Investigations on the 4-Quinolone-3-carboxylic Acid Motif. 2. Synthesis and Structure−Activity Relationship of Potent and Selective Cannabinoid-2 Receptor Agonists Endowed with Analgesic Activity in Vivo⊥

2008 ◽  
Vol 51 (16) ◽  
pp. 5075-5084 ◽  
Author(s):  
Serena Pasquini ◽  
Lorenzo Botta ◽  
Teresa Semeraro ◽  
Claudia Mugnaini ◽  
Alessia Ligresti ◽  
...  
Keyword(s):  
Carboxylic Acid ◽  
Analgesic Activity ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Receptor Agonists ◽  
Structure Activity ◽  
Relationship Of

Synthesis of Hippospongic Acid A Analogues Designed for Investigating the Structure-Activity Relationship of its Biological Activity

2000 ◽  
Vol 53 (12) ◽  
pp. 909 ◽  
Author(s):  
Yoshikazu Hiraga ◽  
Mariko Ago ◽  
Munetaka Tokumasu ◽  
Ken Kaku ◽  
Katsuo Ohkata
Keyword(s):  
Biological Activity ◽  
Carboxylic Acid ◽  
Sea Urchin ◽  
Essential Feature ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Acid Moiety ◽  
Sea Urchin Embryos ◽  
Structure Activity ◽  
Relationship Of

Analogues of hippospongic acid A, which inhibit the gastrulation of sea urchin embryos, were synthesized. From a study on structure—activity relationships, the conjugated carboxylic acid moiety was found to be an essential feature for biological activity.

scholarly journals Antifungal Spectrum, In Vivo Efficacy, and Structure–Activity Relationship of Ilicicolin H

2012 ◽  
Vol 3 (10) ◽  
pp. 814-817 ◽  
Author(s):  
Sheo B. Singh ◽  
Weiguo Liu ◽  
Xiaohua Li ◽  
Tom Chen ◽  
Ali Shafiee ◽  
...  
Keyword(s):  
Structure Activity Relationship ◽  
Activity Relationship ◽  
In Vivo Efficacy ◽  
Structure Activity ◽  
Relationship Of

Discovery and Structure−Activity Relationship of Antagonists of B-Cell Lymphoma 2 Family Proteins with Chemopotentiation Activity in Vitro and in Vivo

2006 ◽  
Vol 49 (3) ◽  
pp. 1165-1181 ◽  
Author(s):  
Michael D. Wendt ◽  
Wang Shen ◽  
Aaron Kunzer ◽  
William J. McClellan ◽  
Milan Bruncko ◽  
...  
Keyword(s):  
B Cell ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Structure Activity ◽  
Relationship Of
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