Design, Synthesis, and Biological Evaluation of (2R,αS)-3,4-Dihydro-2-[3-(1,1,2,2-tetrafluoroethoxy)phenyl]-5-[3-(trifluoromethoxy)-phenyl]-α-(trifluoromethyl)-1(2H)-quinolineethanol as Potent and Orally Active Cholesteryl Ester Transfer Protein Inhibitor

Gee-Hong Kuo; Thomas Rano; Patricia Pelton; Keith T. Demarest; Alan C. Gibbs; William V. Murray; Bruce P. Damiano; Margery A. Connelly

doi:10.1021/jm801319d

Design, Synthesis, and Biological Evaluation of (2R,αS)-3,4-Dihydro-2-[3-(1,1,2,2-tetrafluoroethoxy)phenyl]-5-[3-(trifluoromethoxy)-phenyl]-α-(trifluoromethyl)-1(2H)-quinolineethanol as Potent and Orally Active Cholesteryl Ester Transfer Protein Inhibitor

Journal of Medicinal Chemistry ◽

10.1021/jm801319d ◽

2009 ◽

Vol 52 (6) ◽

pp. 1768-1772 ◽

Cited By ~ 31

Author(s):

Gee-Hong Kuo ◽

Thomas Rano ◽

Patricia Pelton ◽

Keith T. Demarest ◽

Alan C. Gibbs ◽

...

Keyword(s):

Cholesteryl Ester ◽

Cholesteryl Ester Transfer Protein ◽

Biological Evaluation ◽

Protein Inhibitor ◽

Design Synthesis ◽

Transfer Protein ◽

Orally Active ◽

Synthesis And Biological Evaluation

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Design, synthesis and biological evaluation of N,N-3-phenyl-3-benzylaminopropanamide derivatives as novel cholesteryl ester transfer protein inhibitor

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2015.12.010 ◽

2016 ◽

Vol 24 (8) ◽

pp. 1589-1597 ◽

Cited By ~ 6

Author(s):

Dongmei Zhao ◽

Honglei Xie ◽

Changlin Bai ◽

Chunchi Liu ◽

Chenzhou Hao ◽

...

Keyword(s):

Cholesteryl Ester ◽

Cholesteryl Ester Transfer Protein ◽

Biological Evaluation ◽

Protein Inhibitor ◽

Design Synthesis ◽

Transfer Protein ◽

Synthesis And Biological Evaluation

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Design, Synthesis, and Biological Evaluation of Benzylamino-Methanone Based Cholesteryl Ester Transfer Protein Inhibitors

Molecules ◽

10.3390/molecules15085721 ◽

2010 ◽

Vol 15 (8) ◽

pp. 5721-5733 ◽

Cited By ~ 7

Author(s):

Ghassan Abu Sheikha ◽

Reema Abu Khalaf ◽

Areej Melhem ◽

Ghadeer Albadawi

Keyword(s):

Cholesteryl Ester ◽

Cholesteryl Ester Transfer Protein ◽

Biological Evaluation ◽

Protein Inhibitors ◽

Design Synthesis ◽

Transfer Protein ◽

Synthesis And Biological Evaluation

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Design, synthesis and biological evaluation of novel cholesteryl ester transfer protein inhibitors bearing a cycloalkene scaffold

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2016.07.065 ◽

2016 ◽

Vol 123 ◽

pp. 419-430 ◽

Cited By ~ 2

Author(s):

Chunchi Liu ◽

Changqun Luo ◽

Lijuan Hao ◽

Qiong Wu ◽

Honglei Xie ◽

...

Keyword(s):

Cholesteryl Ester ◽

Cholesteryl Ester Transfer Protein ◽

Biological Evaluation ◽

Protein Inhibitors ◽

Design Synthesis ◽

Transfer Protein ◽

Synthesis And Biological Evaluation

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Pharmacophore-based design, synthesis, and biological evaluation of novel 3-((3,4-dichlorophenyl)(4-substituted benzyl)amino) propanamides as cholesteryl ester transfer protein (CETP) inhibitors

Chinese Chemical Letters ◽

10.1016/j.cclet.2013.11.033 ◽

2014 ◽

Vol 25 (2) ◽

pp. 299-304 ◽

Cited By ~ 4

Author(s):

Dong-Mei Zhao ◽

Wen-Yan Li ◽

Yu-Fang Shi ◽

Xu-Qiong Xiong ◽

Shuai Song ◽

...

Keyword(s):

Cholesteryl Ester ◽

Cholesteryl Ester Transfer Protein ◽

Biological Evaluation ◽

Design Synthesis ◽

Transfer Protein ◽

Cetp Inhibitors ◽

Synthesis And Biological Evaluation

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Design, Synthesis and Biological Evaluation of N,N-Substituted Amine Derivatives as Cholesteryl Ester Transfer Protein Inhibitors

Molecules ◽

10.3390/molecules22101658 ◽

2017 ◽

Vol 22 (10) ◽

pp. 1658 ◽

Cited By ~ 1

Author(s):

Xinran Wang ◽

Lijuan Hao ◽

Xuanqi Xu ◽

Wei Li ◽

Chunchi Liu ◽

...

Keyword(s):

Cholesteryl Ester ◽

Cholesteryl Ester Transfer Protein ◽

Biological Evaluation ◽

Protein Inhibitors ◽

Design Synthesis ◽

Transfer Protein ◽

Synthesis And Biological Evaluation

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Faculty Opinions recommendation of Effect of the cholesteryl ester transfer protein inhibitor, anacetrapib, on lipoproteins in patients with dyslipidaemia and on 24-h ambulatory blood pressure in healthy individuals: two double-blind, randomised placebo-controlled phase I studies.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1097533.553610 ◽

2007 ◽

Author(s):

Rhian Touyz

Keyword(s):

Blood Pressure ◽

Phase I ◽

Cholesteryl Ester ◽

Cholesteryl Ester Transfer Protein ◽

Ambulatory Blood Pressure ◽

Healthy Individuals ◽

Protein Inhibitor ◽

Double Blind ◽

Phase I Studies ◽

Transfer Protein

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Faculty Opinions recommendation of Efficacy and safety of the cholesteryl ester transfer protein inhibitor anacetrapib as monotherapy and coadministered with atorvastatin in dyslipidemic patients.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1148081.605196 ◽

2009 ◽

Author(s):

Anders Olsson

Keyword(s):

Cholesteryl Ester ◽

Cholesteryl Ester Transfer Protein ◽

Efficacy And Safety ◽

Protein Inhibitor ◽

Transfer Protein

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Efficacy and safety after cessation of treatment with the cholesteryl ester transfer protein inhibitor anacetrapib (MK-0859) in patients with primary hypercholesterolemia or mixed hyperlipidemia

American Heart Journal ◽

10.1016/j.ahj.2011.07.010 ◽

2011 ◽

Vol 162 (4) ◽

pp. 708-716 ◽

Cited By ~ 22

Author(s):

Hayes M. Dansky ◽

Daniel Bloomfield ◽

Patrice Gibbons ◽

Sherry Liu ◽

Christine McCrary Sisk ◽

...

Keyword(s):

Cholesteryl Ester ◽

Cholesteryl Ester Transfer Protein ◽

Efficacy And Safety ◽

Protein Inhibitor ◽

Primary Hypercholesterolemia ◽

Transfer Protein ◽

Mixed Hyperlipidemia ◽

Cessation Of Treatment

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Cholesteryl Ester Transfer Protein Inhibitor Torcetrapib and Off-Target Toxicity

Circulation ◽

10.1161/circulationaha.108.772665 ◽

2008 ◽

Vol 118 (24) ◽

pp. 2515-2522 ◽

Cited By ~ 115

Author(s):

Menno Vergeer ◽

Michiel L. Bots ◽

Sander I. van Leuven ◽

Dick C. Basart ◽

Eric J. Sijbrands ◽

...

Keyword(s):

Cholesteryl Ester ◽

Cholesteryl Ester Transfer Protein ◽

Protein Inhibitor ◽

Transfer Protein

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Asymmetric Synthesis of the Cholesteryl Ester Transfer Protein Inhibitor Torcetrapib

Organic Process Research & Development ◽

10.1021/op060013i ◽

2006 ◽

Vol 10 (3) ◽

pp. 472-480 ◽

Cited By ~ 50

Author(s):

David B. Damon ◽

Robert W. Dugger ◽

Stephen E. Hubbs ◽

Jill M. Scott ◽

Robert W. Scott

Keyword(s):

Cholesteryl Ester ◽

Asymmetric Synthesis ◽

Cholesteryl Ester Transfer Protein ◽

Protein Inhibitor ◽

Transfer Protein

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