structure ◽  
Neuronal Nicotinic Acetylcholine Receptors ◽  
Analgesic Agent ◽  
Nicotinic Acetylcholine ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
Orally Active ◽  
Opiate Analgesic

Potentiation and inhibition of subtypes of neuronal nicotinic acetylcholine receptors by Pb2+

1995 ◽  
Vol 291 (3) ◽  
pp. 399-406 ◽  
Author(s):  
Ruud Zwart ◽  
Regina G.D.M. Van Kleef ◽  
Jacob M. Milikan ◽  
Marga Oortgiesen ◽  
Henk P.M. Vijverberg
Keyword(s):  
Nicotinic Acetylcholine Receptors ◽  
Acetylcholine Receptors ◽  
Neuronal Nicotinic Acetylcholine Receptors ◽  
Nicotinic Acetylcholine
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