Somatostatin Receptor-Binding Peptides Labeled with Technetium-99m:  Chemistry and Initial Biological Studies

1996 ◽  
Vol 39 (7) ◽  
pp. 1361-1371 ◽  
Author(s):  
Daniel A. Pearson ◽  
John Lister-James ◽  
William J. McBride ◽  
David M. Wilson ◽  
Lawrence J. Martel ◽  
...  
Keyword(s):  
Receptor Binding ◽  
Somatostatin Receptor ◽  
Technetium 99M ◽  
Biological Studies ◽  
Binding Peptides

Somatostatin Receptor-Binding Peptides Suitable for Tumor Radiotherapy with Re-188 or Re-186. Chemistry and Initial Biological Studies

2007 ◽  
Vol 50 (6) ◽  
pp. 1354-1364 ◽  
Author(s):  
John E. Cyr ◽  
Daniel A. Pearson ◽  
David M. Wilson ◽  
Carol A. Nelson ◽  
Mary Guaraldi ◽  
...  
Keyword(s):  
Receptor Binding ◽  
Somatostatin Receptor ◽  
Biological Studies ◽  
Binding Peptides

Lung cancer - from radiodiagnosis to radiotherapy with novel somatostatin-receptor-binding peptides

2000 ◽  
Vol 21 (6) ◽  
pp. 590
Author(s):  
R. Manchanda ◽  
M. T. Azure ◽  
D. A. Pearson ◽  
D. M. Wilson ◽  
B. R. Moyer ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Receptor Binding ◽  
Somatostatin Receptor ◽  
Binding Peptides

scholarly journals Neurotransmitter and Receptor Deficits in Senile Dementia of the Alzheimer Type

1986 ◽  
Vol 13 (S4) ◽  
pp. 503-510 ◽  
Author(s):  
R. Quirion ◽  
J.C. Martel ◽  
Y. Robitaille ◽  
P. Etienne ◽  
P. Wood ◽  
...  
Keyword(s):  
Neuropeptide Y ◽  
Receptor Binding ◽  
Binding Sites ◽  
Senile Dementia ◽  
Somatostatin Receptor ◽  
Brain Regions ◽  
Nucleus Basalis ◽  
Nicotinic Cholinergic Receptors ◽  
Senile Dementia Of The

Abstract:Multiple neurotransmitter systems are affected in senile dementia of the Alzheimer's type (SDAT). Among them, acetylcholine has been most studied. It is now well accepted that the activity of the enzyme, choline acetyltransferase (ChAT) is much decreased in various brain regions including the frontal and temporal cortices, hippocampus and nucleus basalis of Meynert (nbm) in SDAT. Cortical M2-muscarinic and nicotinic cholinergic receptors are also decreased but only in a certain proportion (30-40%) of SDAT patients. For other systems, it appears that cortical serotonin (5-HT)-type 2 receptor binding sites are decreased in SDAT. This diminution in 5-HT2 receptors correlates well with the decreased levels of somatostatin-like immunoreactive materials found in the cortex of SDAT patients. Cortical somatostatin receptor binding sites are decreased in about one third of SDAT patients. Finally, neuropeptide Y and neuropeptide Y receptor binding sites are distributed in areas enriched in cholinergic cell bodies and nerve fiber terminals and it would be of interest to determine possible involvement of this peptide in SDAT. Thus, it appears that multi-drug clinical trials should be considered for the treatment of SDAT.

scholarly journals Synthesis, characterization and biological studies of rhenium, technetium-99m and rhenium-188 pentapeptides

2019 ◽  
Vol 68-69 ◽  
pp. 1-13 ◽  
Author(s):  
Vanessa A. Sanders ◽  
David Iskhakov ◽  
Dalya Abdel-Atti ◽  
Matthew Devany ◽  
Michelle C. Neary ◽  
...  
Keyword(s):  
Technetium 99M ◽  
Biological Studies

Structural modification of receptor-binding technetium-99m complexes in order to improve brain uptake

1997 ◽  
Vol 24 (3) ◽  
pp. 316-319 ◽  
Author(s):  
Bernd Johannsen ◽  
Ralf Berger ◽  
Peter Brust ◽  
Hans-Juergen Pietzsch ◽  
Matthias Scheunemann ◽  
...  
Keyword(s):  
Receptor Binding ◽  
Structural Modification ◽  
Brain Uptake ◽  
Technetium 99M

High-throughput receptor-binding methods for somatostatin receptor 2

2002 ◽  
Vol 307 (1) ◽  
pp. 159-166 ◽  
Author(s):  
Elizabeth T Birzin ◽  
Susan P Rohrer
Keyword(s):  
Receptor Binding ◽  
High Throughput ◽  
Somatostatin Receptor

Somatostatin receptor-effector system in rat pancreatic acinar membranes after subtotal enterectomy

1995 ◽  
Vol 268 (2) ◽  
pp. E343-E348
Author(s):  
I. Alvaro-Alonso ◽  
B. Colas ◽  
J. P. Esteve ◽  
C. Susini ◽  
E. Arilla
Keyword(s):  
Small Bowel ◽  
Receptor Binding ◽  
Protein Interactions ◽  
Bowel Resection ◽  
Somatostatin Receptor ◽  
Small Bowel Resection ◽  
Receptor Binding Site ◽  
Proximal Small Bowel ◽  
Effector System ◽  
Receptor Number

In the present study we found that exocrine pancreatic hyperplasia observed after proximal small bowel resection is accompanied by an increase in pancreatic somatostatin (SS) content at 1 mo and an increase in the number of SS receptors at 2 wk and 1 mo after intestinal surgery. At 6 mo after small bowel resection SS content and SS receptors had returned to control values. However, the original increase in SS receptor number was accompanied by a decrease in the ability of SS to inhibit forskolin-stimulated adenylyl cyclase (AC) activity. In addition, the ability of 5'-guanylylimidodiphosphate (a nonhydrolyzable GTP analogue) to inhibit SS receptor binding was decreased in pancreatic acinar membranes from enterectomized rats at 2 wk and 1 mo after jejunoileal resection. These data suggest that there is an abnormality in the integrity of SS receptor binding site-G protein interactions and would explain the decreased inactivation of AC by SS at 2 wk and 1 mo after proximal small bowel resection.

Structural modification of receptor-binding technetium-99m complexes in order to improve brain uptake

1997 ◽  
Vol 24 (3) ◽  
pp. 316-319
Author(s):  
Bernd Johannsen ◽  
Ralf Berger ◽  
Peter Brust ◽  
Hans-Juergen Pietzsch ◽  
Matthias Scheunemann ◽  
...  
Keyword(s):  
Receptor Binding ◽  
Structural Modification ◽  
Brain Uptake ◽  
Technetium 99M

The effect of TGF-β receptor binding peptides on smooth muscle cells

2002 ◽  
Vol 293 (4) ◽  
pp. 1279-1286 ◽  
Author(s):  
Ingrid N. Michon ◽  
Louis C. Penning ◽  
Tom J.M. Molenaar ◽  
Theo J.C. van Berkel ◽  
Erik A.L. Biessen ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Receptor Binding ◽  
Muscle Cells ◽  
Binding Peptides ◽  
Β Receptor
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