Aza-acyclic Nucleoside Phosphonates Containing a Second Phosphonate Group As Inhibitors of the Human, Plasmodium falciparum and vivax 6-Oxopurine Phosphoribosyltransferases and Their Prodrugs As Antimalarial Agents

2014 ◽  
Vol 58 (2) ◽  
pp. 827-846 ◽  
Author(s):  
Dianne T. Keough ◽  
Dana Hocková ◽  
Zlatko Janeba ◽  
Tzu-Hsuan Wang ◽  
Lieve Naesens ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Phosphonate Group ◽  
Antimalarial Agents ◽  
Acyclic Nucleoside Phosphonates ◽  
Acyclic Nucleoside ◽  
Human Plasmodium

Inhibition of the in vitro growth of Plasmodium falciparum by acyclic nucleoside phosphonates

1999 ◽  
Vol 12 (1) ◽  
pp. 53-61 ◽  
Author(s):  
L.J.J.W. Smeijsters ◽  
F.F.J. Franssen ◽  
L. Naesens ◽  
E. de Vries ◽  
A. Holý ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
In Vitro Growth ◽  
Acyclic Nucleoside Phosphonates ◽  
Acyclic Nucleoside

Acyclic Nucleoside Phosphonates Containing a Second Phosphonate Group Are Potent Inhibitors of 6-Oxopurine Phosphoribosyltransferases and Have Antimalarial Activity

2013 ◽  
Vol 56 (6) ◽  
pp. 2513-2526 ◽  
Author(s):  
Dianne T. Keough ◽  
Petr Špaček ◽  
Dana Hocková ◽  
Tomáš Tichý ◽  
Silvie Vrbková ◽  
...  
Keyword(s):  
Antimalarial Activity ◽  
Phosphonate Group ◽  
Acyclic Nucleoside Phosphonates ◽  
Acyclic Nucleoside

Acyclic nucleoside phosphonates and human telomerase inhibition

2005 ◽  
Author(s):  
Miroslav Hájek ◽  
Naděžda Matulová ◽  
Ivan Votruba ◽  
Antonín Holý ◽  
Eva Tloušťová
Keyword(s):  
Telomerase Inhibition ◽  
Acyclic Nucleoside Phosphonates ◽  
Acyclic Nucleoside ◽  
Human Telomerase

Tyrosine-based prodrugs of acyclic nucleoside phosphonates

2014 ◽  
Author(s):  
Tomáš Tichý ◽  
Karel Pomeisl ◽  
Marcela Krečmerová ◽  
Charles E. McKenna
Keyword(s):  
Acyclic Nucleoside Phosphonates ◽  
Acyclic Nucleoside
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