Synthesis and Structure−Activity Relationships of Azamacrocyclic C-X-C Chemokine Receptor 4 Antagonists: Analogues Containing a Single Azamacrocyclic Ring are Potent Inhibitors of T-Cell Tropic (X4) HIV-1 Replication

2010 ◽  
Vol 53 (3) ◽  
pp. 1250-1260 ◽  
Author(s):  
Gary J. Bridger ◽  
Renato T. Skerlj ◽  
Pedro E. Hernandez-Abad ◽  
David E. Bogucki ◽  
Zhongren Wang ◽  
...  
Keyword(s):  
T Cell ◽  
Chemokine Receptor ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
Chemokine Receptor 4 ◽  
Hiv 1

Synthesis and Structure–Activity Relationships of Indazole Arylsulfonamides as Allosteric CC-Chemokine Receptor 4 (CCR4) Antagonists

2013 ◽  
Vol 56 (5) ◽  
pp. 1946-1960 ◽  
Author(s):  
Panayiotis A. Procopiou ◽  
John W. Barrett ◽  
Nicholas P. Barton ◽  
Malcolm Begg ◽  
David Clapham ◽  
...  
Keyword(s):  
Chemokine Receptor ◽  
Cc Chemokine ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
Chemokine Receptor 4

Synthesis and Structure−Activity Relationships of Phenylenebis(methylene)- Linked Bis-azamacrocycles That Inhibit HIV-1 and HIV-2 Replication by Antagonism of the Chemokine Receptor CXCR4

1999 ◽  
Vol 42 (19) ◽  
pp. 3971-3981 ◽  
Author(s):  
Gary J. Bridger ◽  
Renato T. Skerlj ◽  
Sreenivasan Padmanabhan ◽  
Stephen A. Martellucci ◽  
Geoffrey W. Henson ◽  
...  
Keyword(s):  
Chemokine Receptor ◽  
Structure Activity Relationships ◽  
Chemokine Receptor Cxcr4 ◽  
Structure Activity ◽  
Hiv 1

IL-8 responsiveness defines a subset of CD8 T cells poised to kill

Blood ◽  
2004 ◽  
Vol 104 (12) ◽  
pp. 3463-3471 ◽  
Author(s):  
Christoph Hess ◽  
Terry K. Means ◽  
Patrick Autissier ◽  
Tonia Woodberry ◽  
Marcus Altfeld ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Chemokine Receptor ◽  
Cd8 T Cells ◽  
Molecular Mechanisms ◽  
Cell Subset ◽  
Cd8 T Cell ◽  
Effector Memory ◽  
Immune System Activation ◽  
Hiv 1

CD8 T cells play a key role in host defense against intracellular pathogens. Efficient migration of these cells into sites of infection is therefore intimately linked to their effector function. The molecular mechanisms that control CD8 T-cell trafficking into sites of infection and inflammation are not well understood, but the chemokine/chemokine receptor system is thought to orchestrate this process. Here we systematically examined the chemokine receptor profile expressed on human CD8 T cells. Surprisingly, we found that CXC chemokine receptor 1 (CXCR1), the predominant neutrophil chemokine receptor, defined a novel interleukin-8/CXC ligand 8 (IL-8/CXCL8)–responsive CD8 T-cell subset that was enriched in perforin, granzyme B, and interferon-γ (IFNγ), and had high cytotoxic potential. CXCR1 expression was down-regulated by antigen stimulation both in vitro and in vivo, suggesting antigen-dependent shaping of the migratory characteristics of CD8 T cells. On virus-specific CD8 T cells from persons with a history of Epstein-Barr virus (EBV) and influenza infection, CXCR1 expression was restricted to terminally differentiated effector memory cells. In HIV-1 infection, CXCR1-expressing HIV-1–specific CD8 T cells were present only in persons who were able to control HIV-1 replication during structured treatment interruptions. Thus, CXCR1 identifies a subset of CD8 T cells poised for immediate cytotoxicity and early recruitment into sites of innate immune system activation.

Structure−Activity Relationships of 2‘-Fluoro-2‘,3‘-unsaturatedd-Nucleosides as Anti-HIV-1 Agents

2002 ◽  
Vol 45 (6) ◽  
pp. 1313-1320 ◽  
Author(s):  
Kyeong Lee ◽  
Yongseok Choi ◽  
Giuseppe Gumina ◽  
Wen Zhou ◽  
Raymond F. Schinazi ◽  
...  
Keyword(s):  
Structure Activity Relationships ◽  
Structure Activity ◽  
Anti Hiv ◽  
Hiv 1
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