Structure−Activity Studies of 6-Substituted Decahydroisoquinoline-3-carboxylic Acid AMPA Receptor Antagonists. 2. Effects of Distal Acid Bioisosteric Substitution, Absolute Stereochemical Preferences, and in Vivo Activity

Paul L. Ornstein; M. Brian Arnold; Nancy K. Allen; Thomas Bleisch; Peter S. Borromeo; Charles W. Lugar; J. David Leander; David Lodge; Darryle D. Schoepp

doi:10.1021/jm950913h

Structure−Activity Studies of 6-Substituted Decahydroisoquinoline-3-carboxylic Acid AMPA Receptor Antagonists. 2. Effects of Distal Acid Bioisosteric Substitution, Absolute Stereochemical Preferences, and in Vivo Activity

Journal of Medicinal Chemistry ◽

10.1021/jm950913h ◽

1996 ◽

Vol 39 (11) ◽

pp. 2232-2244 ◽

Cited By ~ 25

Author(s):

Paul L. Ornstein ◽

M. Brian Arnold ◽

Nancy K. Allen ◽

Thomas Bleisch ◽

Peter S. Borromeo ◽

...

Keyword(s):

Carboxylic Acid ◽

Ampa Receptor ◽

Receptor Antagonists ◽

Structure Activity

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ChemInform Abstract: Structure-Activity Studies of 6-(Tetrazolylalkyl)-Substituted Decahydroisoquinoline-3-carboxylic Acid AMPA Receptor Antagonists. Part 1. Effects of Stereochemistry, Chain Length, and Chain Substitution.

ChemInform ◽

10.1002/chin.199637201 ◽

2010 ◽

Vol 27 (37) ◽

pp. no-no

Author(s):

P. L. ORNSTEIN ◽

M. B. ARNOLD ◽

N. K. ALLEN ◽

T. BLEISCH ◽

P. S. BORROMEO ◽

...

Keyword(s):

Carboxylic Acid ◽

Chain Length ◽

Ampa Receptor ◽

Receptor Antagonists ◽

Structure Activity ◽

Abstract Structure

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Synthesis and Structure—Activity Relationship of 4,10-Dihydro-4-oxo-4H-imidazo[1,2-a]indeno[1,2-e]pyrazine Derivatives: Highly Potent and Selective AMPA Receptor Antagonists with in vivo Activity

ChemInform ◽

10.1002/chin.200451232 ◽

2004 ◽

Vol 35 (51) ◽

Author(s):

Jean-Marie Stutzmann ◽

Marc Vuilhorgne ◽

Serge Mignani

Keyword(s):

Ampa Receptor ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Receptor Antagonists ◽

Structure Activity ◽

Relationship Of

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Structure−Activity Studies of 6-(Tetrazolylalkyl)-Substituted Decahydroisoquinoline-3-carboxylic Acid AMPA Receptor Antagonists. 1. Effects of Stereochemistry, Chain Length, and Chain Substitution

Journal of Medicinal Chemistry ◽

10.1021/jm950912p ◽

1996 ◽

Vol 39 (11) ◽

pp. 2219-2231 ◽

Cited By ~ 30

Author(s):

Paul L. Ornstein ◽

M. Brian Arnold ◽

Nancy K. Allen ◽

Thomas Bleisch ◽

Peter S. Borromeo ◽

...

Keyword(s):

Carboxylic Acid ◽

Chain Length ◽

Ampa Receptor ◽

Receptor Antagonists ◽

Structure Activity

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Structure-activity studies of aryl-spaced decahydroisoquinoline-3-carboxylic acid ampa receptor antagonists

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/s0960-894x(97)00185-6 ◽

1997 ◽

Vol 7 (9) ◽

pp. 1161-1166 ◽

Cited By ~ 20

Author(s):

Thomas J. Bleisch ◽

Paul L. Ornstein ◽

Nancy K. Allen ◽

Rebecca A. Wright ◽

David Lodge ◽

...

Keyword(s):

Carboxylic Acid ◽

Ampa Receptor ◽

Receptor Antagonists ◽

Structure Activity

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Synthesis and Structure-Activity Relationships of 4,10-Dihydro-4-oxo-4HImidazo[ 1,2-a]Indeno[1,2-e]Pyrazine Derivatives: Highly Potent and Selective AMPA Receptor Antagonists with In Vivo Activity

Mini-Reviews in Medicinal Chemistry ◽

10.2174/1389557043487411 ◽

2004 ◽

Vol 4 (2) ◽

pp. 123-140 ◽

Cited By ~ 4

Author(s):

Jean-Marie Stutzmann ◽

Marc Vuilhorgne ◽

Serge Mignani

Keyword(s):

Ampa Receptor ◽

Receptor Antagonists ◽

Structure Activity Relationships ◽

Structure Activity

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Nonpeptide angiotensin II receptor antagonists. 2. Design, synthesis, and structure-activity relationships of 2-alkyl-4-(1H-pyrrol-l-yl)-1H-imidazole derivatives: profile of 2-propyl-1-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-4-[2-(trifluoroacetyl)-1H-pyrrol-1-yl]-1H-imidazole-5-carboxylic acid (CI-996)

Journal of Medicinal Chemistry ◽

10.1021/jm00068a002 ◽

1993 ◽

Vol 36 (16) ◽

pp. 2253-2265 ◽

Cited By ~ 9

Author(s):

Ila Sircar ◽

John C. Hodges ◽

John Quin ◽

Amy M. Bunker ◽

R. Thomas Winters ◽

...

Keyword(s):

Angiotensin Ii ◽

Carboxylic Acid ◽

Angiotensin Ii Receptor ◽

Angiotensin Ii Receptor Antagonists ◽

Receptor Antagonists ◽

Design Synthesis ◽

Structure Activity Relationships ◽

Imidazole Derivatives ◽

Structure Activity

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Structure−Activity Relationships of a Novel Class of Endothelin-A Receptor Antagonists and Discovery of Potent and Selective Receptor Antagonist, 2-(Benzo[1,3]dioxol-5-yl)-6-isopropyloxy-4-(4-methoxyphenyl)-2H-chromene-3- carboxylic Acid (S-1255). 1. Study on Structure−Activity Relationships and Basic Structure Crucial for ETAAntagonism

Journal of Medicinal Chemistry ◽

10.1021/jm010382z ◽

2002 ◽

Vol 45 (10) ◽

pp. 2041-2055 ◽

Cited By ~ 60

Author(s):

Natsuki Ishizuka ◽

Ken-ichi Matsumura ◽

Katsunori Sakai ◽

Masafumi Fujimoto ◽

Shin-ichi Mihara ◽

...

Keyword(s):

Carboxylic Acid ◽

Receptor Antagonist ◽

Basic Structure ◽

Receptor Antagonists ◽

Structure Activity Relationships ◽

Structure Activity ◽

Endothelin A Receptor ◽

Endothelin A

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Quinazolin-4-one α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Antagonists: Structure−Activity Relationship of the C-2 Side Chain Tether

Journal of Medicinal Chemistry ◽

10.1021/jm000522p ◽

2001 ◽

Vol 44 (11) ◽

pp. 1710-1717 ◽

Cited By ~ 34

Author(s):

Bertrand L. Chenard ◽

Willard M. Welch ◽

James F. Blake ◽

Todd W. Butler ◽

Anthony Reinhold ◽

...

Keyword(s):

Ampa Receptor ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Side Chain ◽

Receptor Antagonists ◽

Structure Activity ◽

Relationship Of

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Synthesis and structure–activity relationships of carboxylic acid derivatives of pyridoxal as P2X receptor antagonists

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2013.01.073 ◽

2013 ◽

Vol 21 (9) ◽

pp. 2643-2650 ◽

Cited By ~ 7

Author(s):

Kwan-Young Jung ◽

Joong-Heui Cho ◽

Jung Sun Lee ◽

Hyo Jun Kim ◽

Yong-Chul Kim

Keyword(s):

Carboxylic Acid ◽

P2x Receptor ◽

Receptor Antagonists ◽

Structure Activity Relationships ◽

Structure Activity ◽

Derivatives Of

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Synthesis, structure–activity relationships, and anticonvulsant activities of 2-amino-4H-pyrido[3,2-e][1,3]thiazin-4-one derivatives as orally active AMPA receptor antagonists

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2015.02.033 ◽

2015 ◽

Vol 23 (8) ◽

pp. 1788-1799 ◽

Cited By ~ 5

Author(s):

Hiroshi Inami ◽

Jun-ichi Shishikura ◽

Tomoyuki Yasunaga ◽

Kazushige Ohno ◽

Hiroshi Yamashita ◽

...

Keyword(s):

Ampa Receptor ◽

Receptor Antagonists ◽

Structure Activity Relationships ◽

Structure Activity ◽

Anticonvulsant Activities ◽

Orally Active

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