Structure−Activity Relationships in a Series of Substituted Indolocarbazoles:  Topoisomerase I and Protein Kinase C Inhibition and Antitumoral and Antimicrobial Properties

1996 ◽  
Vol 39 (22) ◽  
pp. 4471-4477 ◽  
Author(s):  
Elisabète Rodrigues Pereira ◽  
Laure Belin ◽  
Martine Sancelme ◽  
Michelle Prudhomme ◽  
Monique Ollier ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Topoisomerase I ◽  
Antimicrobial Properties ◽  
Structure Activity Relationships ◽  
Kinase C ◽  
Structure Activity

Design, synthesis, and structure–activity relationship of new isobenzofuranone ligands of protein kinase C

2004 ◽  
Vol 14 (11) ◽  
pp. 2963-2967 ◽  
Author(s):  
Yoshiyasu Baba ◽  
Yosuke Ogoshi ◽  
Go Hirai ◽  
Takeshi Yanagisawa ◽  
Kumiko Nagamatsu ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Design Synthesis ◽  
Kinase C ◽  
Structure Activity ◽  
Relationship Of

scholarly journals Macrocyclic Diterpenoids from Euphorbiaceae as A Source of Potent and Selective Inhibitors of Chikungunya Virus Replication

Molecules ◽  
2019 ◽  
Vol 24 (12) ◽  
pp. 2336 ◽  
Author(s):  
Simon Remy ◽  
Marc Litaudon
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Virus Replication ◽  
Mechanism Of Action ◽  
Chikungunya Virus ◽  
Cytopathic Effect ◽  
Structural Diversity ◽  
Biological Properties ◽  
Kinase C ◽  
Structure Activity

Macrocyclic diterpenoids produced by plants of the Euphorbiaceae family are of considerable interest due to their high structural diversity; and their therapeutically relevant biological properties. Over the last decade many studies have reported the ability of macrocyclic diterpenoids to inhibit in cellulo the cytopathic effect induced by the chikungunya virus. This review; which covers the years 2011 to 2019; lists all macrocyclic diterpenoids that have been evaluated for their ability to inhibit viral replication. The structure–activity relationships and the probable involvement of protein kinase C in their mechanism of action are also detailed.

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