Synthesis of Analogs of 2-Methoxyestradiol with Enhanced Inhibitory Effects on Tubulin Polymerization and Cancer Cell Growth

1997 ◽  
Vol 40 (15) ◽  
pp. 2323-2334 ◽  
Author(s):  
Mark Cushman ◽  
Hu-Ming He ◽  
John A. Katzenellenbogen ◽  
Ravi K. Varma ◽  
Ernest Hamel ◽  
...  
Keyword(s):  
Cell Growth ◽  
Cancer Cell ◽  
Tubulin Polymerization ◽  
Inhibitory Effects ◽  
Cancer Cell Growth

ChemInform Abstract: Synthesis of Analogues of 2-Methoxyestradiol with Enhanced Inhibitory Effects on Tubulin Polymerization and Cancer Cell Growth.

ChemInform ◽  
2010 ◽  
Vol 28 (48) ◽  
pp. no-no
Author(s):  
M. CUSHMAN ◽  
H.-M. HE ◽  
J. A. KATZENELLENBOGEN ◽  
R. K. VARMA ◽  
E. HAMEL ◽  
...  
Keyword(s):  
Cell Growth ◽  
Cancer Cell ◽  
Tubulin Polymerization ◽  
Inhibitory Effects ◽  
Cancer Cell Growth

Enhancing the Cancer Cell Growth Inhibitory Effects of Table Grape Anthocyanins

2018 ◽  
Vol 83 (9) ◽  
pp. 2369-2374 ◽  
Author(s):  
Karnell L. Grimes ◽  
Connor M. Stuart ◽  
Justin J. McCarthy ◽  
Baljinder Kaur ◽  
Emilio J. Cantu ◽  
...  
Keyword(s):  
Cell Growth ◽  
Cancer Cell ◽  
Table Grape ◽  
Inhibitory Effects ◽  
Cancer Cell Growth ◽  
Growth Inhibitory

Role of gene regulation in the anticancer activity of carotenoids

2002 ◽  
Vol 74 (8) ◽  
pp. 1469-1477 ◽  
Author(s):  
Yoav Sharoni ◽  
Michael Danilenko ◽  
Shlomo Walfisch ◽  
Hadar Amir ◽  
Amit Nahum ◽  
...  
Keyword(s):  
Cell Growth ◽  
Cancer Cell ◽  
Fruits And Vegetables ◽  
Cancer Cell Proliferation ◽  
Inhibitory Effects ◽  
Cancer Cell Growth ◽  
Cyclin Dependent Kinases ◽  
Synergistic Inhibition ◽  
Powerful Means

There is extensive evidence that high intake of fruits and vegetables is associated with decreased risk of many types of cancers. Thus, it is widely accepted that diet changes are a powerful means to prevent cancer. Although there is a growing interest in the role of the tomato carotenoid lycopene in cancer prevention and treatment, we hypothesize that a single micronutrient cannot replace the power of the concerted action of multiple agents derived from a diet rich in fruits and vegetables. Indeed, we found that lycopene can synergize with other phytonutrients in the inhibition of cancer cell growth. The mechanism underlying the inhibitory effects of lycopene and other carotenoids involves interference in several pathways related to cancer cell proliferation and includes changes in the expression of many proteins participating in these processes, such as connexins, cyclins, cyclin-dependent kinases, and their inhibitors. These changes in protein expression suggest that the initial effect involves modulation of transcription by ligand-activated nuclear receptors or by other transcription factors. It is feasible to suggest that carotenoids and their oxidized derivatives interact with a network of transcription systems that are activated by different ligands at low affinity and specificity and that this activation leads to the synergistic inhibition of cell growth.

Peptide YY augments the inhibitory effects of alpha-tocopherol succinate on prostate cancer cell growth

2000 ◽  
Vol 118 (4) ◽  
pp. A1409
Author(s):  
Amy T. Rose ◽  
Tracy Heisler ◽  
Shirin Towfigh ◽  
Natalie Simon ◽  
David W. McFadden
Keyword(s):  
Prostate Cancer ◽  
Cell Growth ◽  
Cancer Cell ◽  
Prostate Cancer Cell ◽  
Peptide Yy ◽  
Alpha Tocopherol ◽  
Inhibitory Effects ◽  
Cancer Cell Growth

Evaluation of ligustrazine based synthetic compounds for mechanism based antiproliferative effects

2020 ◽  
Vol 16 ◽  
Author(s):  
Syed Nasir Abbas Bukhari ◽  
Nasser Hadal Alotaibi ◽  
Waqas Ahmad ◽  
Khalid Saad Alharbi ◽  
Mohamed A. Abdelgawad ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Cancer Cell ◽  
Biological Activities ◽  
Tubulin Polymerization ◽  
Inhibitory Effects ◽  
Cancer Cell Growth ◽  
Synthetic Compounds ◽  
Antiproliferative Effects ◽  
Anticancer Effects ◽  
Synthetic Derivatives

Background: Ligustrazine and chalcones have been reported previously for various biological activities including anticancer effects. Objectives: Based on the multitargeted biological activities approach of ligustrazine based chalcones, in current study 18 synthetic ligustrazine-containing α, β-unsaturated carbonyl-based 1, 3-Diphenyl-2-propen-1-one derivatives were evaluated for their inhibitory effects on growth of five different types of cancer cells. Methods: All compounds were evaluated for anticancer effects on various cancer cell lines by propidium iodide fluorescence assay and various other assays were performed for mechanistic studies. Results: Majority of compounds exhibited strong inhibition of cancer cells especially synthetic compounds 4a and 4b bearing 1-Pyridin-3-yl-ethanone as a ketone moiety in main structural backbone were found most powerful inhibitors of cancer cell growth. Most active 9 compounds among whole series were selected for further studies related to different cancer targets including EGFR TK kinases, tubulin polymerization, KAF and BRAFV600E. Conclusion: Synthetic derivatives including 4a-b and 5a-b showed multitarget approach and showed strong inhibitory effects on EGFR, FAK and BRAF while three compounds including 3e bearing methoxy substitution, 4a and 4b with 1- pyridin-3-yl-ethanone moiety showed the inhibition of tubulin polymerization.

scholarly journals Inhibitory effects of norcantharidin against human lung cancer cell growth and migration

2010 ◽  
Vol 62 (4) ◽  
pp. 349-355 ◽  
Author(s):  
Jinling Luan ◽  
Huiying Duan ◽  
Qian Liu ◽  
Kazumi Yagasaki ◽  
Guoying Zhang
Keyword(s):  
Lung Cancer ◽  
Cell Growth ◽  
Cancer Cell ◽  
Human Lung ◽  
Human Lung Cancer ◽  
Inhibitory Effects ◽  
Lung Cancer Cell ◽  
Cancer Cell Growth ◽  
Cell Growth And Migration ◽  
And Migration

Inhibitory Effects of Diacylglyceride Phospholipids on DNA Polymerase and Topoisomerase Activities, and Human Cancer Cell Growth

2010 ◽  
Vol 6 (3) ◽  
pp. 114-122 ◽  
Author(s):  
Chisato Ishimaru ◽  
Toshifumi Takeuchi ◽  
Fumio Sugawara ◽  
Hiromi Yoshida ◽  
Yoshiyuki Mizushina
Keyword(s):  
Cell Growth ◽  
Cancer Cell ◽  
Dna Polymerase ◽  
Human Cancer ◽  
Human Cancer Cell ◽  
Inhibitory Effects ◽  
Cancer Cell Growth
Sign in / Sign up

Export Citation Format

Share Document