6- and 7-Substituted 2-[2‘-(Dimethylamino)ethyl]-1,2-dihydro-3H- dibenz[de,h]isoquinoline-1,3-diones:  Synthesis, Nucleophilic Displacements, Antitumor Activity, and Quantitative Structure−Activity Relationships

Salah M. Sami; Robert T. Dorr; Anikó M. Sólyom; David S. Alberts; Bhashyam S. Iyengar; William A. Remers

doi:10.1021/jm950742g

6- and 7-Substituted 2-[2‘-(Dimethylamino)ethyl]-1,2-dihydro-3H- dibenz[de,h]isoquinoline-1,3-diones: Synthesis, Nucleophilic Displacements, Antitumor Activity, and Quantitative Structure−Activity Relationships

Journal of Medicinal Chemistry ◽

10.1021/jm950742g ◽

1996 ◽

Vol 39 (8) ◽

pp. 1609-1618 ◽

Cited By ~ 22

Author(s):

Salah M. Sami ◽

Robert T. Dorr ◽

Anikó M. Sólyom ◽

David S. Alberts ◽

Bhashyam S. Iyengar ◽

...

Keyword(s):

Antitumor Activity ◽

Quantitative Structure ◽

Structure Activity Relationships ◽

Structure Activity ◽

Quantitative Structure Activity Relationships

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2-[2‘-(Dimethylamino)ethyl]-1,2-dihydro-3H-dibenz[de,h]isoquinoline-1,3-diones with Substituents at Positions 4, 8, 9, 10, and 11. Synthesis, Antitumor Activity, and Quantitative Structure−Activity Relationships

Journal of Medicinal Chemistry ◽

10.1021/jm970322m ◽

1997 ◽

Vol 40 (16) ◽

pp. 2660-2660

Author(s):

Salah M. Sami ◽

Robert T. Dorr ◽

David S. Alberts ◽

Anikó M. Sólyom ◽

William A. Remers

Keyword(s):

Antitumor Activity ◽

Quantitative Structure ◽

Structure Activity Relationships ◽

Structure Activity ◽

Quantitative Structure Activity Relationships

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2-[2‘-(Dimethylamino)ethyl]-1,2-dihydro-3H-dibenz[de,h]isoquinoline-1,3-diones with Substituents at Positions 4, 8, 9, 10, and 11. Synthesis, Antitumor Activity, and Quantitative Structure−Activity Relationships

Journal of Medicinal Chemistry ◽

10.1021/jm960623g ◽

1996 ◽

Vol 39 (25) ◽

pp. 4978-4987 ◽

Cited By ~ 30

Author(s):

Salah M. Sami ◽

Robert T. Dorr ◽

David S. Alberts ◽

Anikó M. Sólyom ◽

William A. Remers

Keyword(s):

Antitumor Activity ◽

Quantitative Structure ◽

Structure Activity Relationships ◽

Structure Activity ◽

Quantitative Structure Activity Relationships

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Quantitative Structure Activity Relationships of Anthracycline Antitumor Activity and Cardiac Toxicity Based Upon Intercalation Calculations

The Jerusalem Symposia on Quantum Chemistry and Biochemistry - Intermolecular Forces ◽

10.1007/978-94-015-7658-1_27 ◽

1981 ◽

pp. 431-444 ◽

Cited By ~ 7

Author(s):

A. J. Hopfinger ◽

Y. Nakata ◽

N. Max

Keyword(s):

Antitumor Activity ◽

Cardiac Toxicity ◽

Quantitative Structure ◽

Structure Activity Relationships ◽

Structure Activity ◽

Quantitative Structure Activity Relationships

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ChemInform Abstract: POTENTIAL ANTITUMOR AGENTS. 33. QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIPS S FOR MUTAGENIC ACTIVITY AND ANTITUMOR ACTIVITY OF SUBSTITUTED 4′-(9-ACRIDINYLAMINO)METHANESULFONANILIDE DERIVATIVES

Chemischer Informationsdienst ◽

10.1002/chin.198033228 ◽

1980 ◽

Vol 11 (33) ◽

Author(s):

L. R. FERGUSON ◽

W. A. DENNY

Keyword(s):

Antitumor Activity ◽

Antitumor Agents ◽

Mutagenic Activity ◽

Quantitative Structure ◽

Structure Activity Relationships ◽

Structure Activity ◽

Quantitative Structure Activity Relationships ◽

Potential Antitumor

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ChemInform Abstract: 2-(2′-(Dimethylamino)ethyl)-1,2-dihydro-3H-dibenz(de,h)isoquinoline-1, 3-diones with Substituents at Positions 4, 8, 9, 10, and 11. Synthesis, Antitumor Activity, and Quantitative Structure-Activity Relationships.

ChemInform ◽

10.1002/chin.199714122 ◽

2010 ◽

Vol 28 (14) ◽

pp. no-no

Author(s):

S. M. SAMI ◽

R. T. DORR ◽

D. S. ALBERTS ◽

A. M. SOLYOM ◽

W. A. REMERS

Keyword(s):

Antitumor Activity ◽

Quantitative Structure ◽

Structure Activity Relationships ◽

Structure Activity ◽

Quantitative Structure Activity Relationships

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Quantitative structure activity relationships (QSAR) for antitumor activity of nitroazoles: a comparative analysis for the parent compounds and their nitroanione radical and nitrosoanione radical derivatives

5th Korea-Russia International Symposium on Science and Technology. Proceedings. KORUS 2001 (Cat. No.01EX478) ◽

10.1109/korus.2001.975012 ◽

2005 ◽

Author(s):

A. Khlebnikov ◽

I. Schepetkin ◽

Byung Sam Kim ◽

Byoung Se Kwon

Keyword(s):

Comparative Analysis ◽

Antitumor Activity ◽

Quantitative Structure ◽

Structure Activity Relationships ◽

Structure Activity ◽

Quantitative Structure Activity Relationships

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Potential antitumor agents. 33. Quantitative structure-activity relationships for mutagenic activity and antitumor activity of substituted 4'-(9-acridinylamino)methanesulfonanilide derivatives

Journal of Medicinal Chemistry ◽

10.1021/jm00177a011 ◽

1980 ◽

Vol 23 (3) ◽

pp. 269-274 ◽

Cited By ~ 44

Author(s):

Lynnette R. Ferguson ◽

William A. Denny

Keyword(s):

Antitumor Activity ◽

Antitumor Agents ◽

Mutagenic Activity ◽

Quantitative Structure ◽

Structure Activity Relationships ◽

Structure Activity ◽

Quantitative Structure Activity Relationships ◽

Potential Antitumor

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Quantitative Structure-Activity Relationships of Potential Antimalarial Drugs Active Against Chloroquine-Resistant Plasmodium Falciparum

Planta Medica ◽

10.1055/s-2008-1075144 ◽

2008 ◽

Vol 74 (03) ◽

Author(s):

SJ Hocart ◽

H Liu ◽

D De ◽

FM Krogstad ◽

DJ Krogstad

Keyword(s):

Plasmodium Falciparum ◽

Antimalarial Drugs ◽

Quantitative Structure ◽

Structure Activity Relationships ◽

Structure Activity ◽

Quantitative Structure Activity Relationships

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Parabolic Quantitative Structure–Activity Relationships and Photodynamic Therapy: Application of a Three-Compartment Model with Clearance to the In Vivo Quantitative Structure–Activity Relationships of a Congeneric Series of Pyropheophorbide Derivatives Used as Photosensitizers for Photodynamic Therapy

Photochemistry and Photobiology ◽

10.1562/0031-8655(1999)070<0781:pqsrap>2.3.co;2 ◽

1999 ◽

Vol 70 (5) ◽

pp. 781 ◽

Cited By ~ 2

Author(s):

W. R. Potter ◽

B. W. Henderson ◽

D. A. Bellnier ◽

R. K. Pandey ◽

L. A. Vaughan ◽

...

Keyword(s):

Photodynamic Therapy ◽

Compartment Model ◽

Quantitative Structure ◽

Structure Activity Relationships ◽

Structure Activity ◽

Three Compartment Model ◽

Quantitative Structure Activity Relationships

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Binding Affinity of Triphenyl Acrylonitriles to Estrogen Receptors: Quantitative Structure-Activity Relationships

Folia Medica ◽

10.2478/v10153-010-0005-2 ◽

2010 ◽

Vol 52 (3) ◽

Cited By ~ 1

Author(s):

Sorana Bolboacă ◽

Monica Marta ◽

Lorentz Jäntschi

Keyword(s):

Estrogen Receptors ◽

Binding Affinity ◽

Quantitative Structure ◽

Structure Activity Relationships ◽

Structure Activity ◽

Quantitative Structure Activity Relationships

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