Synthesis of P1′-Functionalized Macrocyclic Transition-State Mimicking HIV-1 Protease Inhibitors Encompassing a Tertiary Alcohol

2014 ◽  
Vol 57 (15) ◽  
pp. 6444-6457 ◽  
Author(s):  
Maria De Rosa ◽  
Johan Unge ◽  
Hitesh V. Motwani ◽  
Åsa Rosenquist ◽  
Lotta Vrang ◽  
...  
Keyword(s):  
Transition State ◽  
Protease Inhibitors ◽  
Tertiary Alcohol ◽  
Hiv 1

HIV-1 Protease Inhibitors with a Transition-State Mimic Comprising a Tertiary Alcohol: Improved Antiviral Activity in Cells

2010 ◽  
Vol 53 (2) ◽  
pp. 607-615 ◽  
Author(s):  
A.K. Mahalingam ◽  
Linda Axelsson ◽  
Jenny K. Ekegren ◽  
Johan Wannberg ◽  
Jacob Kihlström ◽  
...  
Keyword(s):  
Antiviral Activity ◽  
Transition State ◽  
Protease Inhibitors ◽  
Tertiary Alcohol ◽  
Hiv 1 ◽  
In Cells

scholarly journals Two-Carbon-Elongated HIV-1 Protease Inhibitors with a Tertiary-Alcohol-Containing Transition-State Mimic

2008 ◽  
Vol 51 (8) ◽  
pp. 2586-2586 ◽  
Author(s):  
Xiongyu Wu ◽  
Per Öhrngren ◽  
Jenny K. Ekegren ◽  
Johan Unge ◽  
Torsten Unge ◽  
...  
Keyword(s):  
Transition State ◽  
Protease Inhibitors ◽  
Tertiary Alcohol ◽  
Hiv 1

A New Class of HIV-1 Protease Inhibitors Containing a Tertiary Alcohol in the Transition-State Mimicking Scaffold

2005 ◽  
Vol 48 (25) ◽  
pp. 8098-8102 ◽  
Author(s):  
Jenny K. Ekegren ◽  
Torsten Unge ◽  
Mayada Zreik Safa ◽  
Hans Wallberg ◽  
Bertil Samuelsson ◽  
...  
Keyword(s):  
Transition State ◽  
Protease Inhibitors ◽  
Tertiary Alcohol ◽  
New Class ◽  
Hiv 1

HIV-1 protease inhibitors with a tertiary alcohol containing transition-state mimic and various P2 and P1′ substituents

MedChemComm ◽  
2011 ◽  
Vol 2 (8) ◽  
pp. 701 ◽  
Author(s):  
Per Öhrngren ◽  
Xiongyu Wu ◽  
Magnus Persson ◽  
Jenny K. Ekegren ◽  
Hans Wallberg ◽  
...  
Keyword(s):  
Transition State ◽  
Protease Inhibitors ◽  
Tertiary Alcohol ◽  
Hiv 1

Microwave-Accelerated Synthesis of P1‘-Extended HIV-1 Protease Inhibitors Encompassing a Tertiary Alcohol in the Transition-State Mimicking Scaffold

2006 ◽  
Vol 49 (5) ◽  
pp. 1828-1832 ◽  
Author(s):  
Jenny K. Ekegren ◽  
Nina Ginman ◽  
Åsa Johansson ◽  
Hans Wallberg ◽  
Mats Larhed ◽  
...  
Keyword(s):  
Transition State ◽  
Protease Inhibitors ◽  
Tertiary Alcohol ◽  
Hiv 1

Two-Carbon-Elongated HIV-1 Protease Inhibitors with a Tertiary-Alcohol-Containing Transition-State Mimic⊥

2008 ◽  
Vol 51 (4) ◽  
pp. 1053-1057 ◽  
Author(s):  
Xiongyu Wu ◽  
Per Öhrngren ◽  
Jenny K. Ekegren ◽  
Johan Unge ◽  
Torsten Unge ◽  
...  
Keyword(s):  
Transition State ◽  
Protease Inhibitors ◽  
Tertiary Alcohol ◽  
Hiv 1

Variations of the P2 group in HIV-1 protease inhibitors containing a tertiary alcohol in the transition-state mimicking scaffold

2006 ◽  
Vol 4 (16) ◽  
pp. 3040 ◽  
Author(s):  
Jenny K. Ekegren ◽  
Johan Gising ◽  
Hans Wallberg ◽  
Mats Larhed ◽  
Bertil Samuelsson ◽  
...  
Keyword(s):  
Transition State ◽  
Protease Inhibitors ◽  
Tertiary Alcohol ◽  
Hiv 1

A series of potent HIV-1 protease inhibitors containing a hydroxyethyl secondary amine transition state isostere: synthesis, enzyme inhibition, and antiviral activity

1992 ◽  
Vol 35 (14) ◽  
pp. 2525-2533 ◽  
Author(s):  
Thomas J. Tucker ◽  
William C. Lumma ◽  
Linda S. Payne ◽  
Jenny M. Wai ◽  
S. Jane De Solms ◽  
...  
Keyword(s):  
Antiviral Activity ◽  
Transition State ◽  
Protease Inhibitors ◽  
Enzyme Inhibition ◽  
Secondary Amine ◽  
Hiv 1

ChemInform Abstract: Aspartic Protease Inhibitors Containing Tertiary Alcohol Transition-State Mimics

ChemInform ◽  
2015 ◽  
Vol 46 (8) ◽  
pp. no-no
Author(s):  
Hitesh V. Motwani ◽  
Maria De Rosa ◽  
Luke R. Odell ◽  
Anders Hallberg ◽  
Mats Larhed
Keyword(s):  
Transition State ◽  
Protease Inhibitors ◽  
Tertiary Alcohol ◽  
Aspartic Protease
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