Validation of Diacyl Glycerolacyltransferase I as a Novel Target for the Treatment of Obesity and Dyslipidemia Using a Potent and Selective Small Molecule Inhibitor

Gang Zhao; Andrew J. Souers; Martin Voorbach; H. Doug Falls; Brian Droz; Sevan Brodjian; Yau Yi Lau; Rajesh R. Iyengar; Ju Gao; Andrew S. Judd; Seble H. Wagaw; Matthew M. Ravn; Kenneth M. Engstrom; John K. Lynch; Mathew M. Mulhern; Jennifer Freeman; Brian D. Dayton; Xiaojun Wang; Nelson Grihalde; Dennis Fry; David W. A. Beno; Kennan C. Marsh; Zhi Su; Gilbert J. Diaz; Christine A. Collins; Hing Sham; Regina M. Reilly; Michael E. Brune; Philip R. Kym

doi:10.1021/jm7013887

Validation of Diacyl Glycerolacyltransferase I as a Novel Target for the Treatment of Obesity and Dyslipidemia Using a Potent and Selective Small Molecule Inhibitor

Journal of Medicinal Chemistry ◽

10.1021/jm7013887 ◽

2008 ◽

Vol 51 (3) ◽

pp. 380-383 ◽

Cited By ~ 104

Author(s):

Gang Zhao ◽

Andrew J. Souers ◽

Martin Voorbach ◽

H. Doug Falls ◽

Brian Droz ◽

...

Keyword(s):

Small Molecule ◽

Small Molecule Inhibitor ◽

Molecule Inhibitor ◽

Treatment Of Obesity ◽

Novel Target

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Faculty Opinions recommendation of Validation of diacyl glycerolacyltransferase I as a novel target for the treatment of obesity and dyslipidemia using a potent and selective small molecule inhibitor.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1101134.557118 ◽

2008 ◽

Author(s):

Thomas W von Geldern

Keyword(s):

Small Molecule ◽

Small Molecule Inhibitor ◽

Molecule Inhibitor ◽

Treatment Of Obesity ◽

Novel Target

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Abstract 1169: Characterization of a small molecule inhibitor for GD3 synthase (ST8SIA1), a novel target in breast cancer stem-like cells

10.1158/1538-7445.sabcs18-1169 ◽

2019 ◽

Author(s):

Appalaraju Jappupilli ◽

Khoa Nguyen ◽

Stanley Ly ◽

Michael Andreeff ◽

Prashen Chelikani ◽

...

Keyword(s):

Breast Cancer ◽

Small Molecule ◽

Small Molecule Inhibitor ◽

Molecule Inhibitor ◽

Gd3 Synthase ◽

Novel Target

Download Full-text

Abstract 1169: Characterization of a small molecule inhibitor for GD3 synthase (ST8SIA1), a novel target in breast cancer stem-like cells

10.1158/1538-7445.am2019-1169 ◽

2019 ◽

Author(s):

Appalaraju Jappupilli ◽

Khoa Nguyen ◽

Stanley Ly ◽

Michael Andreeff ◽

Prashen Chelikani ◽

...

Keyword(s):

Breast Cancer ◽

Small Molecule ◽

Small Molecule Inhibitor ◽

Molecule Inhibitor ◽

Gd3 Synthase ◽

Novel Target

Download Full-text

Faculty Opinions recommendation of Suppression of the Shh pathway using a small molecule inhibitor eliminates medulloblastoma in Ptc1(+/-)p53(-/-) mice.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1021658.247635 ◽

2004 ◽

Author(s):

William Kaelin

Keyword(s):

Small Molecule ◽

Small Molecule Inhibitor ◽

Shh Pathway ◽

Molecule Inhibitor

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Faculty Opinions recommendation of Suppression of HIV-1 infection by a small molecule inhibitor of the ATM kinase.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1025625.322882 ◽

2005 ◽

Author(s):

James Stivers

Keyword(s):

Small Molecule ◽

Small Molecule Inhibitor ◽

Atm Kinase ◽

Molecule Inhibitor ◽

Hiv 1

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Faculty Opinions recommendation of Selective small-molecule inhibitor reveals critical mitotic functions of human CDK1.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1033159.375732 ◽

2006 ◽

Author(s):

Berl R Oakley

Keyword(s):

Small Molecule ◽

Small Molecule Inhibitor ◽

Molecule Inhibitor

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Faculty Opinions recommendation of The small-molecule inhibitor BI 2536 reveals novel insights into mitotic roles of polo-like kinase 1.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1066069.520680 ◽

2007 ◽

Author(s):

Nathanael Gray

Keyword(s):

Small Molecule ◽

Small Molecule Inhibitor ◽

Molecule Inhibitor ◽

Bi 2536

Download Full-text

Faculty Opinions recommendation of The small-molecule inhibitor BI 2536 reveals novel insights into mitotic roles of polo-like kinase 1.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1066069.519039 ◽

2007 ◽

Author(s):

Tarun Kapoor

Keyword(s):

Small Molecule ◽

Small Molecule Inhibitor ◽

Molecule Inhibitor ◽

Bi 2536

Download Full-text

Faculty Opinions recommendation of Identification and characterization of a small molecule inhibitor of formin-mediated actin assembly.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1283961.751061 ◽

2009 ◽

Author(s):

Marie-France Carlier

Keyword(s):

Small Molecule ◽

Small Molecule Inhibitor ◽

Actin Assembly ◽

Molecule Inhibitor ◽

Identification And Characterization

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Faculty Opinions recommendation of Regression of castrate-recurrent prostate cancer by a small-molecule inhibitor of the amino-terminus domain of the androgen receptor.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.5059957.4994055 ◽

2010 ◽

Author(s):

Michael Weber ◽

Daniel G Gioeli

Keyword(s):

Prostate Cancer ◽

Androgen Receptor ◽

Small Molecule ◽

Small Molecule Inhibitor ◽

Amino Terminus ◽

Recurrent Prostate Cancer ◽

Molecule Inhibitor

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