Design, Synthesis, and Structure−Activity Relationships of AminopyridineN-Oxides, a Novel Scaffold for the Potent and Selective Inhibition of p38 Mitogen Activated Protein Kinase

2009 ◽  
Vol 52 (17) ◽  
pp. 5531-5545 ◽  
Author(s):  
Wenceslao Lumeras ◽  
Francisco Caturla ◽  
Laura Vidal ◽  
Cristina Esteve ◽  
Cristina Balagué ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Selective Inhibition ◽  
Mitogen Activated Protein Kinase ◽  
Design Synthesis ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
Mitogen Activated Protein ◽  
Novel Scaffold

Insight into the selective inhibition of JNK family members through structure-based drug design

MedChemComm ◽  
2016 ◽  
Vol 7 (4) ◽  
pp. 686-692
Author(s):  
A. Messoussi ◽  
G. Chevé ◽  
K. Bougrin ◽  
A. Yasri
Keyword(s):  
Protein Kinase ◽  
Drug Design ◽  
Neurodegenerative Disorders ◽  
Family Members ◽  
Selective Inhibition ◽  
Mitogen Activated Protein Kinase ◽  
Biological Processes ◽  
Structure Based Drug Design ◽  
Mitogen Activated Protein ◽  
Insight Into

The c-Jun N-terminal kinase (JNK) family, which comprises JNK1, JNK2 and JNK3, belongs to the mitogen-activated protein kinase (MAPK) superfamily, whose members regulate myriad biological processes, including those implicated in tumorigenesis and neurodegenerative disorders.

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