Methyl Effect in Azumamides Provides Insight Into Histone Deacetylase Inhibition by Macrocycles

2014 ◽  
Vol 57 (22) ◽  
pp. 9644-9657 ◽  
Author(s):  
Alex R. Maolanon ◽  
Jesper S. Villadsen ◽  
Niels J. Christensen ◽  
Casper Hoeck ◽  
Tina Friis ◽  
...  
Keyword(s):  
Histone Deacetylase ◽  
Histone Deacetylase Inhibition ◽  
Methyl Effect ◽  
Insight Into

scholarly journals Synergistic anti-cancer effect of histone deacetylase inhibition and blockade of the glycolytic pathway

2018 ◽  
Vol 29 ◽  
pp. viii646
Author(s):  
S.Y. Kim ◽  
Y.S. Lee ◽  
H. Chang ◽  
H.-S. Chang ◽  
C.S. Park
Keyword(s):  
Histone Deacetylase ◽  
Glycolytic Pathway ◽  
Histone Deacetylase Inhibition ◽  
Anti Cancer

scholarly journals Genome-Wide STAT3 Binding Analysis after Histone Deacetylase Inhibition Reveals Novel Target Genes in Dendritic Cells

2016 ◽  
Vol 9 (2) ◽  
pp. 126-144 ◽  
Author(s):  
Yaping Sun ◽  
Matthew Iyer ◽  
Richard McEachin ◽  
Meng Zhao ◽  
Yi-Mi Wu ◽  
...  
Keyword(s):  
Gene Expression ◽  
Dendritic Cells ◽  
Histone Deacetylase ◽  
Antigen Processing ◽  
Target Genes ◽  
Hdac Inhibition ◽  
Histone Deacetylase Inhibition ◽  
Immune Effector ◽  
Chip Sequencing ◽  
Genome Wide

STAT3 is a master transcriptional regulator that plays an important role in the induction of both immune activation and immune tolerance in dendritic cells (DCs). The transcriptional targets of STAT3 in promoting DC activation are becoming increasingly understood; however, the mechanisms underpinning its role in causing DC suppression remain largely unknown. To determine the functional gene targets of STAT3, we compared the genome-wide binding of STAT3 using ChIP sequencing coupled with gene expression microarrays to determine STAT3-dependent gene regulation in DCs after histone deacetylase (HDAC) inhibition. HDAC inhibition boosted the ability of STAT3 to bind to distinct DNA targets and regulate gene expression. Among the top 500 STAT3 binding sites, the frequency of canonical motifs was significantly higher than that of noncanonical motifs. Functional analysis revealed that after treatment with an HDAC inhibitor, the upregulated STAT3 target genes were those that were primarily the negative regulators of proinflammatory cytokines and those in the IL-10 signaling pathway. The downregulated STAT3-dependent targets were those involved in immune effector processes and antigen processing/presentation. The expression and functional relevance of these genes were validated. Specifically, functional studies confirmed that the upregulation of IL-10Ra by STAT3 contributed to the suppressive function of DCs following HDAC inhibition.

scholarly journals Histone deacetylase inhibition induces odor preference memory extension and maintains enhanced AMPA receptor expression in the rat pup model

2017 ◽  
Vol 24 (10) ◽  
pp. 543-551 ◽  
Author(s):  
Sriya Bhattacharya ◽  
Bandhan Mukherjee ◽  
Jules J.E. Doré ◽  
Qi Yuan ◽  
Carolyn W. Harley ◽  
...  
Keyword(s):  
Histone Deacetylase ◽  
Ampa Receptor ◽  
Receptor Expression ◽  
Odor Preference ◽  
Histone Deacetylase Inhibition ◽  
Rat Pup

Histone deacetylase inhibition abolishes stress-induced spatial memory impairment

2016 ◽  
Vol 134 ◽  
pp. 328-338 ◽  
Author(s):  
Viviana Vargas-López ◽  
Marisol R. Lamprea ◽  
Alejandro Múnera
Keyword(s):  
Spatial Memory ◽  
Histone Deacetylase ◽  
Memory Impairment ◽  
Histone Deacetylase Inhibition

Abstract P118: Analysis of macrophage function and histone deacetylase inhibition in neuroblastoma

2021 ◽  
Author(s):  
Gabrielle L. Brumfield ◽  
Shelby M. Knoche ◽  
Alaina C. Larson ◽  
Brittany J. Poelaert ◽  
Benjamin T. Goetz ◽  
...  
Keyword(s):  
Histone Deacetylase ◽  
Histone Deacetylase Inhibition ◽  
Macrophage Function

Sp1 elements inSULT2B1bpromoter and 5′-untranslated region of mRNA: Sp1/Sp2 induction and augmentation by histone deacetylase inhibition

FEBS Letters ◽  
2005 ◽  
Vol 579 (17) ◽  
pp. 3639-3645 ◽  
Author(s):  
Young C. Lee ◽  
Yuko Higashi ◽  
Chu Luu ◽  
Chikara Shimizu ◽  
Charles A. Strott
Keyword(s):  
Histone Deacetylase ◽  
Untranslated Region ◽  
Histone Deacetylase Inhibition

scholarly journals Class I histone deacetylase inhibition improves pancreatitis outcome by limiting leukocyte recruitment and acinar-to-ductal metaplasia

2017 ◽  
Vol 174 (21) ◽  
pp. 3865-3880 ◽  
Author(s):  
Marta Bombardo ◽  
Enrica Saponara ◽  
Ermanno Malagola ◽  
Rong Chen ◽  
Gitta M Seleznik ◽  
...  
Keyword(s):  
Histone Deacetylase ◽  
Leukocyte Recruitment ◽  
Class I ◽  
Histone Deacetylase Inhibition ◽  
Acinar To Ductal Metaplasia

scholarly journals Radiosensitization In Vivo by Histone Deacetylase Inhibition with No Increase in Early Normal Tissue Radiation Toxicity

2017 ◽  
Vol 17 (2) ◽  
pp. 381-392 ◽  
Author(s):  
Blaz Groselj ◽  
Jia-Ling Ruan ◽  
Helen Scott ◽  
Jessica Gorrill ◽  
Judith Nicholson ◽  
...  
Keyword(s):  
Histone Deacetylase ◽  
Normal Tissue ◽  
Radiation Toxicity ◽  
Histone Deacetylase Inhibition
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