Potent, Orally Bioavailable Delta Opioid Receptor Agonists for the Treatment of Pain: Discovery ofN,N-Diethyl-4-(5-hydroxyspiro[chromene-2,4′-piperidine]-4-yl)benzamide (ADL5859)

2008 ◽  
Vol 51 (19) ◽  
pp. 5893-5896 ◽  
Author(s):  
Bertrand Le Bourdonnec ◽  
Rolf T. Windh ◽  
Christopher W. Ajello ◽  
Lara K. Leister ◽  
Minghua Gu ◽  
...  
Keyword(s):  
Opioid Receptor ◽  
Delta Opioid Receptor ◽  
Receptor Agonists ◽  
Orally Bioavailable ◽  
Opioid Receptor Agonists

Chemical Characterization and in vitro Metabolism of a Novel Class of Delta Opioid Receptor Agonists, Analogs of SNC-80

2019 ◽  
Vol 4 (7) ◽  
pp. 2109-2115
Author(s):  
Elisabetta Maria Usai ◽  
Ilaria Manca ◽  
Francesca Pettinau ◽  
Antonio Mastino ◽  
Barbara Pittau
Keyword(s):  
Opioid Receptor ◽  
Chemical Characterization ◽  
In Vitro Metabolism ◽  
Delta Opioid Receptor ◽  
Receptor Agonists ◽  
Opioid Receptor Agonists

N-Guanidyl and C-Tetrazole Leu-Enkephalin Derivatives: Efficient Mu and Delta Opioid Receptor Agonists with Improved Pharmacological Properties

2019 ◽  
Vol 10 (3) ◽  
pp. 1615-1626 ◽  
Author(s):  
Jean-Louis Beaudeau ◽  
Véronique Blais ◽  
Brian J. Holleran ◽  
Alexandre Bergeron ◽  
Graciela Piñeyro ◽  
...  
Keyword(s):  
Opioid Receptor ◽  
Delta Opioid Receptor ◽  
Pharmacological Properties ◽  
Receptor Agonists ◽  
Opioid Receptor Agonists

scholarly journals Peptidic delta opioid receptor agonists produce antidepressant-like effects in the forced swim test and regulate BDNF mRNA expression in rats

2006 ◽  
Vol 1069 (1) ◽  
pp. 172-181 ◽  
Author(s):  
Mary M. Torregrossa ◽  
Emily M. Jutkiewicz ◽  
Henry I. Mosberg ◽  
Gianfranco Balboni ◽  
Stanley J. Watson ◽  
...  
Keyword(s):  
Mrna Expression ◽  
Opioid Receptor ◽  
Forced Swim Test ◽  
Delta Opioid Receptor ◽  
Bdnf Mrna ◽  
Receptor Agonists ◽  
Swim Test ◽  
Forced Swim ◽  
Opioid Receptor Agonists

Alleviating pain with delta opioid receptor agonists: evidence from experimental models

2020 ◽  
Vol 127 (4) ◽  
pp. 661-672 ◽  
Author(s):  
Sophie Berthiaume ◽  
Khaled Abdallah ◽  
Véronique Blais ◽  
Louis Gendron
Keyword(s):  
Opioid Receptor ◽  
Experimental Models ◽  
Delta Opioid Receptor ◽  
Receptor Agonists ◽  
Opioid Receptor Agonists

Design and synthesis of novel delta opioid receptor agonists and their pharmacologies

2009 ◽  
Vol 19 (10) ◽  
pp. 2792-2795 ◽  
Author(s):  
Hiroshi Nagase ◽  
Yumiko Osa ◽  
Toru Nemoto ◽  
Hideaki Fujii ◽  
Masayuki Imai ◽  
...  
Keyword(s):  
Opioid Receptor ◽  
Delta Opioid Receptor ◽  
Receptor Agonists ◽  
Design And Synthesis ◽  
Opioid Receptor Agonists
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