Structure−Activity Relationships in a Series of Orally Active γ-Hydroxy Butenolide Endothelin Antagonists

William C. Patt; Jeremy J. Edmunds; Joseph T. Repine; Kent A. Berryman; Billy R. Reisdorph; Chet Lee; Mark S. Plummer; Aurash Shahripour; Stephen J. Haleen; Joan A. Keiser; Mike A. Flynn; Kathleen M. Welch; Elwood E. Reynolds; Ron Rubin; Brian Tobias; Hussein Hallak; Annette M. Doherty

doi:10.1021/jm9606507

Structure−Activity Relationships in a Series of Orally Active γ-Hydroxy Butenolide Endothelin Antagonists

Journal of Medicinal Chemistry ◽

10.1021/jm9606507 ◽

1997 ◽

Vol 40 (7) ◽

pp. 1063-1074 ◽

Cited By ~ 39

Author(s):

William C. Patt ◽

Jeremy J. Edmunds ◽

Joseph T. Repine ◽

Kent A. Berryman ◽

Billy R. Reisdorph ◽

...

Keyword(s):

Structure Activity Relationships ◽

Structure Activity ◽

Endothelin Antagonists ◽

Orally Active

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Biphenylsulfonamide Endothelin Antagonists: Structure−Activity Relationships of a Series of Mono- and Disubstituted Analogues and Pharmacology of the Orally Active Endothelin Antagonist 2‘-Amino-N- (3,4-dimethyl-5-isoxazolyl)-4‘-(2-methylpropyl)[1,1‘-biphenyl]-2-sulfonamide (BMS-187308)

Journal of Medicinal Chemistry ◽

10.1021/jm970872k ◽

1998 ◽

Vol 41 (26) ◽

pp. 5198-5218 ◽

Cited By ~ 22

Author(s):

Natesan Murugesan ◽

Zhengxiang Gu ◽

Philip D. Stein ◽

Sharon Bisaha ◽

Steve Spergel ◽

...

Keyword(s):

Structure Activity Relationships ◽

Structure Activity ◽

Endothelin Antagonists ◽

Orally Active ◽

Endothelin Antagonist

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Synthesis and structure-activity relationships of pyrimidine derivatives as potent and orally active FGFR3 inhibitors with both increased systemic exposure and enhanced in vitro potency

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2021.116019 ◽

2021 ◽

Vol 33 ◽

pp. 116019

Author(s):

Ikumi Kuriwaki ◽

Minoru Kameda ◽

Kazuhiko Iikubo ◽

Hiroyuki Hisamichi ◽

Yuichiro Kawamoto ◽

...

Keyword(s):

Systemic Exposure ◽

Pyrimidine Derivatives ◽

Structure Activity Relationships ◽

Structure Activity ◽

Orally Active

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Design of 2,5-Dimethyl-3-(6-dimethyl-4-methylpyridin-3-yl)-7-dipropylaminopyrazolo[1,5-a]pyrimidine (NBI 30775/R121919) and Structure−Activity Relationships of a Series of Potent and Orally Active Corticotropin-Releasing Factor Receptor Antagonists

Journal of Medicinal Chemistry ◽

10.1021/jm040058e ◽

2004 ◽

Vol 47 (19) ◽

pp. 4787-4798 ◽

Cited By ~ 91

Author(s):

Chen ◽

Keith M. Wilcoxen ◽

Charles Q. Huang ◽

Yun-Feng Xie ◽

James R. McCarthy ◽

...

Keyword(s):

Corticotropin Releasing Factor ◽

Receptor Antagonists ◽

Structure Activity Relationships ◽

Structure Activity ◽

Orally Active

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ChemInform Abstract: Orally Active Cephalosporins. Part 4. Synthesis, Structure-Activity Relationships and Oral Absorption of Novel 3-(4-Pyrazolylmethylthio)cephalosporins with Various C-7 Side Chains.

ChemInform ◽

10.1002/chin.200221193 ◽

2010 ◽

Vol 33 (21) ◽

pp. no-no

Author(s):

Hirofumi Yamamoto ◽

Yoshiteru Eikyu ◽

Shinya Okuda ◽

Kohji Kawabata ◽

Hisashi Takasugi ◽

...

Keyword(s):

Oral Absorption ◽

Side Chains ◽

Structure Activity Relationships ◽

Structure Activity ◽

Orally Active

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Orally active cephalosporins. III. Synthesis and structure-activity relationships of new 3-heterocyclicthiomethylthio-7.BETA.-((Z)-2(2-aminothiazol-4-yl)-2-hydroxyiminoacetamido)-3-cephem-4-carboxylic acids.

The Journal of Antibiotics ◽

10.7164/antibiotics.46.316 ◽

1993 ◽

Vol 46 (2) ◽

pp. 316-330 ◽

Cited By ~ 2

Author(s):

MASAHARU KUME ◽

TADATOSHI KUBOTA ◽

YASUO KIMURA ◽

HIROMU NAKASHIMIZU ◽

KIYOSHI MOTOKAWA

Keyword(s):

Carboxylic Acids ◽

Structure Activity Relationships ◽

Structure Activity ◽

Orally Active

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Corrigendum to “Design, synthesis, and structure–activity relationships of a series of novel N-aryl-2-phenylcyclopropanecarboxamide that are potent and orally active orexin receptor antagonists” [Bioorg. Med. Chem. 22 (2014) 6071–6088]

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2015.04.042 ◽

2015 ◽

Vol 23 (13) ◽

pp. 3870

Author(s):

Yu Yoshida ◽

Taro Terauchi ◽

Yoshimitsu Naoe ◽

Yuji Kazuta ◽

Fumihiro Ozaki ◽

...

Keyword(s):

Receptor Antagonists ◽

Design Synthesis ◽

Structure Activity Relationships ◽

Structure Activity ◽

Orally Active

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Orally active cephalosporins. Part 3: synthesis, structure–activity relationships and oral absorption of novel C-3 heteroarylmethylthio cephalosporins

Bioorganic & Medicinal Chemistry ◽

10.1016/s0968-0896(00)00266-2 ◽

2001 ◽

Vol 9 (2) ◽

pp. 465-475 ◽

Cited By ~ 12

Author(s):

Hirofumi Yamamoto ◽

Takeshi Terasawa ◽

Ayako Nakamura ◽

Kohji Kawabata ◽

Hisashi Takasugi ◽

...

Keyword(s):

Oral Absorption ◽

Structure Activity Relationships ◽

Structure Activity ◽

Orally Active

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Synthesis, structure–activity relationships, and anticonvulsant activities of 2-amino-4H-pyrido[3,2-e][1,3]thiazin-4-one derivatives as orally active AMPA receptor antagonists

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2015.02.033 ◽

2015 ◽

Vol 23 (8) ◽

pp. 1788-1799 ◽

Cited By ~ 5

Author(s):

Hiroshi Inami ◽

Jun-ichi Shishikura ◽

Tomoyuki Yasunaga ◽

Kazushige Ohno ◽

Hiroshi Yamashita ◽

...

Keyword(s):

Ampa Receptor ◽

Receptor Antagonists ◽

Structure Activity Relationships ◽

Structure Activity ◽

Anticonvulsant Activities ◽

Orally Active

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Discovery and structure–activity relationships of 6-(benzoylamino)benzoxaboroles as orally active anti-inflammatory agents

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2013.08.096 ◽

2013 ◽

Vol 23 (21) ◽

pp. 5870-5873 ◽

Cited By ~ 13

Author(s):

Tsutomu Akama ◽

Chen Dong ◽

Charlotte Virtucio ◽

Yvonne R. Freund ◽

Daitao Chen ◽

...

Keyword(s):

Structure Activity Relationships ◽

Structure Activity ◽

Anti Inflammatory ◽

Orally Active

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ChemInform Abstract: Studies on Orally Active Cephalosporins. Part 1. Synthesis and Structure-Activity Relationships of New 3-Substituted Carbamoyloxymethyl Cephalosporins.

ChemInform ◽

10.1002/chin.199523260 ◽

2010 ◽

Vol 26 (23) ◽

pp. no-no

Author(s):

S. NEGI ◽

M. YAMANAKA ◽

I. SUGIYAMA ◽

Y. KOMATSU ◽

M. SASHO ◽

...

Keyword(s):

Structure Activity Relationships ◽

Structure Activity ◽

Orally Active

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