Design, Synthesis, and Biological Evaluation of DeuteratedC-Aryl Glycoside as a Potent and Long-Acting Renal Sodium-Dependent Glucose Cotransporter 2 Inhibitor for the Treatment of Type 2 Diabetes

Ge Xu; Binhua Lv; Jacques Y. Roberge; Baihua Xu; Jiyan Du; Jiajia Dong; Yuanwei Chen; Kun Peng; Lili Zhang; Xinxing Tang; Yan Feng; Min Xu; Wei Fu; Wenbin Zhang; Liangcheng Zhu; Zhongping Deng; Zelin Sheng; Ajith Welihinda; Xun Sun

doi:10.1021/jm401780b

Design, Synthesis, and Biological Evaluation of DeuteratedC-Aryl Glycoside as a Potent and Long-Acting Renal Sodium-Dependent Glucose Cotransporter 2 Inhibitor for the Treatment of Type 2 Diabetes

Journal of Medicinal Chemistry ◽

10.1021/jm401780b ◽

2014 ◽

Vol 57 (4) ◽

pp. 1236-1251 ◽

Cited By ~ 39

Author(s):

Ge Xu ◽

Binhua Lv ◽

Jacques Y. Roberge ◽

Baihua Xu ◽

Jiyan Du ◽

...

Keyword(s):

Type 2 Diabetes ◽

Biological Evaluation ◽

Design Synthesis ◽

Sodium Dependent ◽

Long Acting ◽

Synthesis And Biological Evaluation ◽

Aryl Glycoside

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Design, synthesis and biological evaluation of 6-deoxy O-spiroketal C-arylglucosides as novel renal sodium-dependent glucose cotransporter 2 (SGLT2) inhibitors for the treatment of type 2 diabetes

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2019.07.032 ◽

2019 ◽

Vol 180 ◽

pp. 398-416 ◽

Cited By ~ 3

Author(s):

Yibing Wang ◽

Yang Lou ◽

Jiang Wang ◽

Dan Li ◽

Hui Chen ◽

...

Keyword(s):

Type 2 Diabetes ◽

Biological Evaluation ◽

Sglt2 Inhibitors ◽

Design Synthesis ◽

Sodium Dependent ◽

Synthesis And Biological Evaluation

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Design, synthesis and biological evaluation of 4,7,12,12a-tetrahydro-5 H -thieno[3′,2’:3,4]pyrido[1,2- b ]isoquinolines as novel adenosine 5′-monophosphate-activated protein kinase (AMPK) indirect activators for the treatment of type 2 diabetes

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2017.09.012 ◽

2017 ◽

Vol 140 ◽

pp. 448-464 ◽

Cited By ~ 8

Author(s):

Shengbin Zhou ◽

Yanan Duan ◽

Jiang Wang ◽

Jin Zhang ◽

Haifeng Sun ◽

...

Keyword(s):

Type 2 Diabetes ◽

Protein Kinase ◽

Biological Evaluation ◽

Design Synthesis ◽

Synthesis And Biological Evaluation

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Design, synthesis and biological evaluation of vincamine derivatives as potential pancreatic β-cells protective agents for the treatment of type 2 diabetes mellitus

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2019.111976 ◽

2020 ◽

Vol 188 ◽

pp. 111976 ◽

Cited By ~ 1

Author(s):

Junwei Wang ◽

Xue Lv ◽

Jiawen Xu ◽

Xinpeng Liu ◽

Te Du ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Biological Evaluation ◽

Β Cells ◽

Pancreatic Β Cells ◽

Design Synthesis ◽

Protective Agents ◽

Synthesis And Biological Evaluation

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Design, synthesis and biological evaluation of GY3-based derivatives for anti-type 2 diabetes activity

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2015.02.021 ◽

2015 ◽

Vol 25 (7) ◽

pp. 1500-1505 ◽

Cited By ~ 1

Author(s):

Lingling Fan ◽

Jianta Wang ◽

Xiao Ma ◽

Wan Xiao ◽

Zhiyan Li ◽

...

Keyword(s):

Type 2 Diabetes ◽

Biological Evaluation ◽

Design Synthesis ◽

Synthesis And Biological Evaluation

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Synthesis and biological evaluation of pyrrolidine-2-carbonitrile and 4-fluoropyrrolidine-2-carbonitrile derivatives as dipeptidyl peptidase-4 inhibitors for the treatment of type 2 diabetes

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2013.09.048 ◽

2013 ◽

Vol 21 (23) ◽

pp. 7418-7429 ◽

Cited By ~ 14

Author(s):

Jiang Wang ◽

Ying Feng ◽

Xun Ji ◽

Guanghui Deng ◽

Ying Leng ◽

...

Keyword(s):

Type 2 Diabetes ◽

Dipeptidyl Peptidase ◽

Biological Evaluation ◽

Dipeptidyl Peptidase 4 ◽

Dipeptidyl Peptidase 4 Inhibitors ◽

Synthesis And Biological Evaluation

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Synthesis and biological evaluation of C-glucosides with azulene rings as selective SGLT2 inhibitors for the treatment of type 2 diabetes mellitus: Discovery of YM543

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2013.03.067 ◽

2013 ◽

Vol 21 (13) ◽

pp. 3934-3948 ◽

Cited By ~ 26

Author(s):

Kazuhiro Ikegai ◽

Masakazu Imamura ◽

Takayuki Suzuki ◽

Keita Nakanishi ◽

Takeshi Murakami ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Biological Evaluation ◽

Sglt2 Inhibitors ◽

Synthesis And Biological Evaluation

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Synthesis and biological evaluation of azobicyclo[3.3.0] octane derivatives as dipeptidyl peptidase 4 inhibitors for the treatment of type 2 diabetes

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2010.04.120 ◽

2010 ◽

Vol 20 (12) ◽

pp. 3565-3568 ◽

Cited By ~ 6

Author(s):

Tang Peng Cho ◽

Yang Fang Long ◽

Lin Zhi Gang ◽

Wang Yang ◽

Lu He Jun ◽

...

Keyword(s):

Type 2 Diabetes ◽

Dipeptidyl Peptidase ◽

Biological Evaluation ◽

Dipeptidyl Peptidase 4 ◽

Dipeptidyl Peptidase 4 Inhibitors ◽

Synthesis And Biological Evaluation

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Design, synthesis and biological evaluation of PEGylated Xenopus glucagon-like peptide-1 derivatives as long-acting hypoglycemic agents

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2017.03.032 ◽

2017 ◽

Vol 132 ◽

pp. 81-89 ◽

Cited By ~ 21

Author(s):

Jing Han ◽

Yiyun Wang ◽

Qinghua Meng ◽

Guangchao Li ◽

Fangmin Huang ◽

...

Keyword(s):

Biological Evaluation ◽

Hypoglycemic Agents ◽

Design Synthesis ◽

Glucagon Like Peptide ◽

Glucagon Like Peptide 1 ◽

Long Acting ◽

Synthesis And Biological Evaluation

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Design, synthesis, biological evaluation and molecular dynamics simulation studies of (R)-5-methylthiazolidin-4-One derivatives as megakaryocyte protein tyrosine phosphatase 2 (PTP-MEG2) inhibitors for the treatment of type 2 diabetes

Journal of Biomolecular Structure and Dynamics ◽

10.1080/07391102.2019.1654410 ◽

2019 ◽

Vol 38 (11) ◽

pp. 3156-3165 ◽

Cited By ~ 3

Author(s):

Jingwei Wu ◽

Yingzhan Sun ◽

Hui Zhou ◽

Ying Ma ◽

Runling Wang

Keyword(s):

Type 2 Diabetes ◽

Molecular Dynamics ◽

Molecular Dynamics Simulation ◽

Protein Tyrosine Phosphatase ◽

Tyrosine Phosphatase ◽

Biological Evaluation ◽

Dynamics Simulation ◽

Simulation Studies ◽

Design Synthesis

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Development of potential preclinical candidates with promising in vitro ADME profile for the inhibition of type 1 and type 2 17β-Hydroxysteroid dehydrogenases: Design, synthesis, and biological evaluation

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2019.05.084 ◽

2019 ◽

Vol 178 ◽

pp. 93-107 ◽

Cited By ~ 1

Author(s):

Ahmed S. Abdelsamie ◽

Mohamed Salah ◽

Lorenz Siebenbürger ◽

Mostafa M. Hamed ◽

Carsten Börger ◽

...

Keyword(s):

Biological Evaluation ◽

Design Synthesis ◽

Hydroxysteroid Dehydrogenases ◽

Adme Profile ◽

Synthesis And Biological Evaluation

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