Synthesis and In Vitro Opioid Receptor Functional Antagonism of Analogues of the Selective Kappa Opioid Receptor Antagonist (3R)-7-Hydroxy-N-((1S)-1-{[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl}-2-methylpropyl)-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide (JDTic)

Tingwei Bill Cai; Zhou Zou; James B. Thomas; Larry Brieaddy; Hernán A. Navarro; F. Ivy Carroll

doi:10.1021/jm701344b

Synthesis and In Vitro Opioid Receptor Functional Antagonism of Analogues of the Selective Kappa Opioid Receptor Antagonist (3R)-7-Hydroxy-N-((1S)-1-{[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl}-2-methylpropyl)-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide (JDTic)

Journal of Medicinal Chemistry ◽

10.1021/jm701344b ◽

2008 ◽

Vol 51 (6) ◽

pp. 1849-1860 ◽

Cited By ~ 19

Author(s):

Tingwei Bill Cai ◽

Zhou Zou ◽

James B. Thomas ◽

Larry Brieaddy ◽

Hernán A. Navarro ◽

...

Keyword(s):

Receptor Antagonist ◽

Opioid Receptor ◽

Kappa Opioid Receptor ◽

Kappa Opioid ◽

Opioid Receptor Antagonist ◽

Functional Antagonism

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Faculty Opinions recommendation of Chronic peripheral administration of kappa-opioid receptor antagonist advances puberty onset associated with acceleration of pulsatile luteinizing hormone secretion in female rats.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718110987.793483835 ◽

2013 ◽

Author(s):

Pamela Mellon ◽

Alexander Kauffman

Keyword(s):

Luteinizing Hormone ◽

Receptor Antagonist ◽

Opioid Receptor ◽

Hormone Secretion ◽

Kappa Opioid Receptor ◽

Female Rats ◽

Luteinizing Hormone Secretion ◽

Kappa Opioid ◽

Opioid Receptor Antagonist ◽

Puberty Onset

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Itching-like behavior: A common effect of the kappa opioid receptor antagonist 5'-guanidinonaltrindole and the biased kappa opioid receptor agonist 6'-guanidinonaltrindole in mice

Medicine in Drug Discovery ◽

10.1016/j.medidd.2021.100097 ◽

2021 ◽

pp. 100097

Author(s):

Alan Cowan ◽

Lee-Yuan Liu-Chen ◽

Saadet Inan

Keyword(s):

Receptor Antagonist ◽

Opioid Receptor ◽

Receptor Agonist ◽

Kappa Opioid Receptor ◽

Kappa Opioid ◽

Opioid Receptor Antagonist ◽

Common Effect ◽

Opioid Receptor Agonist

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Attenuation of cannabinoid-induced inhibition of medullary dorsal horn neurons by a kappa-opioid receptor antagonist

Brain Research ◽

10.1016/j.brainres.2010.08.073 ◽

2010 ◽

Vol 1359 ◽

pp. 81-89 ◽

Cited By ~ 3

Author(s):

Akiko Okada-Ogawa ◽

Masayuki Kurose ◽

Ian D. Meng

Keyword(s):

Receptor Antagonist ◽

Dorsal Horn ◽

Opioid Receptor ◽

Kappa Opioid Receptor ◽

Kappa Opioid ◽

Dorsal Horn Neurons ◽

Opioid Receptor Antagonist ◽

Medullary Dorsal Horn

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Modeling analysis of the new kappa opioid receptor antagonist tracer [11C]LY2795050 in humans

NeuroImage ◽

10.1016/j.neuroimage.2010.04.221 ◽

2010 ◽

Vol 52 ◽

pp. S39

Author(s):

Giampaolo Tomasi ◽

Shu-Fei Lin ◽

Ming Zheng ◽

Beata Planeta-Wilson ◽

S. Henry ◽

...

Keyword(s):

Receptor Antagonist ◽

Opioid Receptor ◽

Kappa Opioid Receptor ◽

Kappa Opioid ◽

Opioid Receptor Antagonist ◽

Modeling Analysis

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Reinstatement of cocaine place-conditioning prevented by the peptide kappa-opioid receptor antagonist arodyn

European Journal of Pharmacology ◽

10.1016/j.ejphar.2007.05.007 ◽

2007 ◽

Vol 569 (1-2) ◽

pp. 84-89 ◽

Cited By ~ 90

Author(s):

A.N. Carey ◽

K. Borozny ◽

J.V. Aldrich ◽

J.P. McLaughlin

Keyword(s):

Receptor Antagonist ◽

Opioid Receptor ◽

Kappa Opioid Receptor ◽

Place Conditioning ◽

Kappa Opioid ◽

Opioid Receptor Antagonist

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Activation of tuberohypophysial dopamine neurons following intracerebroventricular administration of the selective kappa opioid receptor antagonist nor-binaltorphimine

Life Sciences ◽

10.1016/0024-3205(91)90451-g ◽

1991 ◽

Vol 48 (12) ◽

pp. 1143-1149 ◽

Cited By ~ 14

Author(s):

Jorge Manzanares ◽

Keith J. Lookingland ◽

Suzette D. LaVigne ◽

Kenneth E. Moore

Keyword(s):

Receptor Antagonist ◽

Opioid Receptor ◽

Kappa Opioid Receptor ◽

Dopamine Neurons ◽

Intracerebroventricular Administration ◽

Kappa Opioid ◽

Opioid Receptor Antagonist

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Buprenorphine has potent kappa opioid receptor antagonist activity

Neuropharmacology ◽

10.1016/0028-3908(87)90112-2 ◽

1987 ◽

Vol 26 (9) ◽

pp. 1445-1447 ◽

Cited By ~ 81

Author(s):

J LEANDER

Keyword(s):

Receptor Antagonist ◽

Opioid Receptor ◽

Kappa Opioid Receptor ◽

Antagonist Activity ◽

Kappa Opioid ◽

Opioid Receptor Antagonist

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Comparison of the kappa-opioid receptor antagonist DIPPA in tests of anxiety-like behavior between Wistar Kyoto and Sprague Dawley rats

Psychopharmacology ◽

10.1007/s00213-010-1832-9 ◽

2010 ◽

Vol 210 (2) ◽

pp. 295-302 ◽

Cited By ~ 39

Author(s):

Gregory V. Carr ◽

Irwin Lucki

Keyword(s):

Receptor Antagonist ◽

Opioid Receptor ◽

Kappa Opioid Receptor ◽

Sprague Dawley ◽

Kappa Opioid ◽

Opioid Receptor Antagonist ◽

Sprague Dawley Rats ◽

Wistar Kyoto

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Nalbuphine, a kappa opioid receptor agonist and mu opioid receptor antagonist attenuates pruritus, decreases IL-31, and increases IL-10 in mice with contact dermatitis

European Journal of Pharmacology ◽

10.1016/j.ejphar.2019.172702 ◽

2019 ◽

Vol 864 ◽

pp. 172702 ◽

Cited By ~ 8

Author(s):

Saadet Inan ◽

Alvaro Torres-Huerta ◽

Liselotte E. Jensen ◽

Nae J. Dun ◽

Alan Cowan

Keyword(s):

Contact Dermatitis ◽

Receptor Antagonist ◽

Opioid Receptor ◽

Receptor Agonist ◽

Mu Opioid Receptor ◽

Kappa Opioid Receptor ◽

Kappa Opioid ◽

Mu Opioid ◽

Opioid Receptor Antagonist ◽

Opioid Receptor Agonist

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Kappa-opioid receptor antagonist norbinaltorphimine's effect on opioid withdrawal-induced somatic symptoms and sleep disturbances

10.36934/tr2021_230 ◽

2021 ◽

Author(s):

Daniel Hahn

Keyword(s):

Receptor Antagonist ◽

Opioid Receptor ◽

Sleep Disturbances ◽

Somatic Symptoms ◽

Opioid Withdrawal ◽

Kappa Opioid Receptor ◽

Kappa Opioid ◽

Opioid Receptor Antagonist

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