Adenosine A2AReceptor as a Drug Discovery Target

2013 ◽  
Vol 57 (9) ◽  
pp. 3623-3650 ◽  
Author(s):  
Manuel de Lera Ruiz ◽  
Yeon-Hee Lim ◽  
Junying Zheng
Keyword(s):  
Drug Discovery ◽  
Drug Discovery Target

scholarly journals Structural Basis of SARS-CoV-2 3CLpro and Anti-COVID-19 Drug Discovery from Medicinal Plants

2020 ◽  
Author(s):  
Muhammad Tahir ul Qamar ◽  
Safar M. Alqahtani ◽  
Mubarak A. Alamri ◽  
Ling-Ling Chen
Keyword(s):  
Life Cycle ◽  
Drug Discovery ◽  
Medicinal Plants ◽  
Severe Acute Respiratory Syndrome ◽  
Medicinal Plant ◽  
Homology Model ◽  
Structural Basis ◽  
Health Concerns ◽  
Recent Outbreak ◽  
Drug Discovery Target

The recent outbreak of coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 in December 2019 raised global health concerns. The viral 3-chymotrypsin-like cysteine protease (3CLpro) enzyme, which controls coronavirus replication and is essential for its life cycle, is a proven drug discovery target in the case of severe acute respiratory syndrome coronavirus (SARS-CoV) and middle east respiratory syndrome coronavirus (MERS-CoV). Recent studies revealed that the genome sequence of SARS-CoV-2 is very similar to that of SARS-CoV. Therefore, herein, we analysed the 3CLpro sequence, constructed a 3D homology model, and screened it against a medicinal plant library containing 32,297 potential anti-viral phytochemicals/traditional Chinese medicinal compounds. Our analyses revealed that the top nine hits may serve as potential anti- SARS-CoV-2 lead molecules for further optimisation and drug development to control COVID-19.

Keynote review: The adipocyte as a drug discovery target

2005 ◽  
Vol 10 (18) ◽  
pp. 1219-1230 ◽  
Author(s):  
Andrea R. Nawrocki ◽  
Philipp E. Scherer
Keyword(s):  
Drug Discovery ◽  
Drug Discovery Target

Hepatitis C virus NS3 serine protease as a drug discovery target

2003 ◽  
Vol 28 (5) ◽  
pp. 465 ◽  
Author(s):  
F. McPhee ◽  
K.-S. Yeung ◽  
A.C. Good ◽  
N.A. Meanwell
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Drug Discovery ◽  
Serine Protease ◽  
Drug Discovery Target

IL-6 as a drug discovery target

1998 ◽  
Vol 3 (5) ◽  
pp. 202-213 ◽  
Author(s):  
Bernd Stein ◽  
May S Kung Sutherland
Keyword(s):  
Drug Discovery ◽  
Drug Discovery Target

scholarly journals Computational Methods in Road towards Drug Discovery against SARS-CoV2

2020 ◽  
Vol 1 (supplement) ◽  
pp. 6
Author(s):  
Syed Babar Jamal ◽  
Shumaila Naz ◽  
Raees Khan ◽  
Adnan Haider ◽  
Rabail Zehra Raza ◽  
...  
Keyword(s):  
Drug Discovery ◽  
Drug Development ◽  
Computational Methods ◽  
Web Of Science ◽  
Recent Literature ◽  
Future Directions ◽  
The Public ◽  
Pharmaceutical Industries ◽  
Novel Drug ◽  
Drug Discovery Target

SARS-CoV2 has affected millions of people around the globe with hundreds of mortalities. The emergence of SARS-COV2 is very recent, and there is no potential drug or vaccine available. In this review, we have compiled the most frequently used computational methods in drug discovery, target proteins of SARS-CoV2 as well as implementation of computational methods. Most recent literature on SARS-CoV2 has been compiled from various journal search engines including Google Scholar, Academia, PubMed, Scopus, Research Gate, and the Web of Science. The keywords chosen for the searches were COVID-19, Corona Virus, SARS-CoV2, drug development and future directions. This review has far reaching implications to both the public health and pharmaceutical industries for potential novel drug development against SARS-CoV2.

scholarly journals Overview of Mitochondrial E3 Ubiquitin Ligase MITOL/MARCH5 from Molecular Mechanisms to Diseases

2020 ◽  
Vol 21 (11) ◽  
pp. 3781
Author(s):  
Isshin Shiiba ◽  
Keisuke Takeda ◽  
Shun Nagashima ◽  
Shigeru Yanagi
Keyword(s):  
Quality Control ◽  
Drug Discovery ◽  
Ubiquitin Ligase ◽  
Molecular Mechanisms ◽  
Mitochondrial Dynamics ◽  
E3 Ubiquitin Ligase ◽  
Mitochondrial Outer Membrane ◽  
Mitochondrial Quality Control ◽  
Important Regulator ◽  
Drug Discovery Target

The molecular pathology of diseases seen from the mitochondrial axis has become more complex with the progression of research. A variety of factors, including the failure of mitochondrial dynamics and quality control, have made it extremely difficult to narrow down drug discovery targets. We have identified MITOL (mitochondrial ubiquitin ligase: also known as MARCH5) localized on the mitochondrial outer membrane and previously reported that it is an important regulator of mitochondrial dynamics and mitochondrial quality control. In this review, we describe the pathological aspects of MITOL revealed through functional analysis and its potential as a drug discovery target.

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