Enhanced Concentration-Dependent Cytotoxic Effect of the Dinuclear Copper(II) Complex ofl-Carnitine [Cu2(l-carnitine)2Cl2(H2O)2]Cl2, Compared tol-Carnitine or Copper Chloride Dihydrate, in Human Leukemic Cell Lines

2008 ◽  
Vol 51 (13) ◽  
pp. 3713-3719 ◽  
Author(s):  
Hellinida Thomadaki ◽  
Alexandra Karaliota ◽  
Charalambos Litos ◽  
Andreas Scorilas
Keyword(s):  
Cell Lines ◽  
Cytotoxic Effect ◽  
Copper Chloride ◽  
Leukemic Cell ◽  
Dinuclear Copper ◽  
Chloride Dihydrate ◽  
Human Leukemic Cell ◽  
Leukemic Cell Lines

scholarly journals The effects of alkyl-lysophospholipids on leukemic cell lines. I. Differential action on two human leukemic cell lines, HL60 and K562

Blood ◽  
1981 ◽  
Vol 57 (4) ◽  
pp. 794-797 ◽  
Author(s):  
T Tidwell ◽  
G Guzman ◽  
WR Vogler
Keyword(s):  
Bone Marrow ◽  
Cell Lines ◽  
Leukemic Cell ◽  
Short Term ◽  
Cell Numbers ◽  
Human Leukemic Cell ◽  
Leukemic Cell Lines ◽  
Low Concentrations ◽  
Bone Marrow Cultures ◽  
Differential Action

Abstract The action of an alkyl-lysophospholipid (ALP), ET180CH3, on clonogenicity, 3H-TdR uptake, and cell numbers was tested in two human leukemic cell lines, HL60 and K562, and short-term human leukemic bone marrow cultures. ALP eliminated clonogenicity in HL60 but not in K562 cultures; 3H-TdR uptake and cell numbers were depressed at low concentrations of ET180CH3 in HL60, but not K562 cultures. The action of the lysophospholipid analog on human leukemic bone marrow short-term cultures at low concentrations was similar to its action on HL60 cultures; clonogenicity and 3H-TdR uptake were depressed, but cell numbers were not significantly affected. The demonstration of differential action of ALP on two cell lines should significantly simplify the investigation of the mechanism of the reported differential action of ET180CH3 on normal and leukemic cell membranes.

scholarly journals Effect of nordihydroguaiaretic acid on cell viability and glucose transport in human leukemic cell lines

FEBS Open Bio ◽  
2016 ◽  
Vol 6 (10) ◽  
pp. 1000-1007 ◽  
Author(s):  
David Leon ◽  
Daniela Parada ◽  
Mauricio Vargas‐Uribe ◽  
Alejandra A. Perez ◽  
Lorena Ojeda ◽  
...  
Keyword(s):  
Cell Viability ◽  
Glucose Transport ◽  
Cell Lines ◽  
Leukemic Cell ◽  
Nordihydroguaiaretic Acid ◽  
Human Leukemic Cell ◽  
Leukemic Cell Lines

scholarly journals Signal transduction and glycophosphatidylinositol-linked proteins (lyn, lck, CD4, CD45, G proteins, and CD55) selectively localize in Triton- insoluble plasma membrane domains of human leukemic cell lines and normal granulocytes

Blood ◽  
1996 ◽  
Vol 87 (9) ◽  
pp. 3783-3794 ◽  
Author(s):  
I Parolini ◽  
M Sargiacomo ◽  
MP Lisanti ◽  
C Peschle
Keyword(s):  
Signal Transduction ◽  
G Proteins ◽  
Cell Lines ◽  
Tyrosine Kinases ◽  
Leukemic Cell ◽  
Receptor Activation ◽  
Leukemic Cells ◽  
Human Leukemic Cell ◽  
Leukemic Cell Lines ◽  
B Lymphoid

Src-family nonreceptor protein tyrosine kinases (NRPTK) are associated with cell surface receptors in large detergent-resistant complexes: in epithelial cells, yes is selectively located in vesicle structures containing caveolin (“caveolae”). These formations are typically also endowed with glycophosphatidylinositol (GPI)-anchored proteins. In the present study, we observed lck, lyn, src, hck, CD4, CD45, G proteins, and CD55 (decay-accelerating factor) expression in the buoyant low- density Triton-insoluble (LDTI) fraction of selected leukemic cell lines and granulocytes. We provide a detailed analysis of the two most highly expressed NRPTK, p53/p56lyn and p56lck, which are involved in the transduction of signals for proliferation and differentiation of monocytes/B lymphocytes and T lymphocytes, respectively. We show that lyn is selectively recovered in LDTI complexes isolated from human leukemic cell lines (promyelocytic [HL-60], erythroid [K562] and B- lymphoid [697]) and from normal human granulocytes, and that lck is recovered from LDTI fractions of leukemic T- and B-lymphoid cell lines (CEM, 697). In LDTI fractions of leukemic cells, lck and lyn are enriched 100-fold as compared with the total cell lysates. Analysis of these fractions by electron microscopy shows the presence of 70- to 200- nm vesicles: lyn and lck are homogenously distributed in the vesicles, as revealed by an immunogold labeling procedure. These novel results propose a role for these vesicles in signal transduction mechanisms of normal and neoplastic hematopoietic cells. In support of this hypothesis, we further observed that molecules participating in B- and T-cell receptor activation cofractionate in the LDTI fractions, CD45/lyn (B cells) and CD45/lck/CD4 (T cells).

scholarly journals Methoxyflavone derivatives modulate the effect of TRAIL-induced apoptosis in human leukemic cell lines

2011 ◽  
Vol 4 (1) ◽  
pp. 52 ◽  
Author(s):  
Benjawan Wudtiwai ◽  
Bungorn Sripanidkulchai ◽  
Prachya Kongtawelert ◽  
Ratana Banjerdpongchai
Keyword(s):  
Cell Lines ◽  
Leukemic Cell ◽  
Human Leukemic Cell ◽  
Leukemic Cell Lines ◽  
Induced Apoptosis
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