Discovery of Novel Small-Molecule Inhibitors of Human Epidermal Growth Factor Receptor-2: Combined Ligand and Target-Based Approach

Rambabu Gundla; Roza Kazemi; Ramadevi Sanam; Ravikumar Muttineni; Jagarlapudi A. R. P. Sarma; Raveendra Dayam; Nouri Neamati

doi:10.1021/jm7013875

Discovery of Novel Small-Molecule Inhibitors of Human Epidermal Growth Factor Receptor-2: Combined Ligand and Target-Based Approach

Journal of Medicinal Chemistry ◽

10.1021/jm7013875 ◽

2008 ◽

Vol 51 (12) ◽

pp. 3367-3377 ◽

Cited By ~ 84

Author(s):

Rambabu Gundla ◽

Roza Kazemi ◽

Ramadevi Sanam ◽

Ravikumar Muttineni ◽

Jagarlapudi A. R. P. Sarma ◽

...

Keyword(s):

Epidermal Growth Factor Receptor ◽

Growth Factor ◽

Epidermal Growth Factor ◽

Small Molecule ◽

Small Molecule Inhibitors ◽

Growth Factor Receptor ◽

Human Epidermal Growth Factor ◽

Epidermal Growth

Download Full-text

Resistance to small molecule inhibitors of epidermal growth factor receptor in malignant gliomas

International Journal of Radiation Oncology*Biology*Physics ◽

10.1016/s0360-3016(03)01152-0 ◽

2003 ◽

Vol 57 (2) ◽

pp. S293-S294 ◽

Cited By ~ 4

Author(s):

B Li ◽

C Chang ◽

M Yuan ◽

H.G Shu

Keyword(s):

Epidermal Growth Factor Receptor ◽

Growth Factor ◽

Epidermal Growth Factor ◽

Small Molecule ◽

Small Molecule Inhibitors ◽

Malignant Gliomas ◽

Growth Factor Receptor ◽

Epidermal Growth

Download Full-text

The exosomal compartment protects epidermal growth factor receptor from small molecule inhibitors

Biochemical and Biophysical Research Communications ◽

10.1016/j.bbrc.2018.12.187 ◽

2019 ◽

Vol 510 (1) ◽

pp. 42-47

Author(s):

Yu Hung ◽

Yuan-Liang Wang ◽

You-Zhe Lin ◽

Shu-Fen Chiang ◽

Wan-Rong Wu ◽

...

Keyword(s):

Epidermal Growth Factor Receptor ◽

Growth Factor ◽

Epidermal Growth Factor ◽

Small Molecule ◽

Small Molecule Inhibitors ◽

Growth Factor Receptor ◽

Epidermal Growth

Download Full-text

Lapatinib: A small-molecule inhibitor of epidermal growth factor receptor and human epidermal growth factor receptor—2 tyrosine kinases used in the treatment of breast cancer

Clinical Therapeutics ◽

10.1016/j.clinthera.2009.11.029 ◽

2009 ◽

Vol 31 ◽

pp. 2332-2348 ◽

Cited By ~ 56

Author(s):

Amye J. Tevaarwerk ◽

Jill M. Kolesar

Keyword(s):

Breast Cancer ◽

Epidermal Growth Factor Receptor ◽

Growth Factor ◽

Epidermal Growth Factor ◽

Small Molecule ◽

Tyrosine Kinases ◽

Growth Factor Receptor ◽

Human Epidermal Growth Factor ◽

Molecule Inhibitor ◽

Epidermal Growth

Download Full-text

In silico identification of potent small molecule inhibitors targeting epidermal growth factor receptor 1

Journal of Cancer Research and Therapeutics ◽

10.4103/jcrt.jcrt_365_17 ◽

2018 ◽

Vol 14 (1) ◽

pp. 18 ◽

Cited By ~ 1

Author(s):

Lijia Cheng ◽

Xiaoheng Guo ◽

Zheng Shi ◽

Jie Chen ◽

Xiaolan Guo ◽

...

Keyword(s):

Epidermal Growth Factor Receptor ◽

Growth Factor ◽

Epidermal Growth Factor ◽

Small Molecule ◽

In Silico ◽

Small Molecule Inhibitors ◽

Growth Factor Receptor ◽

Epidermal Growth ◽

In Silico Identification

Download Full-text

Small Molecule Inhibitors of the Epidermal Growth Factor Receptor

Topics in Medicinal Chemistry - Cancer II ◽

10.1007/7355_2016_26 ◽

2017 ◽

pp. 39-39 ◽

Cited By ~ 2

Author(s):

M. Raymond V. Finlay ◽

Richard A. Ward

Keyword(s):

Epidermal Growth Factor Receptor ◽

Growth Factor ◽

Epidermal Growth Factor ◽

Small Molecule ◽

Small Molecule Inhibitors ◽

Growth Factor Receptor ◽

Epidermal Growth

Download Full-text

DETECT V – Nachweis von Östrogenrezeptor und Human Epidermal Growth Factor Receptor 2 mittels CellSearch CXC Kit

Senologie - Zeitschrift für Mammadiagnostik und -therapie ◽

10.1055/s-0036-1583408 ◽

2016 ◽

Vol 13 (02) ◽

Author(s):

F Meier-Stiegen ◽

S Riethdorf ◽

A Schramm ◽

A Polasik ◽

D Niederacher ◽

...

Keyword(s):

Epidermal Growth Factor Receptor ◽

Growth Factor ◽

Epidermal Growth Factor ◽

Growth Factor Receptor ◽

Human Epidermal Growth Factor ◽

Epidermal Growth

Download Full-text

Detection of Human Epidermal Growth Factor Receptor 2 through ICC and FISH in Formalin-Fixed Breast Carcinoma from Cell Block and Correlation of Results to Corresponding Histological Specimens

10.26226/morressier.57d6b2bdd462b8028d88cd87 ◽

2016 ◽

Author(s):

Divya Verma

Keyword(s):

Epidermal Growth Factor Receptor ◽

Growth Factor ◽

Breast Carcinoma ◽

Epidermal Growth Factor ◽

Growth Factor Receptor ◽

Cell Block ◽

Human Epidermal Growth Factor ◽

Epidermal Growth ◽

Formalin Fixed

Download Full-text

Real World Study of Pyrotinib in Human Epidermal Growth Factor Receptor-2 (HER2) Positive Breast Cancer

Case Medical Research ◽

10.31525/ct1-nct04158505 ◽

2019 ◽

Author(s):

Keyword(s):

Breast Cancer ◽

Epidermal Growth Factor Receptor ◽

Growth Factor ◽

Epidermal Growth Factor ◽

Real World ◽

Growth Factor Receptor ◽

Her2 Positive ◽

Human Epidermal Growth Factor ◽

Epidermal Growth ◽

Positive Breast Cancer

Download Full-text

Prognostic significance of Human epidermal growth factor receptor-2 expression in patients with resectable gastric adenocarcinoma

World Journal of Surgical Oncology ◽

10.1186/s12957-019-1652-2 ◽

2019 ◽

Vol 17 (1) ◽

Cited By ~ 1

Author(s):

Hyeongbin Kim ◽

SangHyuk Seo ◽

KwangHee Kim ◽

Yo-Han Park ◽

MinSung An ◽

...

Keyword(s):

Epidermal Growth Factor Receptor ◽

Growth Factor ◽

Epidermal Growth Factor ◽

Gastric Adenocarcinoma ◽

Prognostic Significance ◽

Growth Factor Receptor ◽

Human Epidermal Growth Factor ◽

Epidermal Growth

Download Full-text

An evaluation on clinico-pathologic correlation and outcome of human epidermal growth factor receptor 2 subgroups reclassified according to the latest ASCO/CAP guideline

Clinical Breast Cancer ◽

10.1016/j.clbc.2021.05.005 ◽

2021 ◽

Author(s):

Chao Wang ◽

Julia Y Tsang ◽

Ivan K Poon ◽

Yan Shao ◽

Joshua J Li ◽

...

Keyword(s):

Epidermal Growth Factor Receptor ◽

Growth Factor ◽

Epidermal Growth Factor ◽

Growth Factor Receptor ◽

Human Epidermal Growth Factor ◽

Pathologic Correlation ◽

Epidermal Growth

Download Full-text