2-Phenyl-imidazo[1,2-a]pyridine Compounds Containing Hydrophilic Groups as Potent and Selective Ligands for Peripheral Benzodiazepine Receptors: Synthesis, Binding Affinity and Electrophysiological Studies

2008 ◽  
Vol 51 (21) ◽  
pp. 6876-6888 ◽  
Author(s):  
Nunzio Denora ◽  
Valentino Laquintana ◽  
Maria Giuseppina Pisu ◽  
Riccardo Dore ◽  
Luca Murru ◽  
...  
Keyword(s):  
Binding Affinity ◽  
Benzodiazepine Receptors ◽  
Peripheral Benzodiazepine Receptors ◽  
Selective Ligands ◽  
Electrophysiological Studies

Synthesis of substituted [123I]imidazo[1,2-α]pyridines as potential probes for the study of the peripheral benzodiazepine receptors using SPECT

2000 ◽  
Vol 88 (3-4) ◽  
Author(s):  
Andrew Katsifis ◽  
F. Mattner ◽  
B. Dikic ◽  
V. Papazian
Keyword(s):  
Benzodiazepine Receptors ◽  
High Affinity ◽  
Peripheral Benzodiazepine Receptors ◽  
Selective Ligands

The imidazo[1,2-α]pyridines [N,N´-dimethyl-6-chloro-(4´zf-iodophenyl)imidazo[1,2-α]pyridine-3-acetamide 1, [N,N´l-6-chloro-(4´-iodophenyl)imidazo[1,2-α]pyridine-3-acetamide 2, and [N-methyl-6-chloro-(4´-iodophenyl)imidazo[1,2-α]pyridine-3-acetamide 3, are high affinity and selective ligands for the Peripheral Benzodiazepine Receptors (PBR). The [

In vivo imaging of brain lesions with [11C]CLINME, a new PET radioligand of peripheral benzodiazepine receptors

Glia ◽  
2007 ◽  
Vol 55 (14) ◽  
pp. 1459-1468 ◽  
Author(s):  
Hervé Boutin ◽  
Fabien Chauveau ◽  
Cyrille Thominiaux ◽  
Bertrand Kuhnast ◽  
Marie-Claude Grégoire ◽  
...  
Keyword(s):  
In Vivo Imaging ◽  
Benzodiazepine Receptors ◽  
Brain Lesions ◽  
Peripheral Benzodiazepine Receptors

Peripheral benzodiazepine receptors in suicide attempters

1997 ◽  
Vol 42 (1) ◽  
pp. 23S
Author(s):  
D. Marazziti ◽  
L. Palego ◽  
A. Rossi ◽  
L. Conti
Keyword(s):  
Benzodiazepine Receptors ◽  
Suicide Attempters ◽  
Peripheral Benzodiazepine Receptors

scholarly journals In Vivo Imaging of Peripheral Benzodiazepine Receptors in Mouse Lungs: A Biomarker of Inflammation

2005 ◽  
Vol 4 (4) ◽  
pp. 7290.2005.05133 ◽  
Author(s):  
Matthew J. Hardwick ◽  
Ming-Kai Chen ◽  
Kwamena Baidoo ◽  
Martin G. Pomper ◽  
Tomás R. Guilarte
Keyword(s):  
In Vivo Imaging ◽  
Ex Vivo ◽  
Inflammatory Diseases ◽  
Imaging Techniques ◽  
Benzodiazepine Receptors ◽  
Small Animal ◽  
Small Animal Pet ◽  
Planar Imaging ◽  
Peripheral Benzodiazepine Receptors

The ability to visualize the immune response with radioligands targeted to immune cells will enhance our understanding of cellular responses in inflammatory diseases. Peripheral benzodiazepine receptors (PBR) are present in monocytes and neutrophils as well as in lung tissue. We used lipopolysaccharide (LPS) as a model of inflammation to assess whether the PBR could be used as a noninvasive marker of inflammation in the lungs. Planar imaging of mice administrated 10 or 30 mg/kg LPS showed increased [123I]-( R)-PK11195 radioactivity in the thorax 2 days after LPS treatment relative to control. Following imaging, lungs from control and LPS-treated mice were harvested for ex vivo gamma counting and showed significantly increased radioactivity above control levels. The specificity of the PBR response was determined using a blocking dose of nonradioactive PK11195 given 30 min prior to radiotracer injection. Static planar images of the thorax of nonradioactive PK11195 pretreated animals showed a significantly lower level of radiotracer accumulation in control and in LPS-treated animals ( p < .05). These data show that LPS induces specific increases in PBR ligand binding in the lungs. We also used in vivo small-animal PET studies to demonstrate increased [11C]-( R)-PK11195 accumulation in the lungs of LPS-treated mice. This study suggests that measuring PBR expression using in vivo imaging techniques may be a useful biomarker to image lung inflammation.

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