Investigations on the 4-Quinolone-3-carboxylic Acid Motif. 1. Synthesis and Structure−Activity Relationship of a Class of Human Immunodeficiency Virus type 1 Integrase Inhibitors†

Serena Pasquini; Claudia Mugnaini; Cristina Tintori; Maurizio Botta; Alejandro Trejos; Riina K. Arvela; Mats Larhed; Myriam Witvrouw; Martine Michiels; Frauke Christ; Zeger Debyser; Federico Corelli

doi:10.1021/jm8003784

Investigations on the 4-Quinolone-3-carboxylic Acid Motif. 1. Synthesis and Structure−Activity Relationship of a Class of Human Immunodeficiency Virus type 1 Integrase Inhibitors†

Journal of Medicinal Chemistry ◽

10.1021/jm8003784 ◽

2008 ◽

Vol 51 (16) ◽

pp. 5125-5129 ◽

Cited By ~ 109

Author(s):

Serena Pasquini ◽

Claudia Mugnaini ◽

Cristina Tintori ◽

Maurizio Botta ◽

Alejandro Trejos ◽

...

Keyword(s):

Human Immunodeficiency Virus ◽

Carboxylic Acid ◽

Human Immunodeficiency Virus Type ◽

Virus Type ◽

Activity Relationship ◽

Integrase Inhibitors ◽

Structure Activity ◽

Immunodeficiency Virus ◽

Relationship Of

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ChemInform Abstract: Preparation and Structure-Activity Relationship of Novel P1/P1′- Substituted Cyclic Urea-Based Human Immunodeficiency Virus Type-1 Protease Inhibitors.

ChemInform ◽

10.1002/chin.199637224 ◽

2010 ◽

Vol 27 (37) ◽

pp. no-no

Author(s):

D. A. NUGIEL ◽

K. JACOBS ◽

T. WORLEY ◽

M. PATEL ◽

R. F. III KALTENBACH ◽

...

Keyword(s):

Human Immunodeficiency Virus ◽

Protease Inhibitors ◽

Human Immunodeficiency Virus Type ◽

Virus Type ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Structure Activity ◽

Immunodeficiency Virus ◽

Relationship Of

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Studies of Human Immunodeficiency Virus Type 1 (HIV-1) Protease Inhibitors. III. Structure-Activity Relationship of HIV-1 Protease Inhibitors Containing Cyclohexylalanylalanine Hydroxyethylene Dipeptide lsostere.

Chemical and Pharmaceutical Bulletin ◽

10.1248/cpb.42.534 ◽

1994 ◽

Vol 42 (3) ◽

pp. 534-540 ◽

Cited By ~ 5

Author(s):

Mitsuya SAKURAI ◽

Susumu HIGASHIDA ◽

Machiko SUGANO ◽

Hiroshi HANDA ◽

Tomoaki KOMAI ◽

...

Keyword(s):

Human Immunodeficiency Virus ◽

Protease Inhibitors ◽

Human Immunodeficiency Virus Type ◽

Virus Type ◽

Activity Relationship ◽

Structure Activity ◽

Immunodeficiency Virus ◽

Relationship Of ◽

Hiv 1

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Preparation and Structure−Activity Relationship of Novel P1/P1‘-Substituted Cyclic Urea-Based Human Immunodeficiency Virus Type-1 Protease Inhibitors

Journal of Medicinal Chemistry ◽

10.1021/jm960083n ◽

1996 ◽

Vol 39 (11) ◽

pp. 2156-2169 ◽

Cited By ~ 67

Author(s):

David A. Nugiel ◽

Kim Jacobs ◽

Tabitha Worley ◽

Mona Patel ◽

Robert F. Kaltenbach ◽

...

Keyword(s):

Human Immunodeficiency Virus ◽

Protease Inhibitors ◽

Human Immunodeficiency Virus Type ◽

Virus Type ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Structure Activity ◽

Immunodeficiency Virus ◽

Relationship Of

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Structure-activity relationship studies for various oxathiin carboxanilide derivatives modified in the oxathiin moiety against wild-type and mutant human immunodeficiency virus type 1 strains

Antiviral Research ◽

10.1016/0166-3542(95)94763-r ◽

1995 ◽

Vol 26 (3) ◽

pp. A261

Author(s):

J. Balzarini ◽

W.G. Brouwer ◽

D.C. Dao ◽

E.E. Felauer ◽

W.A. Harrison ◽

...

Keyword(s):

Human Immunodeficiency Virus ◽

Human Immunodeficiency Virus Type ◽

Virus Type ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Wild Type ◽

Structure Activity ◽

Immunodeficiency Virus

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Structure-activity relationships of fluorinated nucleoside analogs and their synergistic effect in combination with phosphonoformate against human immunodeficiency virus type 1.

Antimicrobial Agents and Chemotherapy ◽

10.1128/aac.33.12.2083 ◽

1989 ◽

Vol 33 (12) ◽

pp. 2083-2088 ◽

Cited By ~ 42

Author(s):

R Koshida ◽

S Cox ◽

J Harmenberg ◽

G Gilljam ◽

B Wahren

Keyword(s):

Human Immunodeficiency Virus ◽

Synergistic Effect ◽

Human Immunodeficiency Virus Type ◽

Virus Type ◽

Nucleoside Analogs ◽

Structure Activity Relationships ◽

Structure Activity ◽

Immunodeficiency Virus

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Structure-activity relationships of polybiguanides with activity against human immunodeficiency virus type 1

Biomedicine & Pharmacotherapy ◽

10.1016/j.biopha.2010.10.001 ◽

2010 ◽

Vol 64 (10) ◽

pp. 723-732 ◽

Cited By ~ 13

Author(s):

Shendra R. Passic ◽

Mary Lee Ferguson ◽

Bradley J. Catalone ◽

Tina Kish-Catalone ◽

Vladyslav Kholodovych ◽

...

Keyword(s):

Human Immunodeficiency Virus ◽

Human Immunodeficiency Virus Type ◽

Virus Type ◽

Structure Activity Relationships ◽

Structure Activity ◽

Immunodeficiency Virus

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Genotypic Antiretroviral Resistance Testing for Human Immunodeficiency Virus Type 1 Integrase Inhibitors by Use of the TruGene Sequencing System

Journal of Clinical Microbiology ◽

10.1128/jcm.01246-08 ◽

2008 ◽

Vol 46 (12) ◽

pp. 4087-4090 ◽

Cited By ~ 9

Author(s):

C. Paar ◽

C. Palmetshofer ◽

K. Flieger ◽

M. Geit ◽

R. Kaiser ◽

...

Keyword(s):

Human Immunodeficiency Virus ◽

Human Immunodeficiency Virus Type ◽

Virus Type ◽

Resistance Testing ◽

Integrase Inhibitors ◽

Immunodeficiency Virus ◽

Antiretroviral Resistance

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L-2-oxothiazolidine-4-carboxylic acid inhibits human immunodeficiency virus type 1 replication in mononuclear phagocytes and lymphocytes.

Clinical and Diagnostic Laboratory Immunology ◽

10.1128/cdli.4.3.352-357.1997 ◽

1997 ◽

Vol 4 (3) ◽

pp. 352-357 ◽

Cited By ~ 3

Author(s):

W Z Ho ◽

S E Starr ◽

A Sison ◽

S D Douglas

Keyword(s):

Human Immunodeficiency Virus ◽

Carboxylic Acid ◽

Human Immunodeficiency Virus Type ◽

Virus Type ◽

Mononuclear Phagocytes ◽

Immunodeficiency Virus

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Population pharmacokinetics and exposure-response relationship of enfuvirtide in treatment-experienced human immunodeficiency virus type 1—infected patients

Clinical Pharmacology & Therapeutics ◽

10.1016/j.clpt.2005.02.005 ◽

2005 ◽

Vol 77 (6) ◽

pp. 515-528 ◽

Cited By ~ 23

Author(s):

D MOULD ◽

X ZHANG ◽

K NIEFORTH ◽

M SALGO ◽

N BUSS ◽

...

Keyword(s):

Human Immunodeficiency Virus ◽

Population Pharmacokinetics ◽

Human Immunodeficiency Virus Type ◽

Virus Type ◽

Response Relationship ◽

Exposure Response ◽

Immunodeficiency Virus ◽

Relationship Of

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Structure–activity relationship studies of 1-(4-chloro-2,5-dimethoxyphenyl)-3-(3-propoxypropyl)thiourea, a non-nucleoside reverse transcriptase inhibitor of human immunodeficiency virus type-1

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2010.11.003 ◽

2011 ◽

Vol 46 (2) ◽

pp. 447-467 ◽

Cited By ~ 4

Author(s):

Michal Weitman ◽

Keti Lerman ◽

Abraham Nudelman ◽

Dan Thomas Major ◽

Amnon Hizi ◽

...

Keyword(s):

Human Immunodeficiency Virus ◽

Reverse Transcriptase ◽

Human Immunodeficiency Virus Type ◽

Virus Type ◽

Nucleoside Reverse Transcriptase Inhibitor ◽

Transcriptase Inhibitor ◽

Structure Activity ◽

Immunodeficiency Virus ◽

Reverse Transcriptase Inhibitor

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