Structural Basis for Platelet Antiaggregation by Angiotensin II Type 1 Receptor Antagonist Losartan (DuP-753) via Glycoprotein VI

2010 ◽  
Vol 53 (5) ◽  
pp. 2087-2093 ◽  
Author(s):  
Katsuki Ono ◽  
Hiroshi Ueda ◽  
Yoshitaka Yoshizawa ◽  
Daisuke Akazawa ◽  
Ryuji Tanimura ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Receptor Antagonist ◽  
Structural Basis ◽  
Glycoprotein Vi

Effect of angiotensin II type 1 receptor antagonist on tumor growth and angiogenesis in a xenograft model of human bladder cancer

Human Cell ◽  
2007 ◽  
Vol 20 (1) ◽  
pp. 1-9 ◽  
Author(s):  
Michio KOSUGI ◽  
Akira MIYAJIMA ◽  
Eiji KIKUCHI ◽  
Takeo KOSAKA ◽  
Yutaka HORIGUCHI ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Angiotensin Ii ◽  
Tumor Growth ◽  
Receptor Antagonist ◽  
Xenograft Model ◽  
Human Bladder Cancer ◽  
Human Bladder

Long-term treatment with angiotensin II type 1 receptor antagonist, CV-11974, restores β-catenin mRNA expression in volume-overloaded rabbit hearts

2002 ◽  
Vol 17 (1) ◽  
pp. 36-41 ◽  
Author(s):  
Makoto Itoh ◽  
Y. Takeishi ◽  
Shigekazu Nakada ◽  
Takuya Miyamoto ◽  
Yuichi Tsunoda ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Receptor Antagonist ◽  
Mrna Expression ◽  
Term Treatment ◽  
Long Term Treatment

scholarly journals Effects of Angiotensin II Type 1 Receptor Antagonist, YM358, on Cardiac Hypertrophy and Dysfunction after Myocardial Infarction in Rats

2002 ◽  
Vol 25 (7) ◽  
pp. 857-860 ◽  
Author(s):  
Tomoko Tokioka-Akagi ◽  
Akira Fujimori ◽  
Masayuki Shibasaki ◽  
Yasuko Matsuda-Satoh ◽  
Osamu Inagaki ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Angiotensin Ii ◽  
Cardiac Hypertrophy ◽  
Receptor Antagonist

Angiotensin II Type 1 Receptor Antagonist Suppress Angiogenesis and Growth of Gastric Cancer Xenografts

2007 ◽  
Vol 53 (5) ◽  
pp. 1206-1210 ◽  
Author(s):  
Wei Huang ◽  
Yun-Lin Wu ◽  
Jie Zhong ◽  
Feng-Xiang Jiang ◽  
Xiang-long Tian ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Angiotensin Ii ◽  
Receptor Antagonist

scholarly journals Mitochondrial angiotensin II receptors regulate oxygen consumption in kidney mitochondria from healthy and type 1 diabetic rats

2020 ◽  
Vol 318 (3) ◽  
pp. F683-F688 ◽  
Author(s):  
Malou Friederich-Persson ◽  
Patrik Persson
Keyword(s):  
Nitric Oxide ◽  
Oxygen Consumption ◽  
Angiotensin Ii ◽  
Receptor Antagonist ◽  
Diabetic Rats ◽  
Kidney Cortex ◽  
Ang Ii ◽  
Kidney Mitochondria ◽  
Receptor Inhibition

Exaggerated activation of the renin-angiotensin-aldosterone system (RAAS) is a key feature in diseases such as hypertension, diabetes, and chronic kidney disease. Recently, an intracellular RAAS was demonstrated with angiotensin II (ANG II) type 1 (AT1) and type 2 (AT2) receptors expressed in nuclei and mitochondria. Diabetes is associated with both mitochondrial dysfunction and increased intracellular ANG II concentration in the kidney cortex. The present study investigated the role of ANG II signaling in kidney cortex mitochondria isolated from control and streptozotocin-induced diabetic rats. Mitochondrial oxygen consumption was evaluated after addition of ANG II alone or after preincubation with candesartan (AT1 receptor antagonist), PD-123319 (AT2 receptor antagonist), or the two in combination. ANG II binds to only mitochondrial AT2 receptors in control rats and both AT1 receptors and AT2 receptors in diabetic rats. ANG II decreased oxygen consumption in mitochondria from both control and diabetic rats. ANG II response was reversed to increased oxygen consumption by the nitric oxide synthase inhibitor N-nitro-l-arginine methyl ester. AT1 receptor inhibition did not affect the response to ANG II, whereas AT2 receptor inhibition abolished the response in mitochondria from control rats and reversed the response to increased oxygen consumption through superoxide-induced mitochondrial uncoupling in mitochondria from diabetic rats. ANG II decrease mitochondrial respiration via AT2 receptor-mediated nitric oxide release in both control and diabetic rats. AT1 receptors do not regulate mitochondria function in control rats, whereas ANG II via AT1 receptors increase mitochondria leak respiration in diabetic animals.

scholarly journals Angiotensin II Type 1 Receptor Antagonist Downregulates Nonmuscle Myosin Heavy Chains in Spontaneously Hypertensive Rat Aorta

Hypertension ◽  
1999 ◽  
Vol 33 (4) ◽  
pp. 975-980 ◽  
Author(s):  
Kozo Fujii ◽  
Seiji Umemoto ◽  
Akihisa Fujii ◽  
Takahito Yonezawa ◽  
Toshihiro Sakumura ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Receptor Antagonist ◽  
Spontaneously Hypertensive Rat ◽  
Rat Aorta ◽  
Myosin Heavy Chains ◽  
Nonmuscle Myosin ◽  
Spontaneously Hypertensive ◽  
Heavy Chains ◽  
Hypertensive Rat

scholarly journals Constitutively Active Mutant N111G of Angiotensin II Type 1 (AT1) Receptor Induces Homologous Internalization Through Mediation of AT1-Receptor Antagonist

2009 ◽  
Vol 111 (3) ◽  
pp. 227-234 ◽  
Author(s):  
Mohiuddin Ahmed Bhuiyan ◽  
Murad Hossain ◽  
Shin-ichiro Miura ◽  
Takashi Nakamura ◽  
Masanobu Ozaki ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Receptor Antagonist ◽  
At1 Receptor ◽  
Constitutively Active

Preventive for onset of diastolic heart failure in hypertension -beneficial effects of angiotensin II type 1 receptor antagonist

1998 ◽  
Vol 4 (3) ◽  
pp. 68
Author(s):  
Reiko Doi ◽  
Tohru Masuyama ◽  
Kazuhiro Yamamoto ◽  
Keiko Ono ◽  
Hiroya Kondo ◽  
...  
Keyword(s):  
Heart Failure ◽  
Angiotensin Ii ◽  
Receptor Antagonist ◽  
Diastolic Heart Failure ◽  
Beneficial Effects
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