Design, Synthesis, and Structure−Activity Relationship, Molecular Modeling, and NMR Studies of a Series of Phenyl Alkyl Ketones as Highly Potent and Selective Phosphodiesterase-4 Inhibitors

Shilong Zheng; Gurpreet Kaur; Huanchen Wang; Minyong Li; Megan Macnaughtan; Xiaochuan Yang; Suazette Reid; James Prestegard; Binghe Wang; Hengming Ke

doi:10.1021/jm701635j

Design, Synthesis, and Structure−Activity Relationship, Molecular Modeling, and NMR Studies of a Series of Phenyl Alkyl Ketones as Highly Potent and Selective Phosphodiesterase-4 Inhibitors

Journal of Medicinal Chemistry ◽

10.1021/jm701635j ◽

2008 ◽

Vol 51 (24) ◽

pp. 7673-7688 ◽

Cited By ~ 28

Author(s):

Shilong Zheng ◽

Gurpreet Kaur ◽

Huanchen Wang ◽

Minyong Li ◽

Megan Macnaughtan ◽

...

Keyword(s):

Molecular Modeling ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Nmr Studies ◽

Design Synthesis ◽

Phosphodiesterase 4 ◽

Structure Activity ◽

Phosphodiesterase 4 Inhibitors

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Development of highly potent phosphodiesterase 4 inhibitors with anti-neuroinflammation potential: Design, synthesis, and structure-activity relationship study of catecholamides bearing aromatic rings

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2016.08.052 ◽

2016 ◽

Vol 124 ◽

pp. 372-379 ◽

Cited By ~ 15

Author(s):

Zhong-Zhen Zhou ◽

Bing-Chen Ge ◽

Qiu-Ping Zhong ◽

Chang Huang ◽

Yu-Fang Cheng ◽

...

Keyword(s):

Structure Activity Relationship ◽

Activity Relationship ◽

Aromatic Rings ◽

Design Synthesis ◽

Phosphodiesterase 4 ◽

Structure Activity ◽

Phosphodiesterase 4 Inhibitors ◽

Relationship Study

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Thioether-bridged arylalkyl-linked N-phenylpyrazole derivatives: Design, synthesis, insecticidal activities, structure-activity relationship and molecular-modeling studies

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2018.04.022 ◽

2018 ◽

Vol 28 (10) ◽

pp. 1792-1796 ◽

Cited By ~ 2

Author(s):

Chengcheng Fei ◽

Yanfei Chen ◽

Zhiyan Jiang ◽

Dingxin Jiang

Keyword(s):

Molecular Modeling ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Design Synthesis ◽

Structure Activity ◽

Modeling Studies ◽

Molecular Modeling Studies ◽

Insecticidal Activities

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Discovery of 2‐(3,4‐dialkoxyphenyl)‐2‐(substituted pyridazin‐3‐yl)acetonitriles as phosphodiesterase 4 inhibitors with anti‐neuroinflammation potential based on three‐dimensional quantitative structure–activity relationship study

Chemical Biology & Drug Design ◽

10.1111/cbdd.13438 ◽

2018 ◽

Vol 93 (4) ◽

pp. 484-502 ◽

Cited By ~ 2

Author(s):

Chang Huang ◽

Qiu‐Ping Zhong ◽

Lv Tang ◽

Hai‐Tao Wang ◽

Jiang‐Ping Xu ◽

...

Keyword(s):

Three Dimensional ◽

Quantitative Structure Activity Relationship ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Quantitative Structure ◽

Phosphodiesterase 4 ◽

Structure Activity ◽

Phosphodiesterase 4 Inhibitors ◽

Relationship Study

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Prenylated flavonoids as potent phosphodiesterase-4 inhibitors from Morus alba : Isolation, modification, and structure-activity relationship study

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2017.12.057 ◽

2018 ◽

Vol 144 ◽

pp. 758-766 ◽

Cited By ~ 11

Author(s):

Yan-Qiong Guo ◽

Gui-Hua Tang ◽

Lan-Lan Lou ◽

Wei Li ◽

Bei Zhang ◽

...

Keyword(s):

Structure Activity Relationship ◽

Morus Alba ◽

Activity Relationship ◽

Prenylated Flavonoids ◽

Phosphodiesterase 4 ◽

Structure Activity ◽

Phosphodiesterase 4 Inhibitors ◽

Relationship Study

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Design, Synthesis and Structure-Activity Relationship Studies of Novel 4 (1-adamantyl) Phenyl Analogues as HIF-1α Inhibitors

Medicinal Chemistry ◽

10.2174/1573406412666151109113007 ◽

2016 ◽

Vol 12 (4) ◽

pp. 338-346 ◽

Cited By ~ 2

Author(s):

Yan Xia ◽

Qiong Duan ◽

Bao-Hua Zhao ◽

Dong-Feng Li ◽

Rui-Bin Hou

Keyword(s):

Structure Activity Relationship ◽

Activity Relationship ◽

Design Synthesis ◽

Structure Activity

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Design, synthesis, biological evaluation and structure-activity relationship study of quinazolin-4(3H)-one derivatives as novel USP7 inhibitors

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2021.113291 ◽

2021 ◽

pp. 113291

Author(s):

Peng Li ◽

Ying Liu ◽

Hua Yang ◽

Hong-Min Liu

Keyword(s):

Structure Activity Relationship ◽

Biological Evaluation ◽

Activity Relationship ◽

Design Synthesis ◽

Structure Activity ◽

Relationship Study

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New substituted pyrazolones and dipyrazolotriazines as promising tyrosyl-tRNA synthetase and peroxiredoxin-5 inhibitors: Design, synthesis, molecular docking and structure-activity relationship (SAR) analysis

Bioorganic Chemistry ◽

10.1016/j.bioorg.2021.104704 ◽

2021 ◽

Vol 109 ◽

pp. 104704

Author(s):

Ismail M.M. Othman ◽

Mohamed A.M. Gad-Elkareem ◽

El Hassane Anouar ◽

Kaïss Aouadi ◽

Mejdi Snoussi ◽

...

Keyword(s):

Molecular Docking ◽

Structure Activity Relationship ◽

Trna Synthetase ◽

Activity Relationship ◽

Design Synthesis ◽

Structure Activity ◽

Sar Analysis

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Antileishmanial Chalcones: Statistical Design, Synthesis, and Three-Dimensional Quantitative Structure−Activity Relationship Analysis

Journal of Medicinal Chemistry ◽

10.1021/jm980410m ◽

1998 ◽

Vol 41 (24) ◽

pp. 4819-4832 ◽

Cited By ~ 183

Author(s):

Simon Feldbæk Nielsen ◽

Søren Brøgger Christensen ◽

Gabriele Cruciani ◽

Arsalan Kharazmi ◽

Tommy Liljefors

Keyword(s):

Three Dimensional ◽

Statistical Design ◽

Quantitative Structure Activity Relationship ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Quantitative Structure ◽

Design Synthesis ◽

Relationship Analysis ◽

Structure Activity

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Novel Pyrazole-4-acetohydrazide Derivatives Potentially Targeting Fungal Succinate Dehydrogenase: Design, Synthesis, Three-Dimensional Quantitative Structure–Activity Relationship, and Molecular Docking

Journal of Agricultural and Food Chemistry ◽

10.1021/acs.jafc.1c03399 ◽

2021 ◽

Author(s):

Xiaobin Wang ◽

Mengqi Wang ◽

Ling Han ◽

Fei Jin ◽

Jian Jiao ◽

...

Keyword(s):

Molecular Docking ◽

Succinate Dehydrogenase ◽

Three Dimensional ◽

Quantitative Structure Activity Relationship ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Quantitative Structure ◽

Design Synthesis ◽

Structure Activity

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Design, synthesis and structure–activity relationship (SAR) studies of imidazo[4,5-b]pyridine derived purine isosteres and their potential as cytotoxic agents

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2014.10.037 ◽

2015 ◽

Vol 89 ◽

pp. 21-31 ◽

Cited By ~ 26

Author(s):

Ayyiliath M. Sajith ◽

K.K. Abdul Khader ◽

Nithin Joshi ◽

Manchala Nageswar Reddy ◽

M. Syed Ali Padusha ◽

...

Keyword(s):

Structure Activity Relationship ◽

Cytotoxic Agents ◽

Activity Relationship ◽

Design Synthesis ◽

Sar Studies ◽

Structure Activity

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