scholarly journals Design, Synthesis, and Evaluation of Nonretinoid Retinol Binding Protein 4 Antagonists for the Potential Treatment of Atrophic Age-Related Macular Degeneration and Stargardt Disease

2014 ◽  
Vol 57 (18) ◽  
pp. 7731-7757 ◽  
Author(s):  
Christopher L. Cioffi ◽  
Nicoleta Dobri ◽  
Emily E. Freeman ◽  
Michael P. Conlon ◽  
Ping Chen ◽  
...  
Keyword(s):  
Macular Degeneration ◽  
Binding Protein ◽  
Age Related Macular Degeneration ◽  
Retinol Binding Protein ◽  
Potential Treatment ◽  
Stargardt Disease ◽  
Design Synthesis ◽  
Retinol Binding Protein 4 ◽  
Age Related

scholarly journals Computational Quantification of Complex Fundus Phenotypes in Age-Related Macular Degeneration and Stargardt Disease

2011 ◽  
Vol 52 (6) ◽  
pp. 2976 ◽  
Author(s):  
Gwenole Quellec ◽  
Stephen R. Russell ◽  
Todd E. Scheetz ◽  
Edwin M. Stone ◽  
Michael D. Abràmoff
Keyword(s):  
Macular Degeneration ◽  
Age Related Macular Degeneration ◽  
Stargardt Disease ◽  
Age Related

scholarly journals Healthcare Cost of Stargardt Disease

2020 ◽  
Author(s):  
Kanza Aziz ◽  
Bonnielin K. Swenor ◽  
Joseph K. Canner ◽  
Mandeep S. Singh
Keyword(s):  
Macular Degeneration ◽  
Healthcare Cost ◽  
Financial Burden ◽  
Age Related Macular Degeneration ◽  
Administrative Claims ◽  
Direct Healthcare Cost ◽  
Stargardt Disease ◽  
Cross Sectional ◽  
Patient Cost ◽  
Age Related

AbstractImportanceStargardt disease (SD) is the most common juvenile macular degeneration and a leading cause of uncorrectable childhood blindness. The progressive and incurable nature of this chronic condition entails a long-term financial burden on affected individuals. The economic costs of SD have not been characterized in detail.ObjectiveTo estimate the direct healthcare cost of SD.DesignCross-sectional analysis of healthcare claims.ParticipantsPatients with an ICD-9 diagnosis code of SD, non-exudative age-related macular degeneration (AMD), or bilateral sensorineural hearing loss (SHL).MethodsOutpatient administrative claims data from the IBM® MarketScan® Commercial Claims and Encounters Database from 2010 to 2014 were analyzed.Main Outcome MeasureAnnual per-patient direct healthcare cost.ResultsA total of 472,428 patients were analyzed (5,015 SD, 369,750 SHL and 97,663 AMD patients respectively). The payment per year of insurance coverage for SD (median: $105.58, IQR: $50.53-$218.71) was higher than that of SHL (median: $51.01, IQR: $25.66-$121.66, p <0.001) and AMD (median: $76.20, IQR: $38.00-$164.86, p <0.001). When adjusted for covariates, the annual payment for SD was $47.83 higher than SHL (p<0.001) and $17.34 higher than AMD (p<0.001).Conclusions and RelevanceThere is a significant direct healthcare cost associated with SD. The annual per-patient cost of SD was higher than SHL, another condition that causes sensory impairment in people of all ages, and nonexudative AMD which causes a similar pattern of visual loss that typically begins later in life. The total lifetime per-patient cost of SD may exceed that of nonexudative AMD.

scholarly journals Design, Synthesis, and Preclinical Efficacy of Novel Nonretinoid Antagonists of Retinol-Binding Protein 4 in the Mouse Model of Hepatic Steatosis

2019 ◽  
Vol 62 (11) ◽  
pp. 5470-5500 ◽  
Author(s):  
Christopher L. Cioffi ◽  
Boglarka Racz ◽  
Andras Varadi ◽  
Emily E. Freeman ◽  
Michael P. Conlon ◽  
...  
Keyword(s):  
Mouse Model ◽  
Hepatic Steatosis ◽  
Binding Protein ◽  
Retinol Binding Protein ◽  
Design Synthesis ◽  
Retinol Binding Protein 4 ◽  
Preclinical Efficacy

scholarly journals A Comprehensive Survey of Sequence Variation in the ABCA4 (ABCR) Gene in Stargardt Disease and Age-Related Macular Degeneration

2000 ◽  
Vol 67 (4) ◽  
pp. 800-813 ◽  
Author(s):  
Andrea Rivera ◽  
Karen White ◽  
Heidi Stöhr ◽  
Klaus Steiner ◽  
Nadine Hemmrich ◽  
...  
Keyword(s):  
Macular Degeneration ◽  
Sequence Variation ◽  
Age Related Macular Degeneration ◽  
Stargardt Disease ◽  
Age Related ◽  
Comprehensive Survey

Mutation Analysis of Oxisterol-Binding-Protein Gene in Patients with Age-Related Macular Degeneration

2007 ◽  
Vol 11 (4) ◽  
pp. 421-426 ◽  
Author(s):  
Margherita Torrini ◽  
Cristiana Marchese ◽  
Mario Vanzetti ◽  
Valeria Marini ◽  
Paola Origone ◽  
...  
Keyword(s):  
Macular Degeneration ◽  
Mutation Analysis ◽  
Protein Gene ◽  
Binding Protein ◽  
Age Related Macular Degeneration ◽  
Age Related ◽  
Binding Protein Gene
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