Discovery and Optimization of 4,5-Diarylisoxazoles as Potent Dual Inhibitors of Pyruvate Dehydrogenase Kinase and Heat Shock Protein 90

2014 ◽  
Vol 57 (23) ◽  
pp. 9832-9843 ◽  
Author(s):  
Tao Meng ◽  
Dadong Zhang ◽  
Zuoquan Xie ◽  
Ting Yu ◽  
Shuchao Wu ◽  
...  
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Pyruvate Dehydrogenase ◽  
Heat Shock Protein 90 ◽  
Pyruvate Dehydrogenase Kinase ◽  
Dual Inhibitors

Dual Targeting Strategies On Histone Deacetylase 6 (HDAC6) And Heat Shock Protein 90 (Hsp90)

2021 ◽  
Vol 28 ◽  
Author(s):  
Davide Bonanni ◽  
Andrea Citarella ◽  
Davide Moi ◽  
Luca Pinzi ◽  
Elisa Bergamini ◽  
...  
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Histone Deacetylase ◽  
Single Molecule ◽  
Heat Shock Protein 90 ◽  
Histone Deacetylase 6 ◽  
Small Molecular Weight ◽  
Antitumor Effects ◽  
Target Drug ◽  
Dual Inhibitors

: The design of multi-target drugs acting simultaneously on multiple signaling pathways is a growing field in medicinal chemistry, especially for the treatment of complex diseases such as cancer. Histone deacetylase 6 (HDAC6) is an established anticancer drug target involved in tumor cells transformation. Being an epigenetic enzyme at the interplay of many biological processes, HDAC6 has become an attractive target for polypharmacology studies aimed at improving therapeutic efficacy of anticancer drugs. For example, the molecular chaperone Heat shock protein 90 (Hsp90) is a substrate of HDAC6 deacetylation, and several lines of evidence demonstrate that simultaneous inhibition of HDAC6 and Hsp90 promote synergistic antitumor effects on different cancer cell lines, highlighting the potential benefits of developing a single molecule endowed with multi-target activity. This review will summarize the complex interplay between HDAC6 and Hsp90, providing also useful hints for multi-target drug design and discovery approaches in this field. To this end, crystallographic structures of HDAC6 and Hsp90 complexes will be extensively reviewed in the light of discussing binding pockets features and pharmacophore requirements and providing useful guidelines for the design of dual inhibitors. The few examples of multi-target inhibitors obtained so far, mostly based on chimeric approaches, will be summarized and put into context. Finally, the main features of HDAC6 and Hsp90 inhibitors will be compared, and ligand- and structure-based strategies potentially useful for the development of small molecular weight dual inhibitors will be proposed and discussed.

scholarly journals Design of Dual Inhibitors of Histone Deacetylase 6 and Heat Shock Protein 90

ACS Omega ◽  
2020 ◽  
Vol 5 (20) ◽  
pp. 11473-11480 ◽  
Author(s):  
Luca Pinzi ◽  
Rosaria Benedetti ◽  
Lucia Altucci ◽  
Giulio Rastelli
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Histone Deacetylase ◽  
Heat Shock Protein 90 ◽  
Histone Deacetylase 6 ◽  
Dual Inhibitors

scholarly journals Heat shock protein 90 and serine/threonine kinase B-Raf inhibitors have overlapping chemical space

RSC Advances ◽  
2017 ◽  
Vol 7 (49) ◽  
pp. 31069-31074 ◽  
Author(s):  
A. Anighoro ◽  
L. Pinzi ◽  
G. Marverti ◽  
J. Bajorath ◽  
G. Rastelli
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Chemical Space ◽  
Heat Shock Protein 90 ◽  
Computational Design ◽  
Serine Threonine Kinase ◽  
Threonine Kinase ◽  
Dual Inhibitors

With the aid of computational design, we show that Hsp90 and B-Raf inhibitors have overlapping chemical space and we disclose the first-in-class dual inhibitors.

Glycyrrhizin effects rat hepatocytes via the reduction of heat shock protein 90 expression

2001 ◽  
Vol 120 (5) ◽  
pp. A357-A357
Author(s):  
T YOH ◽  
T NAKASHIMA ◽  
Y SUMIDA ◽  
Y KAKISAKA ◽  
H ISHIKAWA ◽  
...  
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Heat Shock Protein 90 ◽  
Rat Hepatocytes
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