Synthesis and Structure−Activity Relationship of a New Series of Potent AT1Selective Angiotensin II Receptor Antagonists:  5-(Biphenyl-4-ylmethyl)pyrazoles

Carmen Almansa; Luis A. Gómez; Fernando L. Cavalcanti; Alberto F. de Arriba; Julián García-Rafanell; Javier Forn

doi:10.1021/jm9604383

Synthesis and Structure−Activity Relationship of a New Series of Potent AT1Selective Angiotensin II Receptor Antagonists: 5-(Biphenyl-4-ylmethyl)pyrazoles

Journal of Medicinal Chemistry ◽

10.1021/jm9604383 ◽

1997 ◽

Vol 40 (4) ◽

pp. 547-558 ◽

Cited By ~ 60

Author(s):

Carmen Almansa ◽

Luis A. Gómez ◽

Fernando L. Cavalcanti ◽

Alberto F. de Arriba ◽

Julián García-Rafanell ◽

...

Keyword(s):

Angiotensin Ii ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Angiotensin Ii Receptor ◽

Angiotensin Ii Receptor Antagonists ◽

Receptor Antagonists ◽

Structure Activity ◽

Relationship Of

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Synthesis and Structure-Activity Relationship of a New Series of Potent Angiotensin II Receptor Antagonists: Pyrazolo(1,5-a)pyrimidine Derivatives.

Chemical and Pharmaceutical Bulletin ◽

10.1248/cpb.47.928 ◽

1999 ◽

Vol 47 (7) ◽

pp. 928-938 ◽

Cited By ~ 21

Author(s):

Takeshi SHIOTA ◽

Teruo YAMAMORI ◽

Katsunori SAKAI ◽

Mitsugu KIYOKAWA ◽

Tsunetoshi HONMA ◽

...

Keyword(s):

Angiotensin Ii ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Angiotensin Ii Receptor ◽

Angiotensin Ii Receptor Antagonists ◽

Pyrimidine Derivatives ◽

Receptor Antagonists ◽

Structure Activity ◽

Relationship Of

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ChemInform Abstract: Synthesis and Structure-Activity Relationship of a New Series of Potent Angiotensin II Receptor Antagonists: Pyrazolo[1,5-a]pyrimidine Derivatives.

ChemInform ◽

10.1002/chin.199949141 ◽

2010 ◽

Vol 30 (49) ◽

pp. no-no

Author(s):

Takeshi Shiota ◽

et al. et al.

Keyword(s):

Angiotensin Ii ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Angiotensin Ii Receptor ◽

Angiotensin Ii Receptor Antagonists ◽

Pyrimidine Derivatives ◽

Receptor Antagonists ◽

Structure Activity ◽

Relationship Of

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New non-peptide angiotensin II receptor antagonists. 2: structure - activity relationship of a series of annelated 2(1H)-pyridinones

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/s0960-894x(01)81134-3 ◽

1994 ◽

Vol 4 (1) ◽

pp. 127-132 ◽

Cited By ~ 4

Author(s):

John R. Bantick ◽

Haydn G. Beaton ◽

Sally L. Cooper ◽

Stephen Hill ◽

Simon C. Hirst ◽

...

Keyword(s):

Angiotensin Ii ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Angiotensin Ii Receptor ◽

Angiotensin Ii Receptor Antagonists ◽

Receptor Antagonists ◽

Structure Activity ◽

Relationship Of

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ChemInform Abstract: Synthesis and Structure-Activity Relationship of a New Series of Potent AT1 Selective Angiotensin II Receptor Antagonists: 5-(Biphenyl- 4-ylmethyl)pyrazoles.

ChemInform ◽

10.1002/chin.199722147 ◽

2010 ◽

Vol 28 (22) ◽

pp. no-no

Author(s):

C. ALMANSA ◽

L. A. GOMEZ ◽

F. L. CAVALCANTI ◽

A. F. DE ARRIBA ◽

J. GARCIA-RAFANELL ◽

...

Keyword(s):

Angiotensin Ii ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Angiotensin Ii Receptor ◽

Angiotensin Ii Receptor Antagonists ◽

Receptor Antagonists ◽

Structure Activity ◽

Relationship Of

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Comprehensive structure–activity relationship analysis of substituted 5-(biphenyl-4-ylmethyl) pyrazoles derivatives as AT1 selective angiotensin II receptor antagonists: 2D and kNNMFA QSAR approach

Medicinal Chemistry Research ◽

10.1007/s00044-012-0206-8 ◽

2012 ◽

Vol 22 (5) ◽

pp. 2124-2138 ◽

Cited By ~ 12

Author(s):

Mukesh C. Sharma ◽

D. V. Kohli

Keyword(s):

Angiotensin Ii ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Angiotensin Ii Receptor ◽

Angiotensin Ii Receptor Antagonists ◽

Receptor Antagonists ◽

Relationship Analysis ◽

Structure Activity

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WITHDRAWN: Comprehensive structure–activity relationship analysis of isoxazolinyl and isoxazolidinyl substituted quinazolinone derivatives as angiotensin II receptor antagonists

Journal of Saudi Chemical Society ◽

10.1016/j.jscs.2012.04.012 ◽

2012 ◽

Cited By ~ 9

Author(s):

Mukesh C. Sharma ◽

D.V. Kohli

Keyword(s):

Angiotensin Ii ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Angiotensin Ii Receptor ◽

Angiotensin Ii Receptor Antagonists ◽

Receptor Antagonists ◽

Relationship Analysis ◽

Structure Activity ◽

Quinazolinone Derivatives

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Molecular Modeling and Quantitative Structure—Activity Relationship Studies in Pursuit of Highly Potent Substituted Octanoamide Angiotensin II Receptor Antagonists

ACS Symposium Series - Computer-Aided Molecular Design ◽

10.1021/bk-1995-0589.ch002 ◽

1995 ◽

pp. 14-35 ◽

Cited By ~ 4

Author(s):

Donald B. Boyd ◽

Alan D. Palkowitz ◽

K. Jeff Thrasher ◽

Kenneth L. Hauser ◽

Celia A. Whitesitt ◽

...

Keyword(s):

Molecular Modeling ◽

Angiotensin Ii ◽

Quantitative Structure Activity Relationship ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Quantitative Structure ◽

Angiotensin Ii Receptor ◽

Angiotensin Ii Receptor Antagonists ◽

Receptor Antagonists ◽

Structure Activity

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The conformation and activity relationship of benzofuran derivatives as angiotensin II receptor antagonists

Bioorganic & Medicinal Chemistry ◽

10.1016/s0968-0896(96)00244-1 ◽

1997 ◽

Vol 5 (2) ◽

pp. 445-459 ◽

Cited By ~ 15

Author(s):

Sung-eun Yoo ◽

Seung-Heui Lee ◽

Soo-Kyung Kim ◽

Sung-Hou Lee

Keyword(s):

Angiotensin Ii ◽

Activity Relationship ◽

Angiotensin Ii Receptor ◽

Angiotensin Ii Receptor Antagonists ◽

Receptor Antagonists ◽

Relationship Of

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A Structure–Activity Relationship Study of Imidazole-5-Carboxylic Acid Derivatives as Angiotensin II Receptor Antagonists Combining 2D and 3D QSAR Methods

Interdisciplinary Sciences Computational Life Sciences ◽

10.1007/s12539-015-0014-1 ◽

2015 ◽

Vol 8 (1) ◽

pp. 1-10 ◽

Cited By ~ 2

Author(s):

Mukesh C. Sharma

Keyword(s):

Angiotensin Ii ◽

Carboxylic Acid ◽

3D Qsar ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Angiotensin Ii Receptor ◽

Angiotensin Ii Receptor Antagonists ◽

Structure Activity ◽

Relationship Study ◽

2D And 3D

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The Conformation and Activity Relationship of Benzofuran Type of Angiotensin II Receptor Antagonists

Bioorganic & Medicinal Chemistry ◽

10.1016/s0968-0896(00)00164-4 ◽

2000 ◽

Vol 8 (9) ◽

pp. 2311-2316 ◽

Cited By ~ 17

Author(s):

Sung-eun Yoo ◽

Soo-Kyung Kim ◽

Sung-Hou Lee ◽

Nak-Jung Kim ◽

Dai-Woon Lee

Keyword(s):

Angiotensin Ii ◽

Activity Relationship ◽

Angiotensin Ii Receptor ◽

Angiotensin Ii Receptor Antagonists ◽

Receptor Antagonists ◽

Relationship Of

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