Structure−Activity Relationships of Alkyl- and Alkoxy-Substituted 1,4-Dihydroquinoxaline-2,3-diones:  Potent and Systemically Active Antagonists for the Glycine Site of the NMDA Receptor

Sui Xiong Cai; Sunil M. Kher; Zhang-Lin Zhou; Victor Ilyin; Stephen A. Espitia; Minhtam Tran; Jon E. Hawkinson; Richard M. Woodward; Eckard Weber; John F. W. Keana

doi:10.1021/jm960654b

Structure−Activity Relationships of Alkyl- and Alkoxy-Substituted 1,4-Dihydroquinoxaline-2,3-diones: Potent and Systemically Active Antagonists for the Glycine Site of the NMDA Receptor

Journal of Medicinal Chemistry ◽

10.1021/jm960654b ◽

1997 ◽

Vol 40 (5) ◽

pp. 730-738 ◽

Cited By ~ 33

Author(s):

Sui Xiong Cai ◽

Sunil M. Kher ◽

Zhang-Lin Zhou ◽

Victor Ilyin ◽

Stephen A. Espitia ◽

...

Keyword(s):

Nmda Receptor ◽

Glycine Site ◽

Structure Activity Relationships ◽

Structure Activity

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Synthesis and Structure−Activity Relationships of 1,2,3,4-Tetrahydroquinoline-2,3,4-trione 3-Oximes: Novel and Highly Potent Antagonists for NMDA Receptor Glycine Site

Journal of Medicinal Chemistry ◽

10.1021/jm960214k ◽

1996 ◽

Vol 39 (17) ◽

pp. 3248-3255 ◽

Cited By ~ 28

Author(s):

Sui Xiong Cai ◽

Zhang-Lin Zhou ◽

Jin-Cheng Huang ◽

Edward R. Whittemore ◽

Zizi O. Egbuwoku ◽

...

Keyword(s):

Nmda Receptor ◽

Glycine Site ◽

Structure Activity Relationships ◽

Structure Activity

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Drug Design, in Vitro Pharmacology, and Structure−Activity Relationships of 3-Acylamino-2-aminopropionic Acid Derivatives, a Novel Class of Partial Agonists at the Glycine Site on theN-Methyl-d-aspartate (NMDA) Receptor Complex

Journal of Medicinal Chemistry ◽

10.1021/jm900363q ◽

2009 ◽

Vol 52 (16) ◽

pp. 5093-5107 ◽

Cited By ~ 16

Author(s):

Stephan Urwyler ◽

Philipp Floersheim ◽

Bernard L. Roy ◽

Manuel Koller

Keyword(s):

Nmda Receptor ◽

Drug Design ◽

Receptor Complex ◽

Glycine Site ◽

Structure Activity Relationships ◽

Partial Agonists ◽

Structure Activity ◽

Nmda Receptor Complex ◽

In Vitro Pharmacology

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ChemInform Abstract: Synthesis and Structure-Activity Relationships of 1,2,3,4- Tetrahydroquinoline-2,3,4-trione 3-Oximes: Novel and Highly Potent Antagonists for NMDA Receptor Glycine Site.

ChemInform ◽

10.1002/chin.199649166 ◽

2010 ◽

Vol 27 (49) ◽

pp. no-no

Author(s):

S. X. CAI ◽

Z.-L. ZHOU ◽

J.-C. HUANG ◽

E. R. WHITTEMORE ◽

Z. O. EGBUWOKU ◽

...

Keyword(s):

Nmda Receptor ◽

Glycine Site ◽

Structure Activity Relationships ◽

Structure Activity

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4-Amido-2-carboxytetrahydroquinolines. Structure-activity relationships for antagonism at the glycine site of the NMDA receptor

Journal of Medicinal Chemistry ◽

10.1021/jm00089a004 ◽

1992 ◽

Vol 35 (11) ◽

pp. 1954-1968 ◽

Cited By ~ 134

Author(s):

Paul D. Leeson ◽

Robert W. Carling ◽

Kevin W. Moore ◽

Angela M. Moseley ◽

Julian D. Smith ◽

...

Keyword(s):

Nmda Receptor ◽

Glycine Site ◽

Structure Activity Relationships ◽

Structure Activity

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The Glycine Site on the NMDA Receptor: Structure-Activity Relationships and Therapeutic Potential

Journal of Medicinal Chemistry ◽

10.1021/jm00050a001 ◽

1994 ◽

Vol 37 (24) ◽

pp. 4053-4067 ◽

Cited By ~ 233

Author(s):

Paul D. Leeson ◽

Leslie L. Iversen

Keyword(s):

Nmda Receptor ◽

Therapeutic Potential ◽

Glycine Site ◽

Structure Activity Relationships ◽

Receptor Structure ◽

Structure Activity

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Quantitative Structure-Activity Relationships of Noncompetitive Antagonists of the NMDA Receptor: A Study of a Series of MK801 Derivative Molecules Using Statistical Methods and Neural Network

International Journal of Molecular Sciences ◽

10.3390/i4050249 ◽

2003 ◽

Vol 4 (5) ◽

pp. 249-262 ◽

Cited By ~ 8

Author(s):

M. Elhallaoui ◽

M. Elasri ◽

F. Ouazzani ◽

A. Mechaqrane ◽

T. Lakhlifi

Keyword(s):

Neural Network ◽

Nmda Receptor ◽

Statistical Methods ◽

Quantitative Structure ◽

Structure Activity Relationships ◽

Structure Activity ◽

Quantitative Structure Activity Relationships

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6-(1H-Imidazol-1-yl)-7-nitro-2,3(1H,4H)-quinoxalinedione (YM90K) and Related Compounds: Structure−Activity Relationships for the AMPA-Type Non-NMDA Receptor

Journal of Medicinal Chemistry ◽

10.1021/jm960757u ◽

1997 ◽

Vol 40 (5) ◽

pp. 826-826

Author(s):

Junya Ohmori ◽

Shuichi Sakamoto ◽

Hirokazu Kubota ◽

Masao Shimizu-Sasamata ◽

Masamichi Okada ◽

...

Keyword(s):

Nmda Receptor ◽

Structure Activity Relationships ◽

Structure Activity ◽

Related Compounds

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8-(1H-Imidazol-1-yl)-7-nitro-4(5H)-imidazo[1,2-a]quinoxalinone and Related Compounds: Synthesis and Structure−Activity Relationships for the AMPA-type Non-NMDA Receptor

Journal of Medicinal Chemistry ◽

10.1021/jm960664c ◽

1997 ◽

Vol 40 (13) ◽

pp. 2053-2063 ◽

Cited By ~ 52

Author(s):

Junya Ohmori ◽

Masao Shimizu-Sasamata ◽

Masamichi Okada ◽

Shuichi Sakamoto

Keyword(s):

Nmda Receptor ◽

Structure Activity Relationships ◽

Structure Activity ◽

Related Compounds

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Structure-activity relationships of tricyclic quinoxalinediones as potent antagonists for the glycine binding site of the NMDA receptor 2

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/0960-894x(95)00244-n ◽

1995 ◽

Vol 5 (14) ◽

pp. 1533-1536 ◽

Cited By ~ 10

Author(s):

Ryu Nagata ◽

Toru Kodo ◽

Hiroshi Yamaguchi ◽

Norihiko Tanno

Keyword(s):

Nmda Receptor ◽

Binding Site ◽

Structure Activity Relationships ◽

Structure Activity

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Synthesis and Structure−Activity Relationships of 6,7-Benzomorphan Derivatives as Antagonists of the NMDA Receptor−Channel Complex

Journal of Medicinal Chemistry ◽

10.1021/jm970131j ◽

1997 ◽

Vol 40 (18) ◽

pp. 2922-2930 ◽

Cited By ~ 14

Author(s):

Matthias Grauert ◽

Wolf Dietrich Bechtel ◽

Helmut A. Ensinger ◽

Herbert Merz ◽

Adrian J. Carter

Keyword(s):

Nmda Receptor ◽

Structure Activity Relationships ◽

Structure Activity ◽

Nmda Receptor Channel ◽

Receptor Channel

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