Novel Non-Peptide Nociceptin/Orphanin FQ Receptor Agonist, 1-[1-(1-Methylcyclooctyl)-4-piperidinyl]-2-[(3R)-3-piperidinyl]-1H-benzimidazole: Design, Synthesis, and Structure−Activity Relationship of Oral Receptor Occupancy in the Brain for Orally Potent Antianxiety Drug(1, 2)

2009 ◽  
Vol 52 (3) ◽  
pp. 610-625 ◽  
Author(s):  
Shigeo Hayashi ◽  
Akiko Hirao ◽  
Aki Imai ◽  
Hiroshi Nakamura ◽  
Yoshinori Murata ◽  
...  
Keyword(s):  
Receptor Agonist ◽  
Receptor Occupancy ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Orphanin Fq ◽  
Design Synthesis ◽  
Structure Activity ◽  
Antianxiety Drug ◽  
Relationship Of ◽  
The Brain

Design, synthesis and structure–activity relationship of simple bis-amides as potent inhibitors of GlyT1

2008 ◽  
Vol 18 (20) ◽  
pp. 5533-5536 ◽  
Author(s):  
Synèse Jolidon ◽  
Daniela Alberati ◽  
Adam Dowle ◽  
Holger Fischer ◽  
Dominik Hainzl ◽  
...  
Keyword(s):  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Design Synthesis ◽  
Structure Activity ◽  
Relationship Of

Triple reuptake inhibitors: Design, synthesis and structure–activity relationship of benzylpiperidine–tetrazoles

2017 ◽  
Vol 25 (20) ◽  
pp. 5278-5289 ◽  
Author(s):  
Suresh Paudel ◽  
Xiao Min ◽  
Srijan Acharya ◽  
Daulat Bikram Khadka ◽  
Goo Yoon ◽  
...  
Keyword(s):  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Design Synthesis ◽  
Structure Activity ◽  
Relationship Of

Design, synthesis and the structure-activity relationship of agonists targeting on the ALDH2 catalytic tunnel

2020 ◽  
Vol 104 ◽  
pp. 104166
Author(s):  
Ming-Che Cheng ◽  
Wei-Chi Lo ◽  
Yu-Wen Chang ◽  
Shoei-Sheng Lee ◽  
Chia-Chuan Chang
Keyword(s):  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Design Synthesis ◽  
Structure Activity ◽  
Relationship Of
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