scholarly journals Optimization of Small-Molecule Inhibitors of Influenza Virus Polymerase: From Thiophene-3-Carboxamide to Polyamido Scaffolds

2014 ◽  
Vol 57 (10) ◽  
pp. 4337-4350 ◽  
Author(s):  
Susan Lepri ◽  
Giulio Nannetti ◽  
Giulia Muratore ◽  
Gabriele Cruciani ◽  
Renzo Ruzziconi ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Small Molecule ◽  
Small Molecule Inhibitors

scholarly journals Small Molecule Inhibitors of Influenza Virus Entry

2021 ◽  
Vol 14 (6) ◽  
pp. 587
Author(s):  
Zhaoyu Chen ◽  
Qinghua Cui ◽  
Michael Caffrey ◽  
Lijun Rong ◽  
Ruikun Du
Keyword(s):  
Influenza Virus ◽  
Membrane Fusion ◽  
Small Molecule ◽  
Drug Target ◽  
Small Molecule Inhibitors ◽  
Virus Entry ◽  
Critical Role ◽  
Structural Basis ◽  
Future Directions ◽  
The Past

Hemagglutinin (HA) plays a critical role during influenza virus receptor binding and subsequent membrane fusion process, thus HA has become a promising drug target. For the past several decades, we and other researchers have discovered a series of HA inhibitors mainly targeting its fusion machinery. In this review, we summarize the advances in HA-targeted development of small molecule inhibitors. Moreover, we discuss the structural basis and mode of action of these inhibitors, and speculate upon future directions toward more potent inhibitors of membrane fusion and potential anti-influenza drugs.

scholarly journals Design, synthesis, and evaluation of novel small molecule inhibitors of the influenza virus protein NS1

2012 ◽  
Vol 20 (1) ◽  
pp. 487-497 ◽  
Author(s):  
Joseph J. Jablonski ◽  
Dipwanita Basu ◽  
Daniel A. Engel ◽  
H. Mario Geysen
Keyword(s):  
Influenza Virus ◽  
Small Molecule ◽  
Small Molecule Inhibitors ◽  
Virus Protein ◽  
Design Synthesis
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