Activation of the γ-Aminobutyric Acid Type B (GABAB) Receptor by Agonists and Positive Allosteric Modulators

Katie M. Brown; Kuldeep K. Roy; Gregory H. Hockerman; Robert J. Doerksen; David A. Colby

doi:10.1021/jm5018913

Activation of the γ-Aminobutyric Acid Type B (GABAB) Receptor by Agonists and Positive Allosteric Modulators

Journal of Medicinal Chemistry ◽

10.1021/jm5018913 ◽

2015 ◽

Vol 58 (16) ◽

pp. 6336-6347 ◽

Cited By ~ 21

Author(s):

Katie M. Brown ◽

Kuldeep K. Roy ◽

Gregory H. Hockerman ◽

Robert J. Doerksen ◽

David A. Colby

Keyword(s):

Gabab Receptor ◽

Aminobutyric Acid ◽

Allosteric Modulators ◽

Type B ◽

Acid Type ◽

Positive Allosteric Modulators

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Synthesis and Pharmacological Evaluation of Novel γ-Aminobutyric Acid Type B (GABAB) Receptor Agonists as Gastroesophageal Reflux Inhibitors

Journal of Medicinal Chemistry ◽

10.1021/jm701425k ◽

2008 ◽

Vol 51 (14) ◽

pp. 4315-4320 ◽

Cited By ~ 32

Author(s):

Christer Alstermark ◽

Kosrat Amin ◽

Sean R. Dinn ◽

Thomas Elebring ◽

Ola Fjellström ◽

...

Keyword(s):

Gastroesophageal Reflux ◽

Gabab Receptor ◽

Aminobutyric Acid ◽

Type B ◽

Receptor Agonists ◽

Pharmacological Evaluation ◽

Acid Type

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Dose-Response Effect of Lesogaberan, a Novel γ-Aminobutyric Acid Type B (GABAB) Receptor Agonist, on Reflux Episodes in Patients With Gastroesophageal Reflux Disease With Symptoms Despite Proton Pump Inhibitor Treatment

Gastroenterology ◽

10.1016/s0016-5085(11)62394-9 ◽

2011 ◽

Vol 140 (5) ◽

pp. S-578 ◽

Cited By ~ 2

Author(s):

Philip B. Miner ◽

Debra G. Silberg ◽

Magnus Ruth ◽

Frank Miller ◽

John E. Pandolfino

Keyword(s):

Gastroesophageal Reflux Disease ◽

Proton Pump Inhibitor ◽

Receptor Agonist ◽

Gabab Receptor ◽

Aminobutyric Acid ◽

Type B ◽

Proton Pump Inhibitor Treatment ◽

Acid Type ◽

Dose Response Effect ◽

Inhibitor Treatment

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Evaluation of Difluoromethyl Ketones as Agonists of the γ-Aminobutyric Acid Type B (GABAB) Receptor

Journal of Medicinal Chemistry ◽

10.1021/jm301805e ◽

2013 ◽

Vol 56 (6) ◽

pp. 2456-2465 ◽

Cited By ~ 55

Author(s):

Changho Han ◽

Amy E. Salyer ◽

Eun Hoo Kim ◽

Xinyi Jiang ◽

Rachel E. Jarrard ◽

...

Keyword(s):

Gabab Receptor ◽

Aminobutyric Acid ◽

Type B ◽

Acid Type

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The gamma-aminobutyric acid type B (GABAB) receptor agonist baclofen inhibits morphine sensitization by decreasing the dopamine level in rat nucleus accumbens

Behavioral and Brain Functions ◽

10.1186/1744-9081-8-20 ◽

2012 ◽

Vol 8 (1) ◽

pp. 20 ◽

Cited By ~ 14

Author(s):

Zhenyu Fu ◽

Hongfa Yang ◽

Yuqiang Xiao ◽

Gang Zhao ◽

Haiyan Huang

Keyword(s):

Nucleus Accumbens ◽

Receptor Agonist ◽

Gabab Receptor ◽

Aminobutyric Acid ◽

Dopamine Level ◽

Gamma Aminobutyric Acid ◽

Type B ◽

Acid Type ◽

Rat Nucleus Accumbens

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The efficacy of γ-aminobutyric acid type A receptor (GABA AR) subtype-selective positive allosteric modulators in blocking tetramethylenedisulfotetramine (TETS)-induced seizure-like behavior in larval zebrafish with minimal sedation

Toxicology and Applied Pharmacology ◽

10.1016/j.taap.2021.115643 ◽

2021 ◽

pp. 115643

Author(s):

Paige C. Mundy ◽

Brandon Pressly ◽

Dennis R. Carty ◽

Bianca Yaghoobi ◽

Heike Wulff ◽

...

Keyword(s):

Type A ◽

Aminobutyric Acid ◽

Allosteric Modulators ◽

Larval Zebrafish ◽

Acid Type ◽

Positive Allosteric Modulators ◽

Subtype Selective

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Targeting the γ-Aminobutyric Acid Type B (GABAB) Receptor Complex: Development of Inhibitors Targeting the K+ Channel Tetramerization Domain (KCTD) Containing Proteins/GABAB Receptor Protein–Protein Interaction

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.9b01087 ◽

2019 ◽

Vol 62 (19) ◽

pp. 8819-8830 ◽

Cited By ~ 4

Author(s):

Vita Sereikaite ◽

Thorsten Fritzius ◽

Vikram B. Kasaragod ◽

Nicole Bader ◽

Hans M. Maric ◽

...

Keyword(s):

Gabab Receptor ◽

Aminobutyric Acid ◽

Receptor Protein ◽

K Channel ◽

Receptor Complex ◽

Type B ◽

Protein Protein Interaction ◽

Tetramerization Domain ◽

Acid Type ◽

Complex Development

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γ-Aminobutyric Acid Type B (GABAB) Receptor Expression Is Needed for Inhibition of N-type (Cav2.2) Calcium Channels by Analgesic α-Conotoxins

Journal of Biological Chemistry ◽

10.1074/jbc.m112.342998 ◽

2012 ◽

Vol 287 (28) ◽

pp. 23948-23957 ◽

Cited By ~ 37

Author(s):

Hartmut Cuny ◽

Andrew de Faoite ◽

Thuan G. Huynh ◽

Takahiro Yasuda ◽

Géza Berecki ◽

...

Keyword(s):

Calcium Channels ◽

Gabab Receptor ◽

Receptor Expression ◽

Aminobutyric Acid ◽

Type B ◽

Acid Type

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3β-Methyl-Neurosteroid Analogs Are Preferential Positive Allosteric Modulators and Direct Activators of Extrasynaptic δ-Subunit γ-Aminobutyric Acid Type A Receptors in the Hippocampus Dentate Gyrus Subfield

Journal of Pharmacology and Experimental Therapeutics ◽

10.1124/jpet.117.246660 ◽

2018 ◽

Vol 365 (3) ◽

pp. 583-601 ◽

Cited By ~ 8

Author(s):

Shu-Hui Chuang ◽

Doodipala Samba Reddy

Keyword(s):

Dentate Gyrus ◽

Type A ◽

Aminobutyric Acid ◽

Allosteric Modulators ◽

Acid Type ◽

Positive Allosteric Modulators

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The gamma-aminobutyric acid type A receptor positive allosteric modulators brexanolone injection and SAGE-217 in the treatment of mood disorders: Results from recent placebo-controlled studies

10.1055/s-0039-1679163 ◽

2019 ◽

Author(s):

H Junker ◽

S Kanes ◽

S Meltzer-Brody ◽

H Gunduz-Bruce ◽

A Sankoh ◽

...

Keyword(s):

Mood Disorders ◽

Type A ◽

Aminobutyric Acid ◽

Allosteric Modulators ◽

Gamma Aminobutyric Acid ◽

Acid Type ◽

Positive Allosteric Modulators

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-Aminobutyric Acid Type B (GABAB) Receptor Internalization Is Regulated by the R2 Subunit

Journal of Biological Chemistry ◽

10.1074/jbc.m110.220814 ◽

2011 ◽

Vol 286 (27) ◽

pp. 24324-24335 ◽

Cited By ~ 7

Author(s):

S. Hannan ◽

M. E. Wilkins ◽

E. Dehghani-Tafti ◽

P. Thomas ◽

S. M. Baddeley ◽

...

Keyword(s):

Gabab Receptor ◽

Receptor Internalization ◽

Aminobutyric Acid ◽

Type B ◽

Acid Type ◽

R2 Subunit

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