Stereochemistry of the Tadalafil Diastereoisomers: A Critical Assessment of Vibrational Circular Dichroism, Electronic Circular Dichroism, and Optical Rotatory Dispersion

2013 ◽  
Vol 56 (21) ◽  
pp. 8903-8914 ◽  
Author(s):  
Shi Qiu ◽  
Ewoud De Gussem ◽  
Kourosch Abbaspour Tehrani ◽  
Sergey Sergeyev ◽  
Patrick Bultinck ◽  
...  
Keyword(s):  
Circular Dichroism ◽  
Critical Assessment ◽  
Vibrational Circular Dichroism ◽  
Optical Rotatory Dispersion ◽  
Rotatory Dispersion ◽  
Optical Rotatory ◽  
Electronic Circular Dichroism ◽  
Circular Dichroïsm

A configurational and conformational study of (−)-Oseltamivir using a multi-chiroptical approach

2015 ◽  
Vol 13 (10) ◽  
pp. 2999-3010 ◽  
Author(s):  
Marcin Górecki
Keyword(s):  
Circular Dichroism ◽  
Optical Activity ◽  
Vibrational Circular Dichroism ◽  
Optical Rotatory Dispersion ◽  
Rotatory Dispersion ◽  
Optical Rotatory ◽  
Conformational Study ◽  
Electronic Circular Dichroism ◽  
Raman Optical Activity ◽  
Circular Dichroïsm

Four chiroptical methods, i.e. electronic circular dichroism (ECD), optical rotatory dispersion (ORD), vibrational circular dichroism (VCD), and Raman optical activity (ROA) were employed to discover a set of the most probable conformations of (−)-Oseltamivir in solution.

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