Berberine Analogues as a Novel Class of the Low-Density-Lipoprotein Receptor Up-Regulators: Synthesis, Structure−Activity Relationships, and Cholesterol-Lowering Efficacy

Ying-Hong Li; Peng Yang; Wei-Jia Kong; Yan-Xiang Wang; Chang-Qin Hu; Zeng-Yan Zuo; Yue-Ming Wang; Hong Gao; Li-Mei Gao; Yan-Chun Feng; Na-Na Du; Ying Liu; Dan-Qing Song; Jian-Dong Jiang

doi:10.1021/jm801157z

Berberine Analogues as a Novel Class of the Low-Density-Lipoprotein Receptor Up-Regulators: Synthesis, Structure−Activity Relationships, and Cholesterol-Lowering Efficacy

Journal of Medicinal Chemistry ◽

10.1021/jm801157z ◽

2009 ◽

Vol 52 (2) ◽

pp. 492-501 ◽

Cited By ~ 64

Author(s):

Ying-Hong Li ◽

Peng Yang ◽

Wei-Jia Kong ◽

Yan-Xiang Wang ◽

Chang-Qin Hu ◽

...

Keyword(s):

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Low Density ◽

Lipoprotein Receptor ◽

Low Density Lipoprotein Receptor ◽

Cholesterol Lowering ◽

Structure Activity Relationships ◽

Structure Activity ◽

Density Lipoprotein Receptor

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Synthesis and structure–activity relationships of berberine analogues as a novel class of low-density-lipoprotein receptor up-regulators

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2008.07.005 ◽

2008 ◽

Vol 18 (16) ◽

pp. 4675-4677 ◽

Cited By ~ 49

Author(s):

Peng Yang ◽

Dan-Qing Song ◽

Ying-Hong Li ◽

Wei-Jia Kong ◽

Yan-Xiang Wang ◽

...

Keyword(s):

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Low Density ◽

Lipoprotein Receptor ◽

Low Density Lipoprotein Receptor ◽

Structure Activity Relationships ◽

Structure Activity ◽

Density Lipoprotein Receptor

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ChemInform Abstract: Synthesis and Structure-Activity Relationships of Berberine Analogues as a Novel Class of Low-Density-Lipoprotein Receptor Up-Regulators.

ChemInform ◽

10.1002/chin.200902202 ◽

2009 ◽

Vol 40 (2) ◽

Author(s):

Peng Yang ◽

Dan-Qing Song ◽

Ying-Hong Li ◽

Wei-Jia Kong ◽

Yan-Xiang Wang ◽

...

Keyword(s):

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Low Density ◽

Lipoprotein Receptor ◽

Low Density Lipoprotein Receptor ◽

Structure Activity Relationships ◽

Structure Activity ◽

Density Lipoprotein Receptor

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Low-density lipoprotein receptor genotype-dependent response to cholesterol lowering by combined pravastatin and cholestyramine in familial hypercholesterolemia

The American Journal of Cardiology ◽

10.1016/s0002-9149(98)00230-6 ◽

1998 ◽

Vol 82 (1) ◽

pp. 113-A8 ◽

Cited By ~ 23

Author(s):

Kouji Kajinami ◽

Kunimasa Yagi ◽

Toshinori Higashikata ◽

Akihiro Inazu ◽

Junji Koizumi ◽

...

Keyword(s):

Familial Hypercholesterolemia ◽

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Low Density ◽

Lipoprotein Receptor ◽

Low Density Lipoprotein Receptor ◽

Cholesterol Lowering ◽

Density Lipoprotein Receptor

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Cholesterol lowering in low density lipoprotein receptor knockout mice overexpressing apolipoprotein E.

Journal of Clinical Investigation ◽

10.1172/jci1124 ◽

1998 ◽

Vol 102 (2) ◽

pp. 386-394 ◽

Cited By ~ 15

Author(s):

J Osuga ◽

M Yonemoto ◽

N Yamada ◽

H Shimano ◽

H Yagyu ◽

...

Keyword(s):

Apolipoprotein E ◽

Knockout Mice ◽

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Low Density ◽

Lipoprotein Receptor ◽

Low Density Lipoprotein Receptor ◽

Cholesterol Lowering ◽

Density Lipoprotein Receptor

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518-P: Involvement of Low-Density Lipoprotein Receptor-Related Protein 5 in Chronic Kidney Diseases via Modulation of TGF-β-Smad2/3 Signaling

Diabetes ◽

10.2337/db19-518-p ◽

2019 ◽

Vol 68 (Supplement 1) ◽

pp. 518-P

Author(s):

XUEMIN HE ◽

RUI CHENG ◽

CHAO HUANG ◽

YANMING CHEN ◽

JIAN-XING MA

Keyword(s):

Kidney Diseases ◽

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Low Density ◽

Lipoprotein Receptor ◽

Related Protein ◽

Low Density Lipoprotein Receptor ◽

Chronic Kidney Diseases ◽

Density Lipoprotein Receptor ◽

Lipoprotein Receptor Related Protein

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Phenotypic presentation of the FH-Cincinnati type 5 low density lipoprotein receptor mutation

Scandinavian Journal of Clinical and Laboratory Investigation ◽

10.3109/00365519609088591 ◽

1996 ◽

Vol 56 (1) ◽

pp. 75-85 ◽

Cited By ~ 2

Author(s):

H. Nissen ◽

A. B. Hansen ◽

P. Guldberg ◽

N. E. Petersen ◽

M. L. Larsen ◽

...

Keyword(s):

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Low Density ◽

Lipoprotein Receptor ◽

Low Density Lipoprotein Receptor ◽

Density Lipoprotein Receptor

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Faculty Opinions recommendation of Low-density lipoprotein receptor-related protein 5 governs Wnt-mediated osteoarthritic cartilage destruction.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718258241.793492848 ◽

2014 ◽

Author(s):

Yefu Li ◽

Lin Xu

Keyword(s):

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Cartilage Destruction ◽

Low Density ◽

Lipoprotein Receptor ◽

Related Protein ◽

Low Density Lipoprotein Receptor ◽

Osteoarthritic Cartilage ◽

Density Lipoprotein Receptor ◽

Lipoprotein Receptor Related Protein

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Faculty Opinions recommendation of Autoantibodies to low-density lipoprotein receptor-related protein 4 in myasthenia gravis.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.9232956.9826054 ◽

2011 ◽

Author(s):

Steven Burden

Keyword(s):

Myasthenia Gravis ◽

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Low Density ◽

Lipoprotein Receptor ◽

Related Protein ◽

Low Density Lipoprotein Receptor ◽

Density Lipoprotein Receptor ◽

Lipoprotein Receptor Related Protein

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Hypoxia Could Induce Endoplasmic-Reticulum Stress by Regulating the Expression of β-Catenin Via Low-Density Lipoprotein Receptor-Related Protein 6 Pathway

SSRN Electronic Journal ◽

10.2139/ssrn.3289784 ◽

2018 ◽

Author(s):

Yanlei Ma ◽

Ting Liu ◽

Xiaomei Li ◽

Chao Lei ◽

Jinsheng Weng ◽

...

Keyword(s):

Endoplasmic Reticulum ◽

Endoplasmic Reticulum Stress ◽

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Low Density ◽

Lipoprotein Receptor ◽

Related Protein ◽

Low Density Lipoprotein Receptor ◽

Density Lipoprotein Receptor ◽

Lipoprotein Receptor Related Protein

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NPXY, a sequence often found in cytoplasmic tails, is required for coated pit-mediated internalization of the low density lipoprotein receptor.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(19)39742-x ◽

1990 ◽

Vol 265 (6) ◽

pp. 3116-3123 ◽

Cited By ~ 4

Author(s):

W J Chen ◽

J L Goldstein ◽

M S Brown

Keyword(s):

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Low Density ◽

Lipoprotein Receptor ◽

Low Density Lipoprotein Receptor ◽

Cytoplasmic Tails ◽

Density Lipoprotein Receptor

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