2-Amino-1,3-thiazol-4(5H)-ones as Potent and Selective 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitors: Enzyme−Ligand Co-Crystal Structure and Demonstration of Pharmacodynamic Effects in C57Bl/6 Mice

2008 ◽  
Vol 51 (10) ◽  
pp. 2933-2943 ◽  
Author(s):  
Lars Johansson ◽  
Christopher Fotsch ◽  
Michael D. Bartberger ◽  
Victor M. Castro ◽  
Michelle Chen ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Hydroxysteroid Dehydrogenase ◽  
Pharmacodynamic Effects

scholarly journals The Crystal Structure of Guinea Pig 11β-Hydroxysteroid Dehydrogenase Type 1 Provides a Model for Enzyme-Lipid Bilayer Interactions

2004 ◽  
Vol 280 (5) ◽  
pp. 3789-3794 ◽  
Author(s):  
Derek Ogg ◽  
Björn Elleby ◽  
Carina Norström ◽  
Karin Stefansson ◽  
Lars Abrahmsén ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Guinea Pig ◽  
Lipid Bilayer ◽  
Hydroxysteroid Dehydrogenase

Structural Characterization and Pharmacodynamic Effects of an Orally Active 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitor

2007 ◽  
Vol 71 (1) ◽  
pp. 36-44 ◽  
Author(s):  
Clarence Hale ◽  
Murielle Véniant ◽  
Zhulun Wang ◽  
Michelle Chen ◽  
Jocelyn McCormick ◽  
...  
Keyword(s):  
Structural Characterization ◽  
Hydroxysteroid Dehydrogenase ◽  
Pharmacodynamic Effects ◽  
Orally Active

The role of hepatic 11[b]-hydroxysteroid dehydrogenase type 1 in cholesterol homeostasis

2013 ◽  
pp. 1-1
Author(s):  
Kajal Manwani ◽  
Tak Y Man ◽  
Christopher J Kenyon ◽  
Ruth Andrew ◽  
Karen E Chapman ◽  
...  
Keyword(s):  
Hydroxysteroid Dehydrogenase ◽  
Cholesterol Homeostasis

Macrophage-specific 11b-hydroxysteroid dehydrogenase type 1 deficiency promotes angiogenesis but impairs resolution of K/BxN serum induced arthritis

2013 ◽  
pp. 1-1
Author(s):  
Zhenguang Zhang ◽  
Agnes Coutinho ◽  
Patrick Hadoke ◽  
Donald Salter ◽  
Jonathan Seckl ◽  
...  
Keyword(s):  
Hydroxysteroid Dehydrogenase

Suppression of 11[beta]-hydroxysteroid dehydrogenase type 1 target gene regulation by hypoxia

2016 ◽  
Author(s):  
Bushra Shammout ◽  
Adewonuola Alase ◽  
Miriam Wittmann ◽  
Paul Stewart ◽  
Ana Tiganescu
Keyword(s):  
Gene Regulation ◽  
Target Gene ◽  
Hydroxysteroid Dehydrogenase
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